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Results: 1 to 20 of 95

1.

Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK.

PLoS One. 2010 Sep 20;5(9). pii: e12845. doi: 10.1371/journal.pone.0012845.

PMID:
20862226
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM.

Nature. 2009 Feb 26;457(7233):1128-32. doi: 10.1038/nature07761.

PMID:
19242475
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature.

Caccamo A, De Pinto V, Messina A, Branca C, Oddo S.

J Neurosci. 2014 Jun 4;34(23):7988-98. doi: 10.1523/JNEUROSCI.0777-14.2014.

PMID:
24899720
[PubMed - indexed for MEDLINE]
4.

Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.

Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magrí A, Oddo S.

J Biol Chem. 2011 Mar 18;286(11):8924-32. doi: 10.1074/jbc.M110.180638. Epub 2011 Jan 25.

PMID:
21266573
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aβ in vivo.

Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130147. doi: 10.1098/rstb.2013.0147. Print 2014 Jan 5.

PMID:
24298149
[PubMed - indexed for MEDLINE]
6.

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus.

Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72. Epub 2001 Dec 26.

PMID:
11756682
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways.

Lyu D, Yu W, Tang N, Wang R, Zhao Z, Xie F, He Y, Du H, Chen J.

Mol Pain. 2013 Dec 9;9:64. doi: 10.1186/1744-8069-9-64.

PMID:
24313960
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.

Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V.

PLoS One. 2010 Apr 1;5(4):e9979. doi: 10.1371/journal.pone.0009979. Erratum in: PLoS One. 2011;6(11). doi:10.1371/annotation/05c1b976-7eab-4154-808d-0526e604b8eb.

PMID:
20376313
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3.

Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD.

J Neurosci. 2011 Nov 30;31(48):17537-46. doi: 10.1523/JNEUROSCI.4761-11.2011.

PMID:
22131415
[PubMed - indexed for MEDLINE]
Free Article
10.

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

Rammes G, Hasenjäger A, Sroka-Saidi K, Deussing JM, Parsons CG.

Neuropharmacology. 2011 May;60(6):982-90. doi: 10.1016/j.neuropharm.2011.01.051. Epub 2011 Feb 12.

PMID:
21310164
[PubMed - indexed for MEDLINE]
11.

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.

Fu AK, Hung KW, Huang H, Gu S, Shen Y, Cheng EY, Ip FC, Huang X, Fu WY, Ip NY.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64. doi: 10.1073/pnas.1405803111. Epub 2014 Jun 23.

PMID:
24958880
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Synaptic changes in Alzheimer's disease and its models.

Pozueta J, Lefort R, Shelanski ML.

Neuroscience. 2013 Oct 22;251:51-65. doi: 10.1016/j.neuroscience.2012.05.050. Epub 2012 Jun 9. Review.

PMID:
22687952
[PubMed - indexed for MEDLINE]
13.

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Apr;113(1):248-61. doi: 10.1111/j.1471-4159.2010.06608.x. Epub 2010 Jan 20.

PMID:
20089133
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

Puzzo D, Vitolo O, Trinchese F, Jacob JP, Palmeri A, Arancio O.

J Neurosci. 2005 Jul 20;25(29):6887-97.

PMID:
16033898
[PubMed - indexed for MEDLINE]
Free Article
15.

Amyloid β-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide.

Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E.

J Neurosci. 2011 Apr 13;31(15):5589-95. doi: 10.1523/JNEUROSCI.6566-10.2011.

PMID:
21490199
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.

Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK.

PLoS One. 2013;8(1):e51965. doi: 10.1371/journal.pone.0051965. Epub 2013 Jan 23.

PMID:
23372648
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

Shipton OA, Leitz JR, Dworzak J, Acton CE, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M.

J Neurosci. 2011 Feb 2;31(5):1688-92. doi: 10.1523/JNEUROSCI.2610-10.2011.

PMID:
21289177
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Neurotrophins enhance CaMKII activity and rescue amyloid-β-induced deficits in hippocampal synaptic plasticity.

Zeng Y, Zhao D, Xie CW.

J Alzheimers Dis. 2010;21(3):823-31. doi: 10.3233/JAD-2010-100264.

PMID:
20634586
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.

Gengler S, Hamilton A, Hölscher C.

PLoS One. 2010 Mar 22;5(3):e9764. doi: 10.1371/journal.pone.0009764.

PMID:
20339537
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity.

Dong C, Bach SV, Haynes KA, Hegde AN.

J Neurosci. 2014 Feb 26;34(9):3171-82. doi: 10.1523/JNEUROSCI.3291-13.2014.

PMID:
24573276
[PubMed - indexed for MEDLINE]
Free PMC Article

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