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Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.

Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL.

Gastroenterology. 2010 Dec;139(6):2170-82. doi: 10.1053/j.gastro.2010.09.002. Epub 2010 Sep 15.


Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development.

Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY.

Hepatology. 2012 Dec;56(6):2255-67. doi: 10.1002/hep.26007.


The critical role of AKT2 in hepatic steatosis induced by PTEN loss.

He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL.

Am J Pathol. 2010 May;176(5):2302-8. doi: 10.2353/ajpath.2010.090931. Epub 2010 Mar 26.


Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation.

Utley S, James D, Mavila N, Nguyen MV, Vendryes C, Salisbury SM, Phan J, Wang KS.

J Hepatol. 2014 May;60(5):1002-9. doi: 10.1016/j.jhep.2013.12.017. Epub 2013 Dec 21.


The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.

Cancer Res. 2010 Jul 1;70(13):5305-15. doi: 10.1158/0008-5472.CAN-09-3399. Epub 2010 Jun 8.


Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Schultze SM, Dietrich M, Hynx D, Geier A, Niessen M, Spinas GA, Hemmings BA, Tschopp O.

Liver Int. 2015 Apr;35(4):1354-66. doi: 10.1111/liv.12600. Epub 2014 Jun 24.


Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice.

Wang C, Yang W, Yan HX, Luo T, Zhang J, Tang L, Wu FQ, Zhang HL, Yu LX, Zheng LY, Li YQ, Dong W, He YQ, Liu Q, Zou SS, Lin Y, Hu L, Li Z, Wu MC, Wang HY.

Hepatology. 2012 Jan;55(1):108-20. doi: 10.1002/hep.24675. Epub 2011 Dec 6.


Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.

Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS.

PLoS Biol. 2009 Jun 2;7(6):e1000121. doi: 10.1371/journal.pbio.1000121. Epub 2009 Jun 2.


Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice.

Rountree CB, Ding W, He L, Stiles B.

Stem Cells. 2009 Feb;27(2):290-9. doi: 10.1634/stemcells.2008-0332.


The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.

Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA.

Gastroenterology. 2010 Jan;138(1):241-54. doi: 10.1053/j.gastro.2009.08.064. Epub 2009 Sep 6.


PTEN-deficient tumors depend on AKT2 for maintenance and survival.

Chin YR, Yuan X, Balk SP, Toker A.

Cancer Discov. 2014 Aug;4(8):942-55. doi: 10.1158/2159-8290.CD-13-0873. Epub 2014 May 16.


Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency.

Guo SL, Ye H, Teng Y, Wang YL, Yang G, Li XB, Zhang C, Yang X, Yang ZZ, Yang X.

Nat Commun. 2013;4:2544. doi: 10.1038/ncomms3544.


Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis.

Zhao H, Cui Y, Dupont J, Sun H, Hennighausen L, Yakar S.

Cancer Res. 2005 Aug 1;65(15):6864-73.


GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.

Chen WT, Zhu G, Pfaffenbach K, Kanel G, Stiles B, Lee AS.

Oncogene. 2014 Oct 16;33(42):4997-5005. doi: 10.1038/onc.2013.437. Epub 2013 Oct 21.


Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.

Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z.

Development. 2015 Feb 15;142(4):732-42. doi: 10.1242/dev.119016.


TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation.

Morris SM, Carter KT, Baek JY, Koszarek A, Yeh MM, Knoblaugh SE, Grady WM.

Oncogene. 2015 Jun;34(25):3273-82. doi: 10.1038/onc.2014.258. Epub 2014 Aug 18.


PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling.

Conley-LaComb MK, Saliganan A, Kandagatla P, Chen YQ, Cher ML, Chinni SR.

Mol Cancer. 2013 Jul 31;12(1):85. doi: 10.1186/1476-4598-12-85.


Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.

Vilgelm A, Lian Z, Wang H, Beauparlant SL, Klein-Szanto A, Ellenson LH, Di Cristofano A.

Cancer Res. 2006 Apr 1;66(7):3375-80.


Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.

Taniai E, Kawai M, Dewa Y, Nishimura J, Harada T, Saegusa Y, Matsumoto S, Takahashi M, Mitsumori K, Shibutani M.

Cancer Sci. 2009 May;100(5):813-20. doi: 10.1111/j.1349-7006.2009.01120.x. Epub 2009 Mar 20.


TSC1/TSC2 inactivation inhibits AKT through mTORC1-dependent up-regulation of STAT3-PTEN cascade.

Zha X, Hu Z, He S, Wang F, Shen H, Zhang H.

Cancer Lett. 2011 Dec 27;313(2):211-7. doi: 10.1016/j.canlet.2011.09.006. Epub 2011 Sep 12.

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