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Items: 1 to 20 of 172


Functional interactions between the LRP6 WNT co-receptor and folate supplementation.

Gray JD, Nakouzi G, Slowinska-Castaldo B, Dazard JE, Rao JS, Nadeau JH, Ross ME.

Hum Mol Genet. 2010 Dec 1;19(23):4560-72. doi: 10.1093/hmg/ddq384. Epub 2010 Sep 15.


LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.

Gray JD, Kholmanskikh S, Castaldo BS, Hansler A, Chung H, Klotz B, Singh S, Brown AM, Ross ME.

Hum Mol Genet. 2013 Nov 1;22(21):4267-81. doi: 10.1093/hmg/ddt277. Epub 2013 Jun 16.


Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

Carter M, Chen X, Slowinska B, Minnerath S, Glickstein S, Shi L, Campagne F, Weinstein H, Ross ME.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12843-8. Epub 2005 Aug 26.


Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway.

Allache R, Lachance S, Guyot MC, De Marco P, Merello E, Justice MJ, Capra V, Kibar Z.

Hum Mol Genet. 2014 Apr 1;23(7):1687-99. doi: 10.1093/hmg/ddt558. Epub 2013 Nov 7. Erratum in: Hum Mol Genet. 2014 Aug 1;23(15):4185.


Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies.

Han M, Serrano MC, Lastra-Vicente R, Brinez P, Acharya G, Huhta JC, Chen R, Linask KK.

Dis Model Mech. 2009 Sep-Oct;2(9-10):467-78. doi: 10.1242/dmm.001438. Epub 2009 Jul 28.


The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.

Bryja V, Andersson ER, Schambony A, Esner M, Bryjov√° L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E.

Mol Biol Cell. 2009 Feb;20(3):924-36. doi: 10.1091/mbc.E08-07-0711. Epub 2008 Dec 3.


Crooked tail (Cd) models human folate-responsive neural tube defects.

Carter M, Ulrich S, Oofuji Y, Williams DA, Ross ME.

Hum Mol Genet. 1999 Nov;8(12):2199-204.


Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

MacDonald BT, Yokota C, Tamai K, Zeng X, He X.

J Biol Chem. 2008 Jun 6;283(23):16115-23. doi: 10.1074/jbc.M800327200. Epub 2008 Mar 24.


Genetic interaction between Lrp6 and Wnt5a during mouse development.

Andersson ER, Bryjova L, Biris K, Yamaguchi TP, Arenas E, Bryja V.

Dev Dyn. 2010 Jan;239(1):237-45. doi: 10.1002/dvdy.22101.


Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway.

Mi K, Johnson GV.

J Cell Biochem. 2005 May 15;95(2):328-38.


Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.

Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M.

PLoS One. 2010 Sep 13;5(9):e12682. doi: 10.1371/journal.pone.0012682.


Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice.

Ernest S, Carter M, Shao H, Hosack A, Lerner N, Colmenares C, Rosenblatt DS, Pao YH, Ross ME, Nadeau JH.

Hum Mol Genet. 2006 Dec 1;15(23):3387-93. Epub 2006 Oct 18.


Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.

Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R.

J Bone Miner Res. 2006 Nov;21(11):1738-49.


The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.

Lindvall C, Zylstra CR, Evans N, West RA, Dykema K, Furge KA, Williams BO.

PLoS One. 2009 Jun 5;4(6):e5813. doi: 10.1371/journal.pone.0005813.


Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion.

Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ.

Development. 2009 Sep;136(18):3161-71. doi: 10.1242/dev.037440.


The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

Kelly OG, Pinson KI, Skarnes WC.

Development. 2004 Jun;131(12):2803-15. Epub 2004 May 13.


Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.

Marean A, Graf A, Zhang Y, Niswander L.

Hum Mol Genet. 2011 Sep 15;20(18):3678-83. doi: 10.1093/hmg/ddr289. Epub 2011 Jun 21.


Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Goel S, Chin EN, Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM.

J Biol Chem. 2012 May 11;287(20):16454-66. doi: 10.1074/jbc.M112.362137. Epub 2012 Mar 20.


Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

Nam JS, Turcotte TJ, Smith PF, Choi S, Yoon JK.

J Biol Chem. 2006 May 12;281(19):13247-57. Epub 2006 Mar 16.

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