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Results: 1 to 20 of 134

1.

Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition.

Barnes EA, Kenerson HL, Jiang X, Yeung RS.

Am J Pathol. 2010 Oct;177(4):1765-78. doi: 10.2353/ajpath.2010.090233. Epub 2010 Sep 2.

PMID:
20813961
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells.

Lesma E, Sirchia SM, Ancona S, Carelli S, Bosari S, Ghelma F, Montanari E, Di Giulio AM, Gorio A.

Am J Pathol. 2009 Jun;174(6):2150-9. doi: 10.2353/ajpath.2009.080799. Epub 2009 May 14.

PMID:
19443708
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.

PMID:
19593385
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development.

Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Li B, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H.

Oncogene. 2013 Sep 26;32(39):4702-11. doi: 10.1038/onc.2012.481. Epub 2012 Oct 29.

PMID:
23108404
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Insight into mechanism of oxidative DNA damage in angiomyolipomas from TSC patients.

Habib SL.

Mol Cancer. 2009 Mar 5;8:13. doi: 10.1186/1476-4598-8-13.

PMID:
19265534
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. Possible treatment options for TSC and LAM.

Lesma E, Grande V, Ancona S, Carelli S, Di Giulio AM, Gorio A.

PLoS One. 2008;3(10):e3558. doi: 10.1371/journal.pone.0003558. Epub 2008 Oct 29.

PMID:
18958173
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells.

Kim EY, Kim A, Kim SK, Kim HJ, Chang J, Ahn CM, Chang YS.

Respir Res. 2014 Feb 26;15:26. doi: 10.1186/1465-9921-15-26.

PMID:
24571487
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.

Robb VA, Astrinidis A, Henske EP.

Mod Pathol. 2006 Jun;19(6):839-46. Erratum in: Mod Pathol. 2006 Jun;19(6):889.

PMID:
16575396
[PubMed - indexed for MEDLINE]
Free Article
9.

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.

Lin CY, Hsu SC, Lee HS, Lin SH, Tsai CS, Huang SM, Shih CC, Hsu YJ.

J Vasc Surg. 2013 Feb;57(2):475-85. doi: 10.1016/j.jvs.2012.07.037. Epub 2012 Dec 21.

PMID:
23265586
[PubMed - indexed for MEDLINE]
10.

The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma.

Johnson SR, Clelland CA, Ronan J, Tattersfield AE, Knox AJ.

Histopathology. 2002 May;40(5):458-63.

PMID:
12010366
[PubMed - indexed for MEDLINE]
11.

Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation.

Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA Jr, Krymskaya VP.

Mol Pharmacol. 2008 Mar;73(3):778-88. Epub 2007 Dec 19.

PMID:
18094073
[PubMed - indexed for MEDLINE]
Free Article
12.

Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways.

Ogunwobi OO, Liu C.

Clin Exp Metastasis. 2011 Dec;28(8):721-31. doi: 10.1007/s10585-011-9404-x. Epub 2011 Jul 10.

PMID:
21744257
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.

Siroky BJ, Yin H, Babcock JT, Lu L, Hellmann AR, Dixon BP, Quilliam LA, Bissler JJ.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F831-44. doi: 10.1152/ajprenal.00441.2011. Epub 2012 Jul 11.

PMID:
22791333
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells.

Habib SL, Bhandari BK, Sadek N, Abboud-Werner SL, Abboud HE.

Carcinogenesis. 2010 Nov;31(11):2022-30. doi: 10.1093/carcin/bgq189. Epub 2010 Sep 13.

PMID:
20837600
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling.

Atochina-Vasserman EN, Goncharov DA, Volgina AV, Milavec M, James ML, Krymskaya VP.

Am J Respir Cell Mol Biol. 2013 Nov;49(5):704-9. doi: 10.1165/rcmb.2013-0203RC.

PMID:
23947572
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Renal disease in adults with TSC2/PKD1 contiguous gene syndrome.

Martignoni G, Bonetti F, Pea M, Tardanico R, Brunelli M, Eble JN.

Am J Surg Pathol. 2002 Feb;26(2):198-205.

PMID:
11812941
[PubMed - indexed for MEDLINE]
17.

Activation of AKT signaling promotes epithelial-mesenchymal transition and tumor growth in colorectal cancer cells.

Suman S, Kurisetty V, Das TP, Vadodkar A, Ramos G, Lakshmanaswamy R, Damodaran C.

Mol Carcinog. 2014 Feb;53 Suppl 1:E151-60. doi: 10.1002/mc.22076. Epub 2013 Sep 2.

PMID:
24000138
[PubMed - indexed for MEDLINE]
18.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.

PMID:
15342917
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

TSC2 deficiency increases PTEN via HIF1alpha.

Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G.

J Biol Chem. 2009 Oct 9;284(41):27790-8. doi: 10.1074/jbc.M109.028860. Epub 2009 Jul 31.

PMID:
19648120
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.

Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW; TCGA Research Network, Gan B.

Oncogene. 2014 Jun 12;33(24):3183-94. doi: 10.1038/onc.2013.273. Epub 2013 Jul 15.

PMID:
23851496
[PubMed - indexed for MEDLINE]

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