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Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos.

Zakin L, Chang EY, Plouhinec JL, De Robertis EM.

Dev Biol. 2010 Nov 1;347(1):204-15. doi: 10.1016/j.ydbio.2010.08.025. Epub 2010 Aug 31.


Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation.

Zakin L, Metzinger CA, Chang EY, Coffinier C, De Robertis EM.

Dev Biol. 2008 Nov 1;323(1):6-18. doi: 10.1016/j.ydbio.2008.08.019. Epub 2008 Aug 29.


Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.

Ambrosio AL, Taelman VF, Lee HX, Metzinger CA, Coffinier C, De Robertis EM.

Dev Cell. 2008 Aug;15(2):248-60. doi: 10.1016/j.devcel.2008.06.013.


Binding between Crossveinless-2 and Chordin von Willebrand factor type C domains promotes BMP signaling by blocking Chordin activity.

Zhang JL, Patterson LJ, Qiu LY, Graziussi D, Sebald W, Hammerschmidt M.

PLoS One. 2010 Sep 23;5(9):e12846. doi: 10.1371/journal.pone.0012846.


Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice.

Ikeya M, Nosaka T, Fukushima K, Kawada M, Furuta Y, Kitamura T, Sasai Y.

Mech Dev. 2008 Sep-Oct;125(9-10):832-42. doi: 10.1016/j.mod.2008.06.011. Epub 2008 Jul 3.


von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms.

Zhang JL, Huang Y, Qiu LY, Nickel J, Sebald W.

J Biol Chem. 2007 Jul 6;282(27):20002-14. Epub 2007 May 4.


Twisted gastrulation and chordin inhibit differentiation and mineralization in MC3T3-E1 osteoblast-like cells.

Petryk A, Shimmi O, Jia X, Carlson AE, Tervonen L, Jarcho MP, O'connor MB, Gopalakrishnan R.

Bone. 2005 Apr;36(4):617-26.


Crossveinless-2 controls bone morphogenetic protein signaling during early cardiomyocyte differentiation in P19 cells.

Harada K, Ogai A, Takahashi T, Kitakaze M, Matsubara H, Oh H.

J Biol Chem. 2008 Sep 26;283(39):26705-13. doi: 10.1074/jbc.M801485200. Epub 2008 Jul 28.


BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment.

Mine N, Anderson RM, Klingensmith J.

Development. 2008 Aug;135(14):2425-34. doi: 10.1242/dev.018986. Epub 2008 Jun 11.


Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin.

Jasuja R, Allen BL, Pappano WN, Rapraeger AC, Greenspan DS.

J Biol Chem. 2004 Dec 3;279(49):51289-97. Epub 2004 Sep 20.


Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.

Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y.

Development. 2006 Nov;133(22):4463-73. Epub 2006 Oct 11.


Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.

Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y.

Dev Biol. 2010 Jan 15;337(2):405-14. doi: 10.1016/j.ydbio.2009.11.013. Epub 2009 Nov 13.


Crossveinless 2 regulates bone morphogenetic protein 9 in human and mouse vascular endothelium.

Yao Y, Jumabay M, Ly A, Radparvar M, Wang AH, Abdmaulen R, Boström KI.

Blood. 2012 May 24;119(21):5037-47. doi: 10.1182/blood-2011-10-385906. Epub 2012 Apr 3.


Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms.

Xie J, Fisher S.

Development. 2005 Jan;132(2):383-91. Epub 2004 Dec 16.


Patterning the zebrafish axial skeleton requires early chordin function.

Fisher S, Halpern ME.

Nat Genet. 1999 Dec;23(4):442-6.


Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect.

van der Zee M, Stockhammer O, von Levetzow C, Nunes da Fonseca R, Roth S.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16307-12. Epub 2006 Oct 18.


The pro-BMP activity of Twisted gastrulation is independent of BMP binding.

Oelgeschläger M, Reversade B, Larraín J, Little S, Mullins MC, De Robertis EM.

Development. 2003 Sep;130(17):4047-56.

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