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Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE.

Cancer Res. 2010 Nov 15;70(22):9003-11. doi: 10.1158/0008-5472.CAN-10-2364. Epub 2010 Oct 8.


Physiological levels of resveratrol metabolites are ineffective as anti-leukemia agents against Jurkat leukemia cells.

Zunino SJ, Storms DH.

Nutr Cancer. 2015;67(2):266-74. doi: 10.1080/01635581.2015.989373. Epub 2015 Jan 26.


Resveratrol metabolism in a non-human primate, the grey mouse lemur (Microcebus murinus), using ultra-high-performance liquid chromatography-quadrupole time of flight.

Menet MC, Marchal J, Dal-Pan A, Taghi M, Nivet-Antoine V, Dargère D, Laprévote O, Beaudeux JL, Aujard F, Epelbaum J, Cottart CH.

PLoS One. 2014 Mar 24;9(3):e91932. doi: 10.1371/journal.pone.0091932. eCollection 2014.


Absorption and metabolism of piceatannol in rats.

Setoguchi Y, Oritani Y, Ito R, Inagaki H, Maruki-Uchida H, Ichiyanagi T, Ito T.

J Agric Food Chem. 2014 Mar 26;62(12):2541-8. doi: 10.1021/jf404694y. Epub 2014 Mar 13.


Pharmacokinetics and safety of resveratrol derivatives in humans after oral administration of melinjo (Gnetum gnemon L.) seed extract powder.

Tani H, Hikami S, Iizuna S, Yoshimatsu M, Asama T, Ota H, Kimura Y, Tatefuji T, Hashimoto K, Higaki K.

J Agric Food Chem. 2014 Feb 26;62(8):1999-2007. doi: 10.1021/jf4048435. Epub 2014 Feb 12.


Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats.

Bresciani L, Calani L, Bocchi L, Delucchi F, Savi M, Ray S, Brighenti F, Stilli D, Del Rio D.

Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):408-15. doi: 10.1016/j.numecd.2013.09.008. Epub 2013 Oct 23.


Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence.

Patel KR, Andreadi C, Britton RG, Horner-Glister E, Karmokar A, Sale S, Brown VA, Brenner DE, Singh R, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2013 Oct 2;5(205):205ra133. doi: 10.1126/scitranslmed.3005870.


Resveratrol in the management of human cancer: how strong is the clinical evidence?

Gescher A, Steward WP, Brown K.

Ann N Y Acad Sci. 2013 Jul;1290:12-20. doi: 10.1111/nyas.12205. Review.


Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents.

Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P.

Endocrinology. 2013 Oct;154(10):3739-44. doi: 10.1210/en.2012-2004. Epub 2013 Jul 8.


Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans.

Cottart CH, Nivet-Antoine V, Beaudeux JL.

Mol Nutr Food Res. 2014 Jan;58(1):7-21. doi: 10.1002/mnfr.201200589. Epub 2013 Jun 6. Review.


Insulin-like Growth Factor I and its binding protein 3 in sepsis.

Papastathi C, Mavrommatis A, Mentzelopoulos S, Konstandelou E, Alevizaki M, Zakynthinos S.

Growth Horm IGF Res. 2013 Aug;23(4):98-104. doi: 10.1016/j.ghir.2013.03.005. Epub 2013 Apr 21.


Helicobacter pylori eradication does not change circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 levels in patients with and without precancerous gastric lesions.

Ustundag Y, Sahin H, İlikhan S, Dogan BG, Kokturk F, Kar F.

Am J Med Sci. 2013 Nov;346(5):381-4. doi: 10.1097/MAJ.0b013e31827beed3.


Clinical value of circulating lipocalins and insulin-like growth factor axis in pancreatic cancer diagnosis.

El-Mesallamy HO, Hamdy NM, Zaghloul AS, Sallam AM.

Pancreas. 2013 Jan;42(1):149-54. doi: 10.1097/MPA.0b013e3182550d9d.


Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.

Saad SE, Jones DJ, Norris LM, Horner-Glister E, Patel KR, Britton RG, Steward WP, Gescher AJ, Brown K, Sale S.

Biomed Chromatogr. 2012 Dec;26(12):1559-66. doi: 10.1002/bmc.2732. Epub 2012 Mar 27.


Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs.

Muzzio M, Huang Z, Hu SC, Johnson WD, McCormick DL, Kapetanovic IM.

J Pharm Biomed Anal. 2012 Feb 5;59:201-8. doi: 10.1016/j.jpba.2011.10.023. Epub 2011 Oct 25.


Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2011 Sep;4(9):1419-25. doi: 10.1158/1940-6207.CAPR-11-0148. Epub 2011 Jun 16.


Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats.

Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL.

Cancer Chemother Pharmacol. 2011 Sep;68(3):593-601. doi: 10.1007/s00280-010-1525-4. Epub 2010 Nov 30.


Pharmacokinetic study of trans-resveratrol in adult pigs.

Azorín-Ortuño M, Yañéz-Gascón MJ, Pallarés FJ, Vallejo F, Larrosa M, García-Conesa MT, Tomás-Barberán F, Espín JC.

J Agric Food Chem. 2010 Oct 27;58(20):11165-71. doi: 10.1021/jf102799m. Epub 2010 Oct 1.


Effect of the somatostatin analog octreotide acetate on circulating insulin-like growth factor-1 and related peptides in patients with non-metastatic castration-resistant prostate cancer: results of a phase II study.

Friedlander TW, Weinberg VK, Small EJ, Sharib J, Harzstark AL, Lin AM, Fong L, Ryan CJ.

Urol Oncol. 2012 Jul-Aug;30(4):408-14. doi: 10.1016/j.urolonc.2010.06.014. Epub 2010 Oct 2.


Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K.

Cancer Res. 2010 Oct 1;70(19):7392-9. doi: 10.1158/0008-5472.CAN-10-2027. Epub 2010 Sep 14.

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