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1.

Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial.

Matucci-Cerinic M, Denton CP, Furst DE, Mayes MD, Hsu VM, Carpentier P, Wigley FM, Black CM, Fessler BJ, Merkel PA, Pope JE, Sweiss NJ, Doyle MK, Hellmich B, Medsger TA Jr, Morganti A, Kramer F, Korn JH, Seibold JR.

Ann Rheum Dis. 2011 Jan;70(1):32-8. doi: 10.1136/ard.2010.130658. Epub 2010 Aug 30.

2.

Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.

Korn JH, Mayes M, Matucci Cerinic M, Rainisio M, Pope J, Hachulla E, Rich E, Carpentier P, Molitor J, Seibold JR, Hsu V, Guillevin L, Chatterjee S, Peter HH, Coppock J, Herrick A, Merkel PA, Simms R, Denton CP, Furst D, Nguyen N, Gaitonde M, Black C.

Arthritis Rheum. 2004 Dec;50(12):3985-93.

3.

[Treatment of digital ulcers in systemtic sclerosis with endothelin-1 receptor antagonist (bosentan)].

Riccardi MT, Chialà A, Lannone F, Grattagliano V, Covelli M, Lapadula G.

Reumatismo. 2007 Apr-Jun;59(2):135-9. Italian.

PMID:
17603693
4.

Digital ulcers: overt vascular disease in systemic sclerosis.

Steen V, Denton CP, Pope JE, Matucci-Cerinic M.

Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii19-24. doi: 10.1093/rheumatology/kep105. Review.

5.

Use of bosentan for digital ulcers related to systemic sclerosis: a real-life retrospective French study of 89 patients treated since specific approval.

Agard C, Carpentier PH, Mouthon L, Clerson P, Gressin V, Bérezné A, Diot E, Jego P, Lok C, Sparsa A, Chatelus E, Van Kien AK, Quéré I, Sibilia J, Hachulla E.

Scand J Rheumatol. 2014;43(5):398-402. doi: 10.3109/03009742.2014.887768. Epub 2014 Apr 11.

PMID:
24720440
6.

Digital ulcers and outcomes assessment in scleroderma.

Matucci-Cerinic M, Seibold JR.

Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v46-7. doi: 10.1093/rheumatology/ken310. Review.

7.

Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial.

Kuhn A, Haust M, Ruland V, Weber R, Verde P, Felder G, Ohmann C, Gensch K, Ruzicka T.

Rheumatology (Oxford). 2010 Jul;49(7):1336-45. doi: 10.1093/rheumatology/keq077. Epub 2010 Apr 5.

8.

Bosentan for digital ulcers in patients with systemic sclerosis.

Nagai Y, Hasegawa M, Hattori T, Okada E, Tago O, Ishikawa O.

J Dermatol. 2012 Jan;39(1):48-51. doi: 10.1111/j.1346-8138.2011.01299.x. Epub 2011 Sep 28.

PMID:
21955007
9.

Effect of the dual endothelin receptor antagonist bosentan on Raynaud's phenomenon secondary to systemic sclerosis: a double-blind prospective, randomized, placebo-controlled pilot study.

Nguyen VA, Eisendle K, Gruber I, Hugl B, Reider D, Reider N.

Rheumatology (Oxford). 2010 Mar;49(3):583-7. doi: 10.1093/rheumatology/kep413. Epub 2009 Dec 29.

10.

Low occurrence of digital ulcers in scleroderma patients treated with bosentan for pulmonary arterial hypertension: a retrospective case-control study.

Cozzi F, Pigatto E, Rizzo M, Favaro M, Zanatta E, Cardarelli S, Riato L, Punzi L.

Clin Rheumatol. 2013 May;32(5):679-83. doi: 10.1007/s10067-013-2172-z. Epub 2013 Jan 24.

PMID:
23344686
11.

[Bosentan for treatment of active digital ulcers in patients with systemic sclerosis].

Launay D, Diot E, Pasquier E, Mouthon L, Boullanger N, Fain O, Jego P, Carpentier P, Hatron PY, Hachulla E.

Presse Med. 2006 Apr;35(4 Pt 1):587-92. French.

12.

Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis.

Dhillon S.

Drugs. 2009 Oct 1;69(14):2005-24. doi: 10.2165/10489160-000000000-00000. Review.

PMID:
19747014
13.

Blood flow in the hands of a predefined homogeneous systemic sclerosis population: the presence of digital ulcers and the improvement with bosentan.

Meijs J, Voskuyl AE, Bloemsaat-Minekus JP, Vonk MC.

Rheumatology (Oxford). 2015 Feb;54(2):262-9. doi: 10.1093/rheumatology/keu300. Epub 2014 Aug 22.

PMID:
25150178
14.

New hope for systemic sclerosis patients with digital ulcers.

Varga J.

Curr Rheumatol Rep. 2005 Apr;7(2):127-8. No abstract available.

PMID:
15760591
15.

Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study.

Brueckner CS, Becker MO, Kroencke T, Huscher D, Scherer HU, Worm M, Burmester G, Riemekasten G.

Ann Rheum Dis. 2010 Aug;69(8):1475-8. doi: 10.1136/ard.2009.116475. Epub 2009 Nov 8.

16.

Management of digital vasculopathy in systemic sclerosis: benefits of multiple courses of endothelin-1 receptor antagonists.

Ngcozana T, Ong V, Denton CP.

BMJ Case Rep. 2014 Mar 28;2014. pii: bcr2013203174. doi: 10.1136/bcr-2013-203174.

PMID:
24682137
17.

Meta-analysis of healing and prevention of digital ulcers in systemic sclerosis.

Tingey T, Shu J, Smuczek J, Pope J.

Arthritis Care Res (Hoboken). 2013 Sep;65(9):1460-71. doi: 10.1002/acr.22018.

PMID:
23554239
18.

Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients.

García de la Peña-Lefebvre P, Rodríguez Rubio S, Valero Expósito M, Carmona L, Gámir Gámir ML, Beltrán Gutiérrez J, Díaz-Miguel C, Orte Martínez J, Zea Mendoza AC.

Rheumatology (Oxford). 2008 Apr;47(4):464-6. doi: 10.1093/rheumatology/ken001. Epub 2008 Feb 7.

19.

[Digital ulcers in systemic sclerosis: use of endotheline antagonists].

Mota J, Castellano A, Santiago F, Carvalho P, Madeira AS, Pereira De Moura JM, Nascimento Costa JM.

Acta Med Port. 2011 Sep-Oct;24(5):837-42. Epub 2011 Dec 29. Portuguese.

20.

Bosentan in clinical practice for treating digital and other ischemic ulcers in Spanish patients with systemic sclerosis: IBER-DU cohort study.

Roman Ivorra JA, Simeon CP, Alegre Sancho JJ, Egurbide MV, Castillo MJ, Lloria X, Fonollosa V.

J Rheumatol. 2011 Aug;38(8):1631-5. doi: 10.3899/jrheum.101266. Epub 2011 Jun 1.

PMID:
21632679
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