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Items: 1 to 20 of 170

1.
2.

Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum.

Hickey MJ, Kwan RY, Awad MM, Kennedy CL, Young LF, Hall P, Cordner LM, Lyras D, Emmins JJ, Rood JI.

PLoS Pathog. 2008 Apr 11;4(4):e1000045. doi: 10.1371/journal.ppat.1000045.

4.

Sugar inhibits the production of the toxins that trigger clostridial gas gangrene.

Méndez MB, Goñi A, Ramirez W, Grau RR.

Microb Pathog. 2012 Jan;52(1):85-91. doi: 10.1016/j.micpath.2011.10.008. Epub 2011 Nov 4.

PMID:
22079896
5.

Mechanism of membrane damage by Clostridium perfringens alpha-toxin.

Nagahama M, Michiue K, Mukai M, Ochi S, Sakurai J.

Microbiol Immunol. 1998;42(8):533-8.

PMID:
9776394
7.

The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells.

Verherstraeten S, Goossens E, Valgaeren B, Pardon B, Timbermont L, Vermeulen K, Schauvliege S, Haesebrouck F, Ducatelle R, Deprez P, Van Immerseel F.

Vet Res. 2013 Jun 19;44:45. doi: 10.1186/1297-9716-44-45.

8.

Conformational changes that effect oligomerization and initiate pore formation are triggered throughout perfringolysin O upon binding to cholesterol.

Heuck AP, Savva CG, Holzenburg A, Johnson AE.

J Biol Chem. 2007 Aug 3;282(31):22629-37. Epub 2007 Jun 5.

9.

Membrane-damaging action of Clostridium perfringens alpha-toxin on phospholipid liposomes.

Nagahama M, Michiue K, Sakurai J.

Biochim Biophys Acta. 1996 Apr 3;1280(1):120-6.

10.

Enhanced production of phospholipase C and perfringolysin O (alpha and theta toxins) in a gatifloxacin-resistant strain of Clostridium perfringens.

Rafii F, Park M, Bryant AE, Johnson SJ, Wagner RD.

Antimicrob Agents Chemother. 2008 Mar;52(3):895-900. Epub 2007 Dec 26.

11.

Effect of lipidic factors on membrane cholesterol topology--mode of binding of theta-toxin to cholesterol in liposomes.

Ohno-Iwashita Y, Iwamoto M, Ando S, Iwashita S.

Biochim Biophys Acta. 1992 Aug 10;1109(1):81-90.

PMID:
1504083
12.

Structure of the key toxin in gas gangrene.

Naylor CE, Eaton JT, Howells A, Justin N, Moss DS, Titball RW, Basak AK.

Nat Struct Biol. 1998 Aug;5(8):738-46.

PMID:
9699639
13.
14.

Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding.

Titball RW, Naylor CE, Miller J, Moss DS, Basak AK.

Int J Med Microbiol. 2000 Oct;290(4-5):357-61. Review.

PMID:
11111911
15.

Modifications in perfringolysin O domain 4 alter the cholesterol concentration threshold required for binding.

Johnson BB, Moe PC, Wang D, Rossi K, Trigatti BL, Heuck AP.

Biochemistry. 2012 Apr 24;51(16):3373-82. doi: 10.1021/bi3003132. Epub 2012 Apr 13.

PMID:
22482748
16.

Cholesterol exposure at the membrane surface is necessary and sufficient to trigger perfringolysin O binding.

Flanagan JJ, Tweten RK, Johnson AE, Heuck AP.

Biochemistry. 2009 May 12;48(18):3977-87. doi: 10.1021/bi9002309.

18.

Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene.

Awad MM, Ellemor DM, Boyd RL, Emmins JJ, Rood JI.

Infect Immun. 2001 Dec;69(12):7904-10.

19.

Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain.

Vachieri SG, Clark GC, Alape-Girón A, Flores-Díaz M, Justin N, Naylor CE, Titball RW, Basak AK.

Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1067-74. doi: 10.1107/S090744491003369X. Epub 2010 Sep 18.

PMID:
20944240
20.

Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model.

Sayeed S, Uzal FA, Fisher DJ, Saputo J, Vidal JE, Chen Y, Gupta P, Rood JI, McClane BA.

Mol Microbiol. 2008 Jan;67(1):15-30.

PMID:
18078439
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