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Results: 1 to 20 of 72

1.

HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression.

Conrad D, Wang A, Pieters R, Nicoletti F, Mangano K, van Heeckeren AM, White SK, Frincke JM, Reading CL, Stickney D, Auci DL.

J Inflamm (Lond). 2010 Oct 30;7:52. doi: 10.1186/1476-9255-7-52.

PMID:
21034489
[PubMed]
Free PMC Article
2.

An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis.

Offner H, Firestein GS, Boyle DL, Pieters R, Frincke JM, Garsd A, White SK, Reading CL, Auci DL.

J Pharmacol Exp Ther. 2009 Jun;329(3):1100-9. doi: 10.1124/jpet.108.145086. Epub 2009 Mar 18.

PMID:
19297421
[PubMed - indexed for MEDLINE]
Free Article
3.

Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene.

Ahlem CN, Kennedy MR, Page TM, Reading CL, White SK, McKenzie JJ, Cole PI, Stickney DR, Frincke JM.

Int J Clin Exp Med. 2011;4(2):119-35. Epub 2011 Apr 23.

PMID:
21686136
[PubMed]
Free PMC Article
4.

HE3286, an orally bioavailable synthetic analogue of an active DHEA metabolite suppresses spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse.

Kosiewicz MM, Auci DL, Fagone P, Mangano K, Caponnetto S, Tucker CF, Azeem N, White SK, Frincke JM, Reading CL, Nicoletti F.

Eur J Pharmacol. 2011 May 11;658(2-3):257-62. doi: 10.1016/j.ejphar.2011.02.016. Epub 2011 Mar 1.

PMID:
21371458
[PubMed - indexed for MEDLINE]
5.

HE3286: a novel synthetic steroid as an oral treatment for autoimmune disease.

Ahlem C, Auci D, Mangano K, Reading C, Frincke J, Stickney D, Nicoletti F.

Ann N Y Acad Sci. 2009 Sep;1173:781-90. doi: 10.1111/j.1749-6632.2009.04798.x.

PMID:
19758229
[PubMed - indexed for MEDLINE]
6.

Amelioration of glucose intolerance by the synthetic androstene HE3286: link to inflammatory pathways.

Wang T, Villegas S, Huang Y, White SK, Ahlem C, Lu M, Olefsky JM, Reading C, Frincke JM, Alleva D, Flores-Riveros J.

J Pharmacol Exp Ther. 2010 Apr;333(1):70-80. doi: 10.1124/jpet.109.161182. Epub 2010 Jan 12.

PMID:
20068030
[PubMed - indexed for MEDLINE]
Free Article
7.

Molecular targets for 17α-ethynyl-5-androstene-3β,7β,17β-triol, an anti-inflammatory agent derived from the human metabolome.

Reading CL, Frincke JM, White SK.

PLoS One. 2012;7(2):e32147. doi: 10.1371/journal.pone.0032147. Epub 2012 Feb 24.

PMID:
22384159
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease.

Nicoletti F, Philippens I, Fagone P, Ahlem CN, Reading CL, Frincke JM, Auci DL.

Parkinsons Dis. 2012;2012:969418. doi: 10.1155/2012/969418. Epub 2012 Sep 26.

PMID:
23050197
[PubMed]
Free PMC Article
9.

Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis.

Auci DL, Mangano K, Destiche D, White SK, Huang Y, Boyle D, Frincke J, Reading CL, Nicoletti F.

Int J Mol Med. 2010 Apr;25(4):625-33.

PMID:
20198312
[PubMed - indexed for MEDLINE]
10.

A potential role for 5-androstene-3β,7β,17β-triol in obesity and metabolic syndrome.

Auci DL, Ahlem CN, Kennedy MR, Page TM, Reading CL, Frincke JM.

Obesity (Silver Spring). 2011 Apr;19(4):806-11. doi: 10.1038/oby.2010.204. Epub 2010 Sep 16.

PMID:
20847733
[PubMed - indexed for MEDLINE]
11.

Anti-inflammatory and immune regulatory properties of 5-androsten-3beta, 17beta-diol (HE2100), and synthetic analogue HE3204: implications for treatment of autoimmune diseases.

Auci D, Nicoletti F, Mangano K, Pieters R, Nierkens S, Morgan L, Offner H, Frincke J, Reading C.

Ann N Y Acad Sci. 2005 Jun;1051:730-42.

PMID:
16127013
[PubMed - indexed for MEDLINE]
12.

Control of the immune response by DHEA and its metabolites.

Loria RM, Padgett DA.

Rinsho Byori. 1998 Jun;46(6):505-17.

PMID:
9691759
[PubMed - indexed for MEDLINE]
13.

Androstenetriol immunomodulation improves survival in a severe trauma hemorrhage shock model.

Marcu AC, Paccione KE, Barbee RW, Diegelmann RF, Ivatury RR, Ward KR, Loria RM.

J Trauma. 2007 Sep;63(3):662-9.

PMID:
18073617
[PubMed - indexed for MEDLINE]
14.

Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome.

Ahlem CN, Auci DL, Nicoletti F, Pieters R, Kennedy MR, Page TM, Reading CL, Enioutina EY, Frincke JM.

J Steroid Biochem Mol Biol. 2011 Sep;126(3-5):87-94. doi: 10.1016/j.jsbmb.2011.04.010. Epub 2011 May 5.

PMID:
21570467
[PubMed - indexed for MEDLINE]
15.

The anti-tumor effects of androstene steroids exhibit a strict structure-activity relationship dependent upon the orientation of the hydroxyl group on carbon-17.

Graf MR, Jia W, Lewbart ML, Loria RM.

Chem Biol Drug Des. 2009 Dec;74(6):625-9. doi: 10.1111/j.1747-0285.2009.00900.x. Epub 2009 Oct 12.

PMID:
19824892
[PubMed - indexed for MEDLINE]
16.

Absence of endogenous interleukin-10 enhances the evolution of acute lung injury.

Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Genovese T, De Sarro A, Caputi AP.

Eur Cytokine Netw. 2002 Jul-Sep;13(3):285-97.

PMID:
12231472
[PubMed - indexed for MEDLINE]
17.

Antiglucocorticoid function of androstenetriol.

Loria RM.

Psychoneuroendocrinology. 1997;22 Suppl 1:S103-8.

PMID:
9264155
[PubMed - indexed for MEDLINE]
18.

Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment.

Quinton LJ, Nelson S, Zhang P, Happel KI, Gamble L, Bagby GJ.

Alcohol Clin Exp Res. 2005 Jul;29(7):1198-205.

PMID:
16046875
[PubMed - indexed for MEDLINE]
19.

Regulation of the immune response by dehydroepiandrosterone and its metabolites.

Loria RM, Padgett DA, Huynh PN.

J Endocrinol. 1996 Sep;150 Suppl:S209-20.

PMID:
8943803
[PubMed - indexed for MEDLINE]
20.

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