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Items: 1 to 20 of 85

1.

PERK in beta cell biology and insulin biogenesis.

Cavener DR, Gupta S, McGrath BC.

Trends Endocrinol Metab. 2010 Dec;21(12):714-21. doi: 10.1016/j.tem.2010.08.005. Epub 2010 Sep 17. Review.

2.
3.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

Gupta S, McGrath B, Cavener DR.

Diabetes. 2010 Aug;59(8):1937-47. doi: 10.2337/db09-1064. Epub 2010 Jun 8.

4.

Perk gene dosage regulates glucose homeostasis by modulating pancreatic β-cell functions.

Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR.

PLoS One. 2014 Jun 10;9(6):e99684. doi: 10.1371/journal.pone.0099684. eCollection 2014.

5.

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

Feng D, Wei J, Gupta S, McGrath BC, Cavener DR.

BMC Cell Biol. 2009 Sep 4;10:61. doi: 10.1186/1471-2121-10-61.

6.

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

Harding HP, Zyryanova AF, Ron D.

J Biol Chem. 2012 Dec 28;287(53):44338-44. doi: 10.1074/jbc.M112.428987. Epub 2012 Nov 12.

7.

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.

8.

The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.

Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K.

Cell Struct Funct. 2013;38(2):183-95. Epub 2013 Jun 28. Erratum in: Cell Struct Funct. 2014;39(1):21. Cell Struct Funct. 2013;38(2):227.

9.

PERK is required in the adult pancreas and is essential for maintenance of glucose homeostasis.

Gao Y, Sartori DJ, Li C, Yu QC, Kushner JA, Simon MC, Diehl JA.

Mol Cell Biol. 2012 Dec;32(24):5129-39. doi: 10.1128/MCB.01009-12. Epub 2012 Oct 15.

10.

PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice.

Gupta S, McGrath B, Cavener DR.

PLoS One. 2009 Nov 24;4(11):e8008. doi: 10.1371/journal.pone.0008008.

11.

Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content.

Yamani L, Latreille M, Larose L.

Mol Biol Cell. 2014 Mar;25(5):702-11. doi: 10.1091/mbc.E13-09-0511. Epub 2013 Dec 26.

12.

Mfn2 modulates the UPR and mitochondrial function via repression of PERK.

Muñoz JP, Ivanova S, Sánchez-Wandelmer J, Martínez-Cristóbal P, Noguera E, Sancho A, Díaz-Ramos A, Hernández-Alvarez MI, Sebastián D, Mauvezin C, Palacín M, Zorzano A.

EMBO J. 2013 Aug 28;32(17):2348-61. doi: 10.1038/emboj.2013.168. Epub 2013 Aug 6. Erratum in: EMBO J. 2014 Jan 13;33(2):171.

13.

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress.

Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A, Agostinis P.

Cell Death Differ. 2012 Nov;19(11):1880-91. doi: 10.1038/cdd.2012.74. Epub 2012 Jun 15.

14.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

15.

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells.

Linssen MM, van Raalte DH, Toonen EJ, Alkema W, van der Zon GC, Dokter WH, Diamant M, Guigas B, Ouwens DM.

Cell Signal. 2011 Nov;23(11):1708-15. doi: 10.1016/j.cellsig.2011.06.002. Epub 2011 Jun 13.

PMID:
21689745
16.

The endoplasmic reticulum stress response in the pancreatic β-cell.

Volchuk A, Ron D.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:48-57. doi: 10.1111/j.1463-1326.2010.01271.x. Review.

PMID:
21029300
17.

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

Diabetes. 2008 Nov;57(11):3034-44. doi: 10.2337/db07-1802. Epub 2008 Jun 30.

18.

PERK mediates cell-cycle exit during the mammalian unfolded protein response.

Brewer JW, Diehl JA.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12625-30.

19.

Pancreatic β-cells depend on basal expression of active ATF6α-p50 for cell survival even under nonstress conditions.

Teodoro T, Odisho T, Sidorova E, Volchuk A.

Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C992-1003. doi: 10.1152/ajpcell.00160.2011. Epub 2011 Dec 21.

20.

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.

Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC.

Mol Biol Cell. 2011 Nov;22(22):4390-405. doi: 10.1091/mbc.E11-06-0510. Epub 2011 Sep 14.

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