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The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.

Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O.

BMC Ophthalmol. 2010 Sep 13;10:22. doi: 10.1186/1471-2415-10-22.


Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.

Prasanthi JR, Larson T, Schommer J, Ghribi O.

PLoS One. 2011;6(10):e26420. doi: 10.1371/journal.pone.0026420. Epub 2011 Oct 14.


Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina.

Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O.

BMC Ophthalmol. 2011 Aug 18;11:22. doi: 10.1186/1471-2415-11-22.


Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.

Marwarha G, Raza S, Prasanthi JR, Ghribi O.

PLoS One. 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773. eCollection 2013.


Protective effect of canolol from oxidative stress-induced cell damage in ARPE-19 cells via an ERK mediated antioxidative pathway.

Dong X, Li Z, Wang W, Zhang W, Liu S, Zhang X, Fang J, Maeda H, Matsukura M.

Mol Vis. 2011;17:2040-8. Epub 2011 Jul 27. Erratum in: Mol Vis. 2014;20:283. Fang, Jun [added]; Maeda, Hiroshi [added]; Matsukura, Makoto [added].


Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.

Marwarha G, Dasari B, Prasanthi JR, Schommer J, Ghribi O.

J Alzheimers Dis. 2010;19(3):1007-19. doi: 10.3233/JAD-2010-1298.


DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE).

Shadrach KG, Rayborn ME, Hollyfield JG, Bonilha VL.

PLoS One. 2013 Jul 2;8(7):e67983. doi: 10.1371/journal.pone.0067983. Print 2013. Erratum in: PLoS One. 2014;9(7):104292.


Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.

Dasari B, Prasanthi JR, Meiers C, Singh BB, Ghribi O.

Curr Eye Res. 2013 Nov;38(11):1159-71. doi: 10.3109/02713683.2013.811257. Epub 2013 Jul 10.


Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells.

Bruban J, Glotin AL, Dinet V, Chalour N, Sennlaub F, Jonet L, An N, Faussat AM, Mascarelli F.

Aging Cell. 2009 Apr;8(2):162-77. doi: 10.1111/j.1474-9726.2009.00456.x. Epub 2009 Feb 23.


Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration.

Bertram KM, Baglole CJ, Phipps RP, Libby RT.

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1200-10. doi: 10.1152/ajpcell.00126.2009. Epub 2009 Sep 16.


Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells.

Feng J, Chen X, Sun X, Wang F, Sun X.

Ophthalmic Res. 2014;52(4):224-33. doi: 10.1159/000363387. Epub 2014 Nov 12.


The pathogenic role of the canonical Wnt pathway in age-related macular degeneration.

Zhou T, Hu Y, Chen Y, Zhou KK, Zhang B, Gao G, Ma JX.

Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4371-9. doi: 10.1167/iovs.09-4278. Epub 2009 Oct 29.


The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells.

Ma WW, Li CQ, Yu HL, Zhang DD, Xi YD, Han J, Liu QR, Xiao R.

Neurochem Res. 2015 Apr;40(4):758-66. doi: 10.1007/s11064-015-1524-2. Epub 2015 Jan 29.


The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells.

Lau LI, Chiou SH, Liu CJ, Yen MY, Wei YH.

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. doi: 10.1167/iovs.11-7815.


Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime.

Gamba P, Leonarduzzi G, Tamagno E, Guglielmotto M, Testa G, Sottero B, Gargiulo S, Biasi F, Mauro A, Viña J, Poli G.

Aging Cell. 2011 Jun;10(3):403-17. doi: 10.1111/j.1474-9726.2011.00681.x. Epub 2011 Apr 5.


Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress.

Yoshikawa T, Ogata N, Izuta H, Shimazawa M, Hara H, Takahashi K.

Curr Eye Res. 2011 Dec;36(12):1153-63. doi: 10.3109/02713683.2011.606592. Epub 2011 Oct 6.


Iron increases APP translation and amyloid-beta production in the retina.

Guo LY, Alekseev O, Li Y, Song Y, Dunaief JL.

Exp Eye Res. 2014 Dec;129:31-7. doi: 10.1016/j.exer.2014.10.012. Epub 2014 Oct 16.


Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration.

Hadziahmetovic M, Song Y, Wolkow N, Iacovelli J, Kautz L, Roth MP, Dunaief JL.

Am J Pathol. 2011 Jul;179(1):335-48. doi: 10.1016/j.ajpath.2011.03.033. Epub 2011 May 3.


Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress.

Biasutto L, Chiechi A, Couch R, Liotta LA, Espina V.

Exp Cell Res. 2013 Aug 1;319(13):2113-23. doi: 10.1016/j.yexcr.2013.05.005. Epub 2013 May 10.

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