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Results: 1 to 20 of 99

1.

Inhibition of human peptide deformylase disrupts mitochondrial function.

Escobar-Alvarez S, Gardner J, Sheth A, Manfredi G, Yang G, Ouerfelli O, Heaney ML, Scheinberg DA.

Mol Cell Biol. 2010 Nov;30(21):5099-109. doi: 10.1128/MCB.00469-10. Epub 2010 Aug 30.

PMID:
20805355
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.

Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA.

J Clin Invest. 2004 Oct;114(8):1107-16.

PMID:
15489958
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure and activity of human mitochondrial peptide deformylase, a novel cancer target.

Escobar-Alvarez S, Goldgur Y, Yang G, Ouerfelli O, Li Y, Scheinberg DA.

J Mol Biol. 2009 Apr 17;387(5):1211-28. doi: 10.1016/j.jmb.2009.02.032. Epub 2009 Feb 21.

PMID:
19236878
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inhibition of human mitochondrial peptide deformylase causes apoptosis in c-myc-overexpressing hematopoietic cancers.

Sheth A, Escobar-Alvarez S, Gardner J, Ran L, Heaney ML, Scheinberg DA.

Cell Death Dis. 2014 Mar 27;5:e1152. doi: 10.1038/cddis.2014.112.

PMID:
24675470
[PubMed - in process]
Free PMC Article
5.

Characterization of a human peptide deformylase: implications for antibacterial drug design.

Nguyen KT, Hu X, Colton C, Chakrabarti R, Zhu MX, Pei D.

Biochemistry. 2003 Aug 26;42(33):9952-8.

PMID:
12924944
[PubMed - indexed for MEDLINE]
6.
7.

High-throughput identification of inhibitors of human mitochondrial peptide deformylase.

Antczak C, Shum D, Escobar S, Bassit B, Kim E, Seshan VE, Wu N, Yang G, Ouerfelli O, Li YM, Scheinberg DA, Djaballah H.

J Biomol Screen. 2007 Jun;12(4):521-35. Epub 2007 Apr 13.

PMID:
17435169
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure.

Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A.

PLoS One. 2010 Aug 24;5(8):e12359. doi: 10.1371/journal.pone.0012359.

PMID:
20808761
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A new human peptide deformylase inhibitable by actinonin.

Lee MD, Antczak C, Li Y, Sirotnak FM, Bornmann WG, Scheinberg DA.

Biochem Biophys Res Commun. 2003 Dec 12;312(2):309-15.

PMID:
14637138
[PubMed - indexed for MEDLINE]
10.

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.

Whitaker-Menezes D, Martinez-Outschoorn UE, Flomenberg N, Birbe RC, Witkiewicz AK, Howell A, Pavlides S, Tsirigos A, Ertel A, Pestell RG, Broda P, Minetti C, Lisanti MP, Sotgia F.

Cell Cycle. 2011 Dec 1;10(23):4047-64. doi: 10.4161/cc.10.23.18151. Epub 2011 Dec 1.

PMID:
22134189
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs.

Smeitink JA, Elpeleg O, Antonicka H, Diepstra H, Saada A, Smits P, Sasarman F, Vriend G, Jacob-Hirsch J, Shaag A, Rechavi G, Welling B, Horst J, Rodenburg RJ, van den Heuvel B, Shoubridge EA.

Am J Hum Genet. 2006 Nov;79(5):869-77. Epub 2006 Sep 15.

PMID:
17033963
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mitochondrial DNA background modulates the assembly kinetics of OXPHOS complexes in a cellular model of mitochondrial disease.

Pello R, Martín MA, Carelli V, Nijtmans LG, Achilli A, Pala M, Torroni A, Gómez-Durán A, Ruiz-Pesini E, Martinuzzi A, Smeitink JA, Arenas J, Ugalde C.

Hum Mol Genet. 2008 Dec 15;17(24):4001-11. doi: 10.1093/hmg/ddn303. Epub 2008 Sep 19.

PMID:
18806273
[PubMed - indexed for MEDLINE]
Free Article
13.

Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth.

Jeng JY, Yeh TS, Lee JW, Lin SH, Fong TH, Hsieh RH.

J Cell Biochem. 2008 Feb 1;103(2):347-57.

PMID:
18072287
[PubMed - indexed for MEDLINE]
14.

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning.

Stetler RA, Leak RK, Yin W, Zhang L, Wang S, Gao Y, Chen J.

J Neurochem. 2012 Nov;123 Suppl 2:125-37. doi: 10.1111/j.1471-4159.2012.07951.x.

PMID:
23050650
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Contributions of glycolysis and oxidative phosphorylation to adenosine 5'-triphosphate production in AS-30D hepatoma cells.

Nakashima RA, Paggi MG, Pedersen PL.

Cancer Res. 1984 Dec;44(12 Pt 1):5702-6.

PMID:
6498833
[PubMed - indexed for MEDLINE]
Free Article
16.

Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption.

McKenzie M, Liolitsa D, Akinshina N, Campanella M, Sisodiya S, Hargreaves I, Nirmalananthan N, Sweeney MG, Abou-Sleiman PM, Wood NW, Hanna MG, Duchen MR.

J Biol Chem. 2007 Dec 21;282(51):36845-52. Epub 2007 Oct 16.

PMID:
17940288
[PubMed - indexed for MEDLINE]
Free Article
17.

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency.

Coenen MJ, Antonicka H, Ugalde C, Sasarman F, Rossi R, Heister JG, Newbold RF, Trijbels FJ, van den Heuvel LP, Shoubridge EA, Smeitink JA.

N Engl J Med. 2004 Nov 11;351(20):2080-6.

PMID:
15537906
[PubMed - indexed for MEDLINE]
Free Article
18.

Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain.

Senapedis WT, Kennedy CJ, Boyle PM, Silver PA.

Mol Biol Cell. 2011 May 15;22(10):1791-805. doi: 10.1091/mbc.E10-10-0854. Epub 2011 Apr 1.

PMID:
21460183
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

ATP synthesis, mitochondrial function, and steroid biosynthesis in rodent primary and tumor Leydig cells.

Midzak AS, Chen H, Aon MA, Papadopoulos V, Zirkin BR.

Biol Reprod. 2011 May;84(5):976-85. doi: 10.1095/biolreprod.110.087460. Epub 2011 Jan 12.

PMID:
21228212
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The A3243G tRNALeu(UUR) MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2.

Sasarman F, Antonicka H, Shoubridge EA.

Hum Mol Genet. 2008 Dec 1;17(23):3697-707. doi: 10.1093/hmg/ddn265. Epub 2008 Aug 27.

PMID:
18753147
[PubMed - indexed for MEDLINE]
Free Article

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