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Results: 1 to 20 of 98

1.

Inhibitors of anaplastic lymphoma kinase: a patent review.

Milkiewicz KL, Ott GR.

Expert Opin Ther Pat. 2010 Dec;20(12):1653-81. doi: 10.1517/13543776.2010.527332. Epub 2010 Oct 20. Review.

PMID:
20961208
[PubMed - indexed for MEDLINE]
2.

Anaplastic lymphoma kinase as a therapeutic target in anaplastic large cell lymphoma, non-small cell lung cancer and neuroblastoma.

Cheng M, Ott GR.

Anticancer Agents Med Chem. 2010 Mar;10(3):236-49. Review.

PMID:
20406193
[PubMed - indexed for MEDLINE]
3.

The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.

Kelleher FC, McDermott R.

Eur J Cancer. 2010 Sep;46(13):2357-68. doi: 10.1016/j.ejca.2010.04.006. Epub 2010 May 5. Review.

PMID:
20451371
[PubMed - indexed for MEDLINE]
4.

Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy.

Li R, Morris SW.

Med Res Rev. 2008 May;28(3):372-412. Review.

PMID:
17694547
[PubMed - indexed for MEDLINE]
5.

Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition.

Roskoski R Jr.

Pharmacol Res. 2013 Feb;68(1):68-94. doi: 10.1016/j.phrs.2012.11.007. Epub 2012 Nov 28. Review.

PMID:
23201355
[PubMed - indexed for MEDLINE]
6.

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW.

Expert Rev Anticancer Ther. 2009 Mar;9(3):331-56. doi: 10.1586/14737140.9.3.331. Review.

PMID:
19275511
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Antitumor activity of pyridoisoquinoline derivatives F91873 and F91874, novel multikinase inhibitors with activity against the anaplastic lymphoma kinase.

Kruczynski A, Mayer P, Marchand A, Vispé S, Fournier E, Annereau JP, Brel V, Barret JM, Delsol G, Imbert T, Fahy J, Bailly C.

Anticancer Drugs. 2009 Jun;20(5):364-72. doi: 10.1097/CAD.0b013e32832a2ed9.

PMID:
19322071
[PubMed - indexed for MEDLINE]
8.

Anaplastic lymphoma kinase as a therapeutic target.

Kruczynski A, Delsol G, Laurent C, Brousset P, Lamant L.

Expert Opin Ther Targets. 2012 Nov;16(11):1127-38. doi: 10.1517/14728222.2012.719498. Epub 2012 Sep 24. Review.

PMID:
22998583
[PubMed - indexed for MEDLINE]
9.

GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.

Sabbatini P, Korenchuk S, Rowand JL, Groy A, Liu Q, Leperi D, Atkins C, Dumble M, Yang J, Anderson K, Kruger RG, Gontarek RR, Maksimchuk KR, Suravajjala S, Lapierre RR, Shotwell JB, Wilson JW, Chamberlain SD, Rabindran SK, Kumar R.

Mol Cancer Ther. 2009 Oct;8(10):2811-20. doi: 10.1158/1535-7163.MCT-09-0423.

PMID:
19825801
[PubMed - indexed for MEDLINE]
Free Article
10.

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors.

McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J.

Cancer Res. 2008 May 1;68(9):3389-95. doi: 10.1158/0008-5472.CAN-07-6186.

PMID:
18451166
[PubMed - indexed for MEDLINE]
Free Article
11.

The ALK gene, an attractive target for inhibitor development.

Tartari CJ, Scapozza L, Gambacorti-Passerini C.

Curr Top Med Chem. 2011;11(11):1406-19. Review.

PMID:
21513493
[PubMed - indexed for MEDLINE]
12.

Cell culture modeling of genotype-directed sensitivity to selective kinase inhibitors: targeting the anaplastic lymphoma kinase (ALK).

Settleman J.

Semin Oncol. 2009 Apr;36(2 Suppl 1):S36-41. doi: 10.1053/j.seminoncol.2009.02.006.

PMID:
19393834
[PubMed - indexed for MEDLINE]
13.

Targeting anaplastic lymphoma kinase in lung cancer.

Shaw AT, Solomon B.

Clin Cancer Res. 2011 Apr 15;17(8):2081-6. doi: 10.1158/1078-0432.CCR-10-1591. Epub 2011 Feb 2. Review.

PMID:
21288922
[PubMed - indexed for MEDLINE]
Free Article
14.

The emerging normal and disease-related roles of anaplastic lymphoma kinase.

Pulford K, Lamant L, Espinos E, Jiang Q, Xue L, Turturro F, Delsol G, Morris SW.

Cell Mol Life Sci. 2004 Dec;61(23):2939-53. Review.

PMID:
15583856
[PubMed - indexed for MEDLINE]
15.

Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.

Schönherr C, Yang HL, Vigny M, Palmer RH, Hallberg B.

Oncogene. 2010 May 13;29(19):2817-30. doi: 10.1038/onc.2010.27. Epub 2010 Mar 1.

PMID:
20190816
[PubMed - indexed for MEDLINE]
16.

The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G.

Blood. 2009 Mar 19;113(12):2776-90. doi: 10.1182/blood-2008-06-161018. Epub 2008 Oct 9.

PMID:
18845790
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review.

Mesaros EF, Ott GR, Dorsey BD.

Expert Opin Ther Pat. 2014 Apr;24(4):417-42. doi: 10.1517/13543776.2014.877890. Epub 2014 Jan 30.

PMID:
24476492
[PubMed - in process]
18.

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase.

Milkiewicz KL, Weinberg LR, Albom MS, Angeles TS, Cheng M, Ghose AK, Roemmele RC, Theroff JP, Underiner TL, Zificsak CA, Dorsey BD.

Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. doi: 10.1016/j.bmc.2010.04.087. Epub 2010 Apr 29.

PMID:
20483621
[PubMed - indexed for MEDLINE]
19.

Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy.

Giuriato S, Faumont N, Bousquet E, Foisseau M, Bibonne A, Moreau M, Al Saati T, Felsher DW, Delsol G, Meggetto F.

Cancer Biol Ther. 2007 Aug;6(8):1318-23. Epub 2007 May 29.

PMID:
17660712
[PubMed - indexed for MEDLINE]
Free Article
20.

Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.

Ardini E, Magnaghi P, Orsini P, Galvani A, Menichincheri M.

Cancer Lett. 2010 Dec 28;299(2):81-94. doi: 10.1016/j.canlet.2010.09.001. Epub 2010 Oct 8. Review.

PMID:
20934803
[PubMed - indexed for MEDLINE]

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