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Items: 1 to 20 of 119


Sox2 activates cell proliferation and differentiation in the respiratory epithelium.

Tompkins DH, Besnard V, Lange AW, Keiser AR, Wert SE, Bruno MD, Whitsett JA.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):101-10. doi: 10.1165/rcmb.2010-0149OC. Epub 2010 Sep 20.


Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways.

Ustiyan V, Wert SE, Ikegami M, Wang IC, Kalin TV, Whitsett JA, Kalinichenko VV.

Dev Biol. 2012 Oct 15;370(2):198-212. doi: 10.1016/j.ydbio.2012.07.028. Epub 2012 Aug 2.


Multiple roles for Sox2 in the developing and adult mouse trachea.

Que J, Luo X, Schwartz RJ, Hogan BL.

Development. 2009 Jun;136(11):1899-907. doi: 10.1242/dev.034629. Epub 2009 Apr 29.


Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium.

Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA.

PLoS One. 2009 May 27;4(5):e5711. doi: 10.1371/journal.pone.0005711.


β-Catenin-SOX2 signaling regulates the fate of developing airway epithelium.

Hashimoto S, Chen H, Que J, Brockway BL, Drake JA, Snyder JC, Randell SH, Stripp BR.

J Cell Sci. 2012 Feb 15;125(Pt 4):932-42. doi: 10.1242/jcs.092734. Epub 2012 Mar 15.


Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells.

Tompkins DH, Besnard V, Lange AW, Wert SE, Keiser AR, Smith AN, Lang R, Whitsett JA.

PLoS One. 2009 Dec 14;4(12):e8248. doi: 10.1371/journal.pone.0008248.


Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia.

Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV.

Dev Biol. 2010 Nov 15;347(2):301-14. doi: 10.1016/j.ydbio.2010.08.027. Epub 2010 Sep 21.


Sox17 influences the differentiation of respiratory epithelial cells.

Park KS, Wells JM, Zorn AM, Wert SE, Whitsett JA.

Dev Biol. 2006 Jun 1;294(1):192-202. Epub 2006 Mar 30.


Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

Ochieng JK, Schilders K, Kool H, Boerema-De Munck A, Buscop-Van Kempen M, Gontan C, Smits R, Grosveld FG, Wijnen RM, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):311-22. doi: 10.1165/rcmb.2013-0419OC.


Transdifferentiation of ciliated cells during repair of the respiratory epithelium.

Park KS, Wells JM, Zorn AM, Wert SE, Laubach VE, Fernandez LG, Whitsett JA.

Am J Respir Cell Mol Biol. 2006 Feb;34(2):151-7. Epub 2005 Oct 20.


Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells.

You Y, Huang T, Richer EJ, Schmidt JE, Zabner J, Borok Z, Brody SL.

Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L650-7. Epub 2003 Jun 20.


SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production.

Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA.

J Clin Invest. 2009 Oct;119(10):2914-24. doi: 10.1172/JCI39731. Epub 2009 Sep 14.


Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation.

Hsu YC, Osinski J, Campbell CE, Litwack ED, Wang D, Liu S, Bachurski CJ, Gronostajski RM.

Dev Biol. 2011 Jun 15;354(2):242-52. doi: 10.1016/j.ydbio.2011.04.002. Epub 2011 Apr 13.


Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.

Liu Z, Walters BJ, Owen T, Brimble MA, Steigelman KA, Zhang L, Mellado Lagarde MM, Valentine MB, Yu Y, Cox BC, Zuo J.

J Neurosci. 2012 Aug 1;32(31):10530-40. doi: 10.1523/JNEUROSCI.0686-12.2012.


Sec14l3 is specifically expressed in mouse airway ciliated cells.

Shan L, Noritake S, Fujiwara M, Asano S, Yoshida-Noro C, Noro N, Yamashita K, Kawakami T.

Inflammation. 2012 Apr;35(2):702-12. doi: 10.1007/s10753-011-9363-z.


Wood smoke extract promotes both apoptosis and proliferation in rat alveolar epithelial type II cells: the role of oxidative stress and heme oxygenase-1.

Lee TS, Liu YJ, Tang GJ, Yien HW, Wu YL, Kou YR.

Crit Care Med. 2008 Sep;36(9):2597-606. doi: 10.1097/CCM.0b013e318184979c.


Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.

Huang Y, Kapere Ochieng J, Kempen MB, Munck AB, Swagemakers S, van Ijcken W, Grosveld F, Tibboel D, Rottier RJ.

PLoS One. 2013;8(2):e57695. doi: 10.1371/journal.pone.0057695. Epub 2013 Feb 25. Erratum in: PLoS One. 2015;10(3):e0119359.


SOX2 has a crucial role in the lineage determination and proliferation of mesenchymal stem cells through Dickkopf-1 and c-MYC.

Park SB, Seo KW, So AY, Seo MS, Yu KR, Kang SK, Kang KS.

Cell Death Differ. 2012 Mar;19(3):534-45. doi: 10.1038/cdd.2011.137. Epub 2011 Oct 21.


Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells.

Lee JH, Kim J, Gludish D, Roach RR, Saunders AH, Barrios J, Woo AJ, Chen H, Conner DA, Fujiwara Y, Stripp BR, Kim CF.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):288-98. doi: 10.1165/rcmb.2011-0403OC. Epub 2012 Nov 29.


Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction.

Horani A, Nath A, Wasserman MG, Huang T, Brody SL.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):341-7. doi: 10.1165/rcmb.2013-0046TE.

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