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Molecular dynamics simulations of Arp2/3 complex activation.

Dalhaimer P, Pollard TD.

Biophys J. 2010 Oct 20;99(8):2568-76. doi: 10.1016/j.bpj.2010.08.027.


An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability.

Goley ED, Rammohan A, Znameroski EA, Firat-Karalar EN, Sept D, Welch MD.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8159-64. doi: 10.1073/pnas.0911668107. Epub 2010 Apr 19.


Key structural features of the actin filament Arp2/3 complex branch junction revealed by molecular simulation.

Pfaendtner J, Volkmann N, Hanein D, Dalhaimer P, Pollard TD, Voth GA.

J Mol Biol. 2012 Feb 10;416(1):148-61. doi: 10.1016/j.jmb.2011.12.025. Epub 2011 Dec 17.


Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation.

Narayanan A, LeClaire LL 3rd, Barber DL, Jacobson MP.

PLoS Comput Biol. 2011 Nov;7(11):e1002226. doi: 10.1371/journal.pcbi.1002226. Epub 2011 Nov 10.


Crystal structure of Arp2/3 complex.

Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD.

Science. 2001 Nov 23;294(5547):1679-84.


The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation.

Balcer HI, Daugherty-Clarke K, Goode BL.

J Biol Chem. 2010 Mar 12;285(11):8481-91. doi: 10.1074/jbc.M109.054957. Epub 2010 Jan 12.


Molecular dynamics simulation and coarse-grained analysis of the Arp2/3 complex.

Pfaendtner J, Voth GA.

Biophys J. 2008 Dec;95(11):5324-33. doi: 10.1529/biophysj.108.143313. Epub 2008 Sep 19.


Influence of phalloidin on the formation of actin filament branches by Arp2/3 complex.

Mahaffy RE, Pollard TD.

Biochemistry. 2008 Jun 17;47(24):6460-7. doi: 10.1021/bi702484h. Epub 2008 May 20.


Characterization of two classes of small molecule inhibitors of Arp2/3 complex.

Nolen BJ, Tomasevic N, Russell A, Pierce DW, Jia Z, McCormick CD, Hartman J, Sakowicz R, Pollard TD.

Nature. 2009 Aug 20;460(7258):1031-4. doi: 10.1038/nature08231. Epub 2009 Aug 2.


Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.

Petchampai N, Sunyakumthorn P, Guillotte ML, Verhoeve VI, Banajee KH, Kearney MT, Macaluso KR.

PLoS One. 2014 Apr 14;9(4):e93768. doi: 10.1371/journal.pone.0093768. eCollection 2014.


Molecular analysis of Arp2/3 complex activation in cells.

Galletta BJ, Carlsson AE, Cooper JA.

Biophys J. 2012 Nov 21;103(10):2145-56. doi: 10.1016/j.bpj.2012.10.009. Epub 2012 Nov 20.


Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit.

Nolen BJ, Pollard TD.

J Biol Chem. 2008 Sep 26;283(39):26490-8. doi: 10.1074/jbc.M802607200. Epub 2008 Jul 18.


Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex.

Ti SC, Jurgenson CT, Nolen BJ, Pollard TD.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):E463-71. doi: 10.1073/pnas.1100125108. Epub 2011 Jun 15.


Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions.

Egile C, Rouiller I, Xu XP, Volkmann N, Li R, Hanein D.

PLoS Biol. 2005 Nov;3(11):e383. Epub 2005 Nov 8.


Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry.

Zencheck WD, Xiao H, Nolen BJ, Angeletti RH, Pollard TD, Almo SC.

J Mol Biol. 2009 Jul 17;390(3):414-27. doi: 10.1016/j.jmb.2009.03.028. Epub 2009 Mar 17.


Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry.

Kiselar JG, Mahaffy R, Pollard TD, Almo SC, Chance MR.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1552-7. Epub 2007 Jan 24.


Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis.

Daugherty KM, Goode BL.

J Biol Chem. 2008 Jun 13;283(24):16950-9. doi: 10.1074/jbc.M800783200. Epub 2008 Mar 31.


Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex.

Liu SL, May JR, Helgeson LA, Nolen BJ.

J Biol Chem. 2013 Jan 4;288(1):487-97. doi: 10.1074/jbc.M112.406744. Epub 2012 Nov 12.

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