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Results: 1 to 20 of 109

1.

Loss of tumor progression locus 2 (tpl2) enhances tumorigenesis and inflammation in two-stage skin carcinogenesis.

Decicco-Skinner KL, Trovato EL, Simmons JK, Lepage PK, Wiest JS.

Oncogene. 2011 Jan 27;30(4):389-97. doi: 10.1038/onc.2010.447. Epub 2010 Oct 11.

PMID:
20935675
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Altered prostanoid signaling contributes to increased skin tumorigenesis in Tpl2 knockout mice.

DeCicco-Skinner KL, Nolan SJ, Deshpande MM, Trovato EL, Dempsey TA, Wiest JS.

PLoS One. 2013;8(2):e56212. doi: 10.1371/journal.pone.0056212. Epub 2013 Feb 15.

PMID:
23457529
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Interleukin-17 induces AP-1 activity and cellular transformation via upregulation of tumor progression locus 2 activity.

Kim G, Khanal P, Lim SC, Yun HJ, Ahn SG, Ki SH, Choi HS.

Carcinogenesis. 2013 Feb;34(2):341-50. doi: 10.1093/carcin/bgs342. Epub 2012 Nov 3.

PMID:
23125217
[PubMed - indexed for MEDLINE]
Free Article
4.

Tpl2 is a key mediator of arsenite-induced signal transduction.

Lee KM, Lee KW, Bode AM, Lee HJ, Dong Z.

Cancer Res. 2009 Oct 15;69(20):8043-9. doi: 10.1158/0008-5472.CAN-09-2316. Epub 2009 Oct 6.

PMID:
19808956
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasis.

Decicco-Skinner KL, Jung SA, Tabib T, Gwilliam JC, Alexander H, Goodheart SE, Merchant AS, Shan M, Garber C, Wiest JS.

Carcinogenesis. 2013 Dec;34(12):2789-98. doi: 10.1093/carcin/bgt319. Epub 2013 Sep 25.

PMID:
24067898
[PubMed - indexed for MEDLINE]
6.

Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.

Koliaraki V, Roulis M, Kollias G.

J Clin Invest. 2012 Nov 1;122(11):4231-42. doi: 10.1172/JCI63917. Epub 2012 Oct 15.

PMID:
23064365
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.

Saleem M, Afaq F, Adhami VM, Mukhtar H.

Oncogene. 2004 Jul 1;23(30):5203-14.

PMID:
15122342
[PubMed - indexed for MEDLINE]
8.

All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.

Syed Z, Cheepala SB, Gill JN, Stein J, Nathan C, Digiovanni J, Batra V, Adegboyega P, Kleiner HE, Clifford JL.

Cancer Prev Res (Phila). 2009 Oct;2(10):903-11. doi: 10.1158/1940-6207.CAPR-09-0041. Epub 2009 Sep 29.

PMID:
19789299
[PubMed - indexed for MEDLINE]
9.

Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.

Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H.

Int J Cancer. 2005 Jan 20;113(3):423-33.

PMID:
15455341
[PubMed - indexed for MEDLINE]
10.

Tpl2 kinase signal transduction in inflammation and cancer.

Vougioukalaki M, Kanellis DC, Gkouskou K, Eliopoulos AG.

Cancer Lett. 2011 May 28;304(2):80-9. doi: 10.1016/j.canlet.2011.02.004. Epub 2011 Mar 5. Review.

PMID:
21377269
[PubMed - indexed for MEDLINE]
11.

Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion.

Cheepala SB, Yin W, Syed Z, Gill JN, McMillian A, Kleiner HE, Lynch M, Loganantharaj R, Trutschl M, Cvek U, Clifford JL.

Mol Cancer. 2009 May 11;8:27. doi: 10.1186/1476-4598-8-27.

PMID:
19432991
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease.

Lancaster GI, Kowalski GM, Estevez E, Kraakman MJ, Grigoriadis G, Febbraio MA, Gerondakis S, Banerjee A.

PLoS One. 2012;7(6):e39100. doi: 10.1371/journal.pone.0039100. Epub 2012 Jun 11.

PMID:
22701749
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin.

Guo H, Miao H, Gerber L, Singh J, Denning MF, Gilliam AC, Wang B.

Cancer Res. 2006 Jul 15;66(14):7050-8.

PMID:
16849550
[PubMed - indexed for MEDLINE]
Free Article
14.

Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.

Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin SM, Yen HC, Majima H, Hines J, St Clair D.

Cancer Res. 2001 Aug 15;61(16):6082-8.

PMID:
11507057
[PubMed - indexed for MEDLINE]
Free Article
15.

TPL2 kinase is a suppressor of lung carcinogenesis.

Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1470-9. doi: 10.1073/pnas.1215938110. Epub 2013 Mar 26.

PMID:
23533274
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis.

Kataoka K, Kim DJ, Carbajal S, Clifford JL, DiGiovanni J.

Carcinogenesis. 2008 Jun;29(6):1108-14. doi: 10.1093/carcin/bgn061. Epub 2008 May 2.

PMID:
18453544
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

IL-12 deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7,12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation.

Sharma SD, Meeran SM, Katiyar N, Tisdale GB, Yusuf N, Xu H, Elmets CA, Katiyar SK.

Carcinogenesis. 2009 Nov;30(11):1970-7. doi: 10.1093/carcin/bgp228. Epub 2009 Sep 16.

PMID:
19759192
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells.

Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ.

J Pharmacol Exp Ther. 2011 Sep;338(3):1013-22. doi: 10.1124/jpet.111.179200. Epub 2011 Jun 24.

PMID:
21705614
[PubMed - indexed for MEDLINE]
Free Article
20.

Cot/tpl2 (MAP3K8) mediates myeloperoxidase activity and hypernociception following peripheral inflammation.

Soria-Castro I, Krzyzanowska A, Pelaéz ML, Regadera J, Ferrer G, Montoliu L, Rodríguez-Ramos R, Fernández M, Alemany S.

J Biol Chem. 2010 Oct 29;285(44):33805-15. doi: 10.1074/jbc.M110.169409. Epub 2010 Aug 24.

PMID:
20736176
[PubMed - indexed for MEDLINE]
Free PMC Article

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