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Results: 1 to 20 of 128

1.

Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells.

Prill JM, Espenlaub S, Samen U, Engler T, Schmidt E, Vetrini F, Rosewell A, Grove N, Palmer D, Ng P, Kochanek S, Kreppel F.

Mol Ther. 2011 Jan;19(1):83-92. doi: 10.1038/mt.2010.229. Epub 2010 Oct 19.

PMID:
20959811
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus.

Doronin K, Shashkova EV, May SM, Hofherr SE, Barry MA.

Hum Gene Ther. 2009 Sep;20(9):975-88. doi: 10.1089/hum.2009.028.

PMID:
19469693
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer.

Khare R, May SM, Vetrini F, Weaver EA, Palmer D, Rosewell A, Grove N, Ng P, Barry MA.

Mol Ther. 2011 Jul;19(7):1254-62. doi: 10.1038/mt.2011.71. Epub 2011 Apr 19.

PMID:
21505422
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors.

Khare R, Reddy VS, Nemerow GR, Barry MA.

J Virol. 2012 Feb;86(4):2293-301. doi: 10.1128/JVI.05760-11. Epub 2011 Dec 7.

PMID:
22156515
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Circulating antibodies and macrophages as modulators of adenovirus pharmacology.

Khare R, Hillestad ML, Xu Z, Byrnes AP, Barry MA.

J Virol. 2013 Apr;87(7):3678-86. doi: 10.1128/JVI.01392-12. Epub 2013 Jan 16.

PMID:
23325678
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity.

Shayakhmetov DM, Gaggar A, Ni S, Li ZY, Lieber A.

J Virol. 2005 Jun;79(12):7478-91.

PMID:
15919903
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy.

Short JJ, Rivera AA, Wu H, Walter MR, Yamamoto M, Mathis JM, Curiel DT.

Mol Cancer Ther. 2010 Sep;9(9):2536-44. doi: 10.1158/1535-7163.MCT-10-0332. Epub 2010 Aug 24.

PMID:
20736345
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M, Alemany R, Hart IR.

Hum Gene Ther. 2012 Sep;23(9):960-79. doi: 10.1089/hum.2011.218. Epub 2012 Aug 27.

PMID:
22708837
[PubMed - indexed for MEDLINE]
10.

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats.

Nicol CG, Graham D, Miller WH, White SJ, Smith TA, Nicklin SA, Stevenson SC, Baker AH.

Mol Ther. 2004 Aug;10(2):344-54.

PMID:
15294181
[PubMed - indexed for MEDLINE]
11.

A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism.

Alberti MO, Deshane JS, Chaplin DD, Pereboeva L, Curiel DT, Roth JC.

Gene Ther. 2013 Jul;20(7):733-41. doi: 10.1038/gt.2012.91. Epub 2012 Nov 22.

PMID:
23171918
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver.

Vigant F, Descamps D, Jullienne B, Esselin S, Connault E, Opolon P, Tordjmann T, Vigne E, Perricaudet M, Benihoud K.

Mol Ther. 2008 Aug;16(8):1474-80. doi: 10.1038/mt.2008.132. Epub 2008 Jun 17.

PMID:
18560416
[PubMed - indexed for MEDLINE]
13.

Fiber shaft-chimeric adenovirus vectors lacking the KKTK motif efficiently infect liver cells in vivo.

Di Paolo NC, Kalyuzhniy O, Shayakhmetov DM.

J Virol. 2007 Nov;81(22):12249-59. Epub 2007 Sep 12.

PMID:
17855526
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Influence of fiber detargeting on adenovirus-mediated innate and adaptive immune activation.

Schoggins JW, Nociari M, Philpott N, Falck-Pedersen E.

J Virol. 2005 Sep;79(18):11627-37.

PMID:
16140740
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Reductive amination as a strategy to reduce adenovirus vector promiscuity by chemical capsid modification with large polysaccharides.

Espenlaub S, Wortmann A, Engler T, Corjon S, Kochanek S, Kreppel F.

J Gene Med. 2008 Dec;10(12):1303-14. doi: 10.1002/jgm.1262.

PMID:
18837065
[PubMed - indexed for MEDLINE]
16.

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction.

Suzuki-Kouyama E, Katayama K, Sakurai F, Yamaguchi T, Kurachi S, Kawabata K, Nakagawa S, Mizuguchi H.

Biomaterials. 2011 Feb;32(6):1724-30. doi: 10.1016/j.biomaterials.2010.10.060. Epub 2010 Nov 23.

PMID:
21106235
[PubMed - indexed for MEDLINE]
17.

PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver.

Croyle MA, Chirmule N, Zhang Y, Wilson JM.

Hum Gene Ther. 2002 Oct 10;13(15):1887-900.

PMID:
12396620
[PubMed - indexed for MEDLINE]
18.

Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors.

Shayakhmetov DM, Li ZY, Ni S, Lieber A.

J Virol. 2004 May;78(10):5368-81.

PMID:
15113916
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors.

Liu Q, Zaiss AK, Colarusso P, Patel K, Haljan G, Wickham TJ, Muruve DA.

Hum Gene Ther. 2003 May 1;14(7):627-43.

PMID:
12804145
[PubMed - indexed for MEDLINE]
20.

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.

Koizumi N, Mizuguchi H, Sakurai F, Yamaguchi T, Watanabe Y, Hayakawa T.

J Virol. 2003 Dec;77(24):13062-72.

PMID:
14645563
[PubMed - indexed for MEDLINE]
Free PMC Article
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