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Results: 1 to 20 of 114

1.

Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists.

Fritch PC, Krajewski J.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6375-8. doi: 10.1016/j.bmcl.2010.09.098. Epub 2010 Sep 19.

PMID:
20934333
[PubMed - indexed for MEDLINE]
2.

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

Smith EM, Sorota S, Kim HM, McKittrick BA, Nechuta TL, Bennett C, Knutson C, Burnett DA, Kieselgof J, Tan Z, Rindgen D, Bridal T, Zhou X, Jia YP, Dong Z, Mullins D, Zhang X, Priestley T, Correll CC, Tulshian D, Czarniecki M, Greenlee WJ.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4602-6. doi: 10.1016/j.bmcl.2010.06.012. Epub 2010 Jun 8.

PMID:
20580233
[PubMed - indexed for MEDLINE]
3.

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Hangeland JJ, Cheney DL, Friends TJ, Swartz S, Levesque PC, Rich AJ, Sun L, Bridal TR, Adam LP, Normandin DE, Murugesan N, Ewing WR.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):474-8. Epub 2007 Dec 3.

PMID:
18160281
[PubMed - indexed for MEDLINE]
4.

Synthesis and SAR study of T-type calcium channel blockers. Part II.

Choe YJ, Seo HN, Jung SY, Rhim H, Kim J, Choo DJ, Lee JY.

Arch Pharm (Weinheim). 2008 Oct;341(10):661-4. doi: 10.1002/ardp.200800079.

PMID:
18816587
[PubMed - indexed for MEDLINE]
5.

Investigation into the structure-activity relationship of novel concentration dependent, dual action T-type calcium channel agonists/antagonists.

McCalmont WF, Patterson JR, Lindenmuth MA, Heady TN, Haverstick DM, Gray LS, Macdonald TL.

Bioorg Med Chem. 2005 Jun 1;13(11):3821-39.

PMID:
15863008
[PubMed - indexed for MEDLINE]
6.

Structure-activity study of L-amino acid-based N-type calcium channel blockers.

Seko T, Kato M, Kohno H, Ono S, Hashimura K, Takimizu H, Nakai K, Maegawa H, Katsube N, Toda M.

Bioorg Med Chem. 2003 Apr 17;11(8):1901-13.

PMID:
12659776
[PubMed - indexed for MEDLINE]
7.

Synthesis and SAR studies of a novel series of T-type calcium channel blockers.

Park SJ, Park SJ, Lee MJ, Rhim H, Kim Y, Lee JH, Chung BY, Lee JY.

Bioorg Med Chem. 2006 May 15;14(10):3502-11. Epub 2006 Jan 24.

PMID:
16434203
[PubMed - indexed for MEDLINE]
8.

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.

Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, Connolly TM, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB, Woltmann RF, Magee MM, Koblan KS, Renger JJ.

J Med Chem. 2008 Oct 23;51(20):6471-7. doi: 10.1021/jm800830n. Epub 2008 Sep 26.

PMID:
18817368
[PubMed - indexed for MEDLINE]
9.

Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives.

Jo MN, Seo HJ, Kim Y, Seo SH, Rhim H, Cho YS, Cha JH, Koh HY, Choo H, Pae AN.

Bioorg Med Chem. 2007 Jan 1;15(1):365-73. Epub 2006 Oct 10.

PMID:
17035033
[PubMed - indexed for MEDLINE]
10.

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors.

Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F, Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch TP.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83. doi: 10.1016/j.bmcl.2010.01.008. Epub 2010 Jan 7.

PMID:
20117000
[PubMed - indexed for MEDLINE]
11.

Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.

Lee HK, Lee YS, Roh EJ, Rhim H, Lee JY, Shin KJ.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4424-7. doi: 10.1016/j.bmcl.2008.06.037. Epub 2008 Jun 14.

PMID:
18625556
[PubMed - indexed for MEDLINE]
12.

First pharmacophoric hypothesis for T-type calcium channel blockers.

Doddareddy MR, Jung HK, Lee JY, Lee YS, Cho YS, Koh HY, Pae AN.

Bioorg Med Chem. 2004 Apr 1;12(7):1605-11.

PMID:
15028253
[PubMed - indexed for MEDLINE]
13.

Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.

Seko T, Kato M, Kohno H, Ono S, Hashimura K, Takimizu H, Nakai K, Maegawa H, Katsube N, Toda M.

Bioorg Med Chem Lett. 2002 Mar 25;12(6):915-8.

PMID:
11958993
[PubMed - indexed for MEDLINE]
14.

Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.

Seko T, Kato M, Kohno H, Ono S, Hashimura K, Takimizu H, Nakai K, Maegawa H, Katsube N, Toda M.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2067-70.

PMID:
11514140
[PubMed - indexed for MEDLINE]
15.

Synthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity.

Kumar PP, Stotz SC, Paramashivappa R, Beedle AM, Zamponi GW, Rao AS.

Mol Pharmacol. 2002 Mar;61(3):649-58.

PMID:
11854446
[PubMed - indexed for MEDLINE]
Free Article
16.

Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist.

Yang H, Lin XF, Padilla F, Gabriel SD, Heilek G, Ji C, Sankuratri S, deRosier A, Berry P, Rotstein DM.

Bioorg Med Chem Lett. 2009 Jan 1;19(1):209-13. doi: 10.1016/j.bmcl.2008.10.115. Epub 2008 Oct 31.

PMID:
19014885
[PubMed - indexed for MEDLINE]
17.

Lead discovery and optimization of T-type calcium channel blockers.

Park JH, Choi JK, Lee E, Lee JK, Rhim H, Seo SH, Kim Y, Doddareddy MR, Pae AN, Kang J, Roh EJ.

Bioorg Med Chem. 2007 Feb 1;15(3):1409-19. Epub 2006 Nov 10.

PMID:
17150365
[PubMed - indexed for MEDLINE]
18.

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.

Schlegel KA, Yang ZQ, Reger TS, Shu Y, Cube R, Rittle KE, Bondiskey P, Bock MG, Hartman GD, Tang C, Ballard J, Kuo Y, Prueksaritanont T, Nuss CE, Doran SM, Fox SV, Garson SL, Kraus RL, Li Y, Uebele VN, Renger JJ, Barrow JC.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52. doi: 10.1016/j.bmcl.2010.07.010. Epub 2010 Jul 8.

PMID:
20673719
[PubMed - indexed for MEDLINE]
19.

Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.

Campiani G, Fiorini I, De Filippis MP, Ciani SM, Garofalo A, Nacci V, Giorgi G, Sega A, Botta M, Chiarini A, Budriesi R, Bruni G, Romeo MR, Manzoni C, Mennini T.

J Med Chem. 1996 Jul 19;39(15):2922-38.

PMID:
8709127
[PubMed - indexed for MEDLINE]
20.

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers.

Jung HK, Doddareddy MR, Cha JH, Rhim H, Cho YS, Koh HY, Jung BY, Pae AN.

Bioorg Med Chem. 2004 Aug 1;12(15):3965-70.

PMID:
15246072
[PubMed - indexed for MEDLINE]

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