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Results: 1 to 20 of 155

1.

Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor.

Massey AJ, Borgognoni J, Bentley C, Foloppe N, Fiumana A, Walmsley L.

PLoS One. 2010 Oct 18;5(10):e13123. doi: 10.1371/journal.pone.0013123.

PMID:
20976184
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1.

Blasina A, Hallin J, Chen E, Arango ME, Kraynov E, Register J, Grant S, Ninkovic S, Chen P, Nichols T, O'Connor P, Anderes K.

Mol Cancer Ther. 2008 Aug;7(8):2394-404. doi: 10.1158/1535-7163.MCT-07-2391.

PMID:
18723486
[PubMed - indexed for MEDLINE]
Free Article
4.

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

Walton MI, Eve PD, Hayes A, Valenti M, De Haven Brandon A, Box G, Boxall KJ, Aherne GW, Eccles SA, Raynaud FI, Williams DH, Reader JC, Collins I, Garrett MD.

Mol Cancer Ther. 2010 Jan;9(1):89-100. doi: 10.1158/1535-7163.MCT-09-0938. Epub 2010 Jan 6.

PMID:
20053762
[PubMed - indexed for MEDLINE]
Free Article
5.

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang JY, Sowin TJ, Rosenberg SH, Zhang H.

Int J Cancer. 2006 Dec 15;119(12):2784-94.

PMID:
17019715
[PubMed - indexed for MEDLINE]
6.

UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.

Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y.

Cancer Res. 2002 Oct 15;62(20):5743-8.

PMID:
12384533
[PubMed - indexed for MEDLINE]
Free Article
7.

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation.

Xiao Z, Xue J, Sowin TJ, Rosenberg SH, Zhang H.

Oncogene. 2005 Feb 17;24(8):1403-11.

PMID:
15608676
[PubMed - indexed for MEDLINE]
8.

Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350.

Yin MB, Guo B, Vanhoefer U, Azrak RG, Minderman H, Frank C, Wrzosek C, Slocum HK, Rustum YM.

Mol Pharmacol. 2000 Mar;57(3):453-9.

PMID:
10692484
[PubMed - indexed for MEDLINE]
Free Article
9.

DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2 arrest can occur independently of Chk1, Chk2 or MAPKAPK2.

Zhang WH, Poh A, Fanous AA, Eastman A.

Cell Cycle. 2008 Jun 1;7(11):1668-77. Epub 2008 Mar 23.

PMID:
18469532
[PubMed - indexed for MEDLINE]
Free Article
10.

Checkpoint kinase inhibitors: a review of the patent literature.

Janetka JW, Ashwell S.

Expert Opin Ther Pat. 2009 Feb;19(2):165-97. doi: 10.1517/13543770802653622. Review.

PMID:
19441917
[PubMed - indexed for MEDLINE]
11.

An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.

Jackson JR, Gilmartin A, Imburgia C, Winkler JD, Marshall LA, Roshak A.

Cancer Res. 2000 Feb 1;60(3):566-72.

PMID:
10676638
[PubMed - indexed for MEDLINE]
Free Article
12.

Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.

Aris SM, Pommier Y.

Cancer Res. 2012 Feb 15;72(4):979-89. doi: 10.1158/0008-5472.CAN-11-2579. Epub 2011 Dec 21. Erratum in: Cancer Res. 2012 Apr 15;72(8):2153-4.

PMID:
22189968
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe.

Evison BJ, Pastuovic M, Bilardi RA, Forrest RA, Pumuye PP, Sleebs BE, Watson KG, Phillips DR, Cutts SM.

Biochem Pharmacol. 2011 Dec 1;82(11):1604-18. doi: 10.1016/j.bcp.2011.08.013. Epub 2011 Aug 30.

PMID:
21889927
[PubMed - indexed for MEDLINE]
14.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.

Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM.

Mol Cancer Ther. 2008 Sep;7(9):2955-66. doi: 10.1158/1535-7163.MCT-08-0492.

PMID:
18790776
[PubMed - indexed for MEDLINE]
Free Article
15.

Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.

Lossaint G, Besnard E, Fisher D, Piette J, Dulić V.

Oncogene. 2011 Oct 13;30(41):4261-74. doi: 10.1038/onc.2011.135. Epub 2011 May 2.

PMID:
21532626
[PubMed - indexed for MEDLINE]
16.

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.

Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D.

Mol Cancer Ther. 2007 Mar;6(3):935-44.

PMID:
17363488
[PubMed - indexed for MEDLINE]
Free Article
17.

Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283.

Curry J, Angove H, Fazal L, Lyons J, Reule M, Thompson N, Wallis N.

Cell Cycle. 2009 Jun 15;8(12):1921-9. Epub 2009 Jun 15.

PMID:
19440047
[PubMed - indexed for MEDLINE]
Free Article
18.

Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.

Lee HJ, Hwang HI, Jang YJ.

Cell Cycle. 2010 Jun 15;9(12):2389-98. Epub 2010 Jun 15.

PMID:
20581453
[PubMed - indexed for MEDLINE]
Free Article
19.

RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.

Yan Y, Greer PM, Cao PT, Kolb RH, Cowan KH.

Breast Cancer Res. 2012 Apr 11;14(2):R60.

PMID:
22494620
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5159-64. doi: 10.1073/pnas.0806671106. Epub 2009 Mar 16.

PMID:
19289837
[PubMed - indexed for MEDLINE]
Free PMC Article

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