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Results: 1 to 20 of 146

1.

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L.

PLoS Genet. 2010 Sep 2;6(9):e1001087. doi: 10.1371/journal.pgen.1001087. Erratum in: PLoS Genet. 2012 Jan;8(1). doi: 10.1371/annotation/baa8a2a9-130b-4959-b6fb-6f786fd02826.

PMID:
20824130
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3.

Koh SH, Noh MY, Kim SH.

Brain Res. 2008 Jan 10;1188:254-62. Epub 2007 Nov 1.

PMID:
18031715
[PubMed - indexed for MEDLINE]
3.

Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease.

Folwell J, Cowan CM, Ubhi KK, Shiabh H, Newman TA, Shepherd D, Mudher A.

Exp Neurol. 2010 Jun;223(2):401-9. doi: 10.1016/j.expneurol.2009.09.014. Epub 2009 Sep 24.

PMID:
19782075
[PubMed - indexed for MEDLINE]
4.

Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.

Iijima K, Gatt A, Iijima-Ando K.

Hum Mol Genet. 2010 Aug 1;19(15):2947-57. doi: 10.1093/hmg/ddq200. Epub 2010 May 12.

PMID:
20466736
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

Onishi T, Iwashita H, Uno Y, Kunitomo J, Saitoh M, Kimura E, Fujita H, Uchiyama N, Kori M, Takizawa M.

J Neurochem. 2011 Dec;119(6):1330-40. doi: 10.1111/j.1471-4159.2011.07532.x. Epub 2011 Nov 2.

PMID:
21992552
[PubMed - indexed for MEDLINE]
6.

Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E.

J Neurosci. 2007 Feb 21;27(8):1981-91.

PMID:
17314294
[PubMed - indexed for MEDLINE]
Free Article
7.

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

Serenó L, Coma M, Rodríguez M, Sánchez-Ferrer P, Sánchez MB, Gich I, Agulló JM, Pérez M, Avila J, Guardia-Laguarta C, Clarimón J, Lleó A, Gómez-Isla T.

Neurobiol Dis. 2009 Sep;35(3):359-67. doi: 10.1016/j.nbd.2009.05.025. Epub 2009 Jun 10.

PMID:
19523516
[PubMed - indexed for MEDLINE]
8.

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.

Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, Jung YK.

Hum Mol Genet. 2012 Jun 15;21(12):2725-37. doi: 10.1093/hmg/dds100. Epub 2012 Mar 13.

PMID:
22419736
[PubMed - indexed for MEDLINE]
Free Article
9.

The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.

Lanzillotta A, Sarnico I, Benarese M, Branca C, Baiguera C, Hutter-Paier B, Windisch M, Spano P, Imbimbo BP, Pizzi M.

J Mol Neurosci. 2011 Sep;45(1):22-31. doi: 10.1007/s12031-010-9482-2. Epub 2010 Dec 22.

PMID:
21181298
[PubMed - indexed for MEDLINE]
10.

Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons.

Zhang Z, Zhao R, Qi J, Wen S, Tang Y, Wang D.

J Neurosci Res. 2011 Mar;89(3):437-47. doi: 10.1002/jnr.22563. Epub 2010 Dec 17.

PMID:
21259330
[PubMed - indexed for MEDLINE]
11.

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Phiel CJ, Wilson CA, Lee VM, Klein PS.

Nature. 2003 May 22;423(6938):435-9.

PMID:
12761548
[PubMed - indexed for MEDLINE]
12.

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

Chauhan NB, Siegel GJ, Feinstein DL.

Neuropharmacology. 2005 Jan;48(1):93-104.

PMID:
15617731
[PubMed - indexed for MEDLINE]
13.

Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors.

Avila J, Wandosell F, Hernández F.

Expert Rev Neurother. 2010 May;10(5):703-10. doi: 10.1586/ern.10.40.

PMID:
20420491
[PubMed - indexed for MEDLINE]
14.

Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Cai Z, Zhao Y, Zhao B.

Curr Alzheimer Res. 2012 Sep;9(7):864-79. Review.

PMID:
22272620
[PubMed - indexed for MEDLINE]
15.

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease.

Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L.

Front Aging Neurosci. 2014 Jul 30;6:190. doi: 10.3389/fnagi.2014.00190. eCollection 2014.

PMID:
25126078
[PubMed]
Free PMC Article
16.

Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.

Chatterjee S, Sang TK, Lawless GM, Jackson GR.

Hum Mol Genet. 2009 Jan 1;18(1):164-77. doi: 10.1093/hmg/ddn326. Epub 2008 Oct 17.

PMID:
18930955
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila.

Iijima-Ando K, Hearn SA, Granger L, Shenton C, Gatt A, Chiang HC, Hakker I, Zhong Y, Iijima K.

J Biol Chem. 2008 Jul 4;283(27):19066-76. doi: 10.1074/jbc.M710509200. Epub 2008 May 7.

PMID:
18463098
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.

PMID:
16511867
[PubMed - indexed for MEDLINE]
19.
20.

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE.

J Neurosci. 2008 Mar 5;28(10):2624-32. doi: 10.1523/JNEUROSCI.5245-07.2008.

PMID:
18322105
[PubMed - indexed for MEDLINE]
Free Article

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