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Items: 1 to 20 of 99


Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease.

Eubanks LM, Silhár P, Salzameda NT, Zakhari JS, Xiaochuan F, Barbieri JT, Shoemaker CB, Hixon MS, Janda KD.

ACS Med Chem Lett. 2010;1(6):268-272.


Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Šilhár P, Alakurtti S, Čapková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2229-31. doi: 10.1016/j.bmcl.2011.02.115. Epub 2011 Mar 4.


Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.

Li B, Cardinale SC, Butler MM, Pai R, Nuss JE, Peet NP, Bavari S, Bowlin TL.

Bioorg Med Chem. 2011 Dec 15;19(24):7338-48. doi: 10.1016/j.bmc.2011.10.062. Epub 2011 Oct 26.


Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library.

Miethe S, Rasetti-Escargueil C, Liu Y, Chahboun S, Pelat T, Avril A, Frenzel A, Schirrmann T, Thullier P, Sesardic D, Hust M.

MAbs. 2014 Mar-Apr;6(2):446-59. doi: 10.4161/mabs.27773. Epub 2014 Jan 9.


Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone Pharmacophore.

Burnett JC, Li B, Pai R, Cardinale SC, Butler MM, Peet NP, Moir D, Bavari S, Bowlin T.

Open Access Bioinformatics. 2010 Apr 1;2010(2):11-18.


Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD.

Bioorg Med Chem. 2013 Mar 1;21(5):1344-8. doi: 10.1016/j.bmc.2012.12.001. Epub 2012 Dec 20.


Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.

Teng YH, Berger WT, Nesbitt NM, Kumar K, Balius TE, Rizzo RC, Tonge PJ, Ojima I, Swaminathan S.

Bioorg Med Chem. 2015 Sep 1;23(17):5489-95. doi: 10.1016/j.bmc.2015.07.040. Epub 2015 Jul 27.


Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography.

Kumaran D, Adler M, Levit M, Krebs M, Sweeney R, Swaminathan S.

Bioorg Med Chem. 2015 Nov 15;23(22):7264-73. doi: 10.1016/j.bmc.2015.10.024. Epub 2015 Oct 17.


Mapping of the antibody-binding regions on botulinum neurotoxin H-chain domain 855-1296 with antitoxin antibodies from three host species.

Atassi MZ, Dolimbek BZ, Hayakari M, Middlebrook JL, Whitney B, Oshima M.

J Protein Chem. 1996 Oct;15(7):691-700.


Use of a recombinant fluorescent substrate with cleavage sites for all botulinum neurotoxins in high-throughput screening of natural product extracts for inhibitors of serotypes A, B, and E.

Hines HB, Kim AD, Stafford RG, Badie SS, Brueggeman EE, Newman DJ, Schmidt JJ.

Appl Environ Microbiol. 2008 Feb;74(3):653-9. Epub 2007 Dec 14.


Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Burnett JC, Schmidt JJ, McGrath CF, Nguyen TL, Hermone AR, Panchal RG, Vennerstrom JL, Kodukula K, Zaharevitz DW, Gussio R, Bavari S.

Bioorg Med Chem. 2005 Jan 17;13(2):333-41.


Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.

Boldt GE, Kennedy JP, Hixon MS, McAllister LA, Barbieri JT, Tzipori S, Janda KD.

J Comb Chem. 2006 Jul-Aug;8(4):513-21.


Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.

Thompson AA, Jiao GS, Kim S, Thai A, Cregar-Hernandez L, Margosiak SA, Johnson AT, Han GW, O'Malley S, Stevens RC.

Biochemistry. 2011 May 17;50(19):4019-28. doi: 10.1021/bi2001483. Epub 2011 Apr 21.


Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility.

Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN.

Chem Biol. 2007 May;14(5):533-42.


Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Burnett JC, Schmidt JJ, Stafford RG, Panchal RG, Nguyen TL, Hermone AR, Vennerstrom JL, McGrath CF, Lane DJ, Sausville EA, Zaharevitz DW, Gussio R, Bavari S.

Biochem Biophys Res Commun. 2003 Oct 10;310(1):84-93.


Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.

Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT.

Biochemistry. 2007 Sep 18;46(37):10685-93. Epub 2007 Aug 24.


Toosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).

Nakai Y, Pellett S, Tepp WH, Johnson EA, Janda KD.

Bioorg Med Chem. 2010 Feb;18(3):1280-7. doi: 10.1016/j.bmc.2009.12.030. Epub 2009 Dec 22. Erratum in: Bioorg Med Chem. 2011 Jul 1;19(13):4154.


Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.

Singh P, Singh MK, Chaudhary D, Chauhan V, Bharadwaj P, Pandey A, Upadhyay N, Dhaked RK.

PLoS One. 2012;7(10):e47110. doi: 10.1371/journal.pone.0047110. Epub 2012 Oct 11. Retraction in: PLoS One. 2013;8(9). doi: 10.1371/annotation/049f74d0-919f-483c-a488-4740ec0a5f4d.


Association of botulinum neurotoxin serotype A light chain with plasma membrane-bound SNAP-25.

Chen S, Barbieri JT.

J Biol Chem. 2011 Apr 29;286(17):15067-72. doi: 10.1074/jbc.M111.224493. Epub 2011 Mar 4.


A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic.

Wang J, Zurawski TH, Meng J, Lawrence G, Olango WM, Finn DP, Wheeler L, Dolly JO.

J Biol Chem. 2011 Feb 25;286(8):6375-85. doi: 10.1074/jbc.M110.181784. Epub 2010 Dec 7.

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