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Results: 1 to 20 of 142

1.

Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF, Chakrabartty A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19808-13. doi: 10.1073/pnas.1005267107. Epub 2010 Nov 1.

PMID:
21041683
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins.

Sweeting B, Brown E, Khan MQ, Chakrabartty A, Pai EF.

PLoS One. 2013 May 10;8(5):e63047. doi: 10.1371/journal.pone.0063047. Print 2013.

PMID:
23675452
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Differences between the prion protein and its homolog Doppel: a partially structured state with implications for scrapie formation.

Nicholson EM, Mo H, Prusiner SB, Cohen FE, Marqusee S.

J Mol Biol. 2002 Feb 22;316(3):807-15.

PMID:
11866533
[PubMed - indexed for MEDLINE]
4.

Conformational polymorphism of the amyloidogenic peptide homologous to residues 113-127 of the prion protein.

Satheeshkumar KS, Jayakumar R.

Biophys J. 2003 Jul;85(1):473-83.

PMID:
12829502
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Folding and intrinsic stability of deletion variants of PrP(121-231), the folded C-terminal domain of the prion protein.

Eberl H, Glockshuber R.

Biophys Chem. 2002 May 2;96(2-3):293-303.

PMID:
12034448
[PubMed - indexed for MEDLINE]
6.

Expansion of the octarepeat domain alters the misfolding pathway but not the folding pathway of the prion protein.

Leliveld SR, Stitz L, Korth C.

Biochemistry. 2008 Jun 10;47(23):6267-78. doi: 10.1021/bi800253c. Epub 2008 May 13.

PMID:
18473442
[PubMed - indexed for MEDLINE]
7.

The unfolding of the prion protein sheds light on the mechanisms of prion susceptibility and species barrier.

Robinson PJ, Pinheiro TJ.

Biochemistry. 2009 Sep 15;48(36):8551-8. doi: 10.1021/bi901070t.

PMID:
19655812
[PubMed - indexed for MEDLINE]
8.

Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein.

Younan ND, Klewpatinond M, Davies P, Ruban AV, Brown DR, Viles JH.

J Mol Biol. 2011 Jul 15;410(3):369-82. doi: 10.1016/j.jmb.2011.05.013. Epub 2011 May 17.

PMID:
21619885
[PubMed - indexed for MEDLINE]
9.

Disease-associated F198S mutation increases the propensity of the recombinant prion protein for conformational conversion to scrapie-like form.

Vanik DL, Surewicz WK.

J Biol Chem. 2002 Dec 13;277(50):49065-70. Epub 2002 Oct 7.

PMID:
12372829
[PubMed - indexed for MEDLINE]
Free Article
10.

Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).

Cordeiro Y, Lima LM, Gomes MP, Foguel D, Silva JL.

J Biol Chem. 2004 Feb 13;279(7):5346-52. Epub 2003 Nov 21.

PMID:
14634010
[PubMed - indexed for MEDLINE]
Free Article
11.

Molecular model of an alpha-helical prion protein dimer and its monomeric subunits as derived from chemical cross-linking and molecular modeling calculations.

Kaimann T, Metzger S, Kuhlmann K, Brandt B, Birkmann E, Höltje HD, Riesner D.

J Mol Biol. 2008 Feb 15;376(2):582-96. Epub 2007 Nov 21.

PMID:
18158160
[PubMed - indexed for MEDLINE]
12.

Structural factors underlying the species barrier and susceptibility to infection in prion disease.

Sweeting B, Khan MQ, Chakrabartty A, Pai EF.

Biochem Cell Biol. 2010 Apr;88(2):195-202. doi: 10.1139/o09-172. Review.

PMID:
20453922
[PubMed - indexed for MEDLINE]
13.

Autocatalytic conversion of recombinant prion proteins displays a species barrier.

Baskakov IV.

J Biol Chem. 2004 Feb 27;279(9):7671-7. Epub 2003 Dec 10.

PMID:
14668351
[PubMed - indexed for MEDLINE]
Free Article
14.

A role for His155 in binding of human prion peptide144-167 to immobilised prion protein.

Hesp JR, Raven ND, Sutton JM.

Biochem Biophys Res Commun. 2007 Oct 26;362(3):695-9. Epub 2007 Aug 17.

PMID:
17761148
[PubMed - indexed for MEDLINE]
15.

Exploring the propensities of helices in PrP(C) to form beta sheet using NMR structures and sequence alignments.

Dima RI, Thirumalai D.

Biophys J. 2002 Sep;83(3):1268-80.

PMID:
12202354
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The role of prion peptide structure and aggregation in toxicity and membrane binding.

Rymer DL, Good TA.

J Neurochem. 2000 Dec;75(6):2536-45.

PMID:
11080207
[PubMed - indexed for MEDLINE]
17.

A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH.

Hornemann S, Glockshuber R.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6010-4.

PMID:
9600908
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain.

Cobb NJ, Apetri AC, Surewicz WK.

J Biol Chem. 2008 Dec 12;283(50):34704-11. doi: 10.1074/jbc.M806701200. Epub 2008 Oct 17.

PMID:
18930924
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Introducing a rigid loop structure from deer into mouse prion protein increases its propensity for misfolding in vitro.

Kyle LM, John TR, Schätzl HM, Lewis RV.

PLoS One. 2013 Jun 25;8(6):e66715. doi: 10.1371/journal.pone.0066715. Print 2013.

PMID:
23825561
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Molecular dynamics studies on the NMR and X-ray structures of rabbit prion proteins.

Zhang J, Zhang Y.

J Theor Biol. 2014 Feb 7;342:70-82. doi: 10.1016/j.jtbi.2013.10.005. Epub 2013 Oct 31.

PMID:
24184221
[PubMed - indexed for MEDLINE]
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