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Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.

Takai H, Xie Y, de Lange T, Pavletich NP.

Genes Dev. 2010 Sep 15;24(18):2019-30. doi: 10.1101/gad.1956410. Epub 2010 Aug 27.


Tel2 regulates the stability of PI3K-related protein kinases.

Takai H, Wang RC, Takai KK, Yang H, de Lange T.

Cell. 2007 Dec 28;131(7):1248-59.


CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

Horejsí Z, Takai H, Adelman CA, Collis SJ, Flynn H, Maslen S, Skehel JM, de Lange T, Boulton SJ.

Mol Cell. 2010 Sep 24;39(6):839-50. doi: 10.1016/j.molcel.2010.08.037.


Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1.

Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH, Prodromou C.

Structure. 2014 Jun 10;22(6):805-18. doi: 10.1016/j.str.2014.04.001. Epub 2014 May 1.


Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

Anderson CM, Korkin D, Smith DL, Makovets S, Seidel JJ, Sali A, Blackburn EH.

Genes Dev. 2008 Apr 1;22(7):854-9. doi: 10.1101/gad.1646208. Epub 2008 Mar 11.


Hsp90 picks PIKKs via R2TP and Tel2.

Vaughan CK.

Structure. 2014 Jun 10;22(6):799-800. doi: 10.1016/j.str.2014.05.012.


Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex.

Izumi N, Yamashita A, Hirano H, Ohno S.

Cancer Sci. 2012 Jan;103(1):50-7. doi: 10.1111/j.1349-7006.2011.02112.x. Epub 2011 Oct 24.


Mec1 function in the DNA damage response does not require its interaction with Tel2.

Anderson CM, Blackburn EH.

Cell Cycle. 2008 Dec;7(23):3695-8. Epub 2008 Dec 7.


Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated.

Rozario D, Siede W.

Biochem Biophys Res Commun. 2012 Jan 27;417(4):1182-7. doi: 10.1016/j.bbrc.2011.12.103. Epub 2011 Dec 29.


Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.

Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N.

J Biol Chem. 2010 Jun 25;285(26):20109-16. doi: 10.1074/jbc.M110.121699. Epub 2010 Apr 28.


Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development.

Moser SC, von Elsner S, Büssing I, Alpi A, Schnabel R, Gartner A.

PLoS Genet. 2009 Apr;5(4):e1000451. doi: 10.1371/journal.pgen.1000451. Epub 2009 Apr 10. Erratum in: PLoS Genet. 2011 May;7(5). doi:10.1371/annotation/5c0706a8-a9c2-452a-b061-a7c60dbc0499.


A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

Hurov KE, Cotta-Ramusino C, Elledge SJ.

Genes Dev. 2010 Sep 1;24(17):1939-50. doi: 10.1101/gad.1934210.


Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

Hoffman KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ.

G3 (Bethesda). 2016 Jun 1;6(6):1649-59. doi: 10.1534/g3.116.029520.


SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.

Fernández-Sáiz V, Targosz BS, Lemeer S, Eichner R, Langer C, Bullinger L, Reiter C, Slotta-Huspenina J, Schroeder S, Knorn AM, Kurutz J, Peschel C, Pagano M, Kuster B, Bassermann F.

Nat Cell Biol. 2013 Jan;15(1):72-81.


Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.

Grandin N, Corset L, Charbonneau M.

PLoS One. 2012;7(1):e30451. doi: 10.1371/journal.pone.0030451. Epub 2012 Jan 24.


Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.

Rao F, Cha J, Xu J, Xu R, Vandiver MS, Tyagi R, Tokhunts R, Koldobskiy MA, Fu C, Barrow R, Wu M, Fiedler D, Barrow JC, Snyder SH.

Mol Cell. 2014 Apr 10;54(1):119-32. doi: 10.1016/j.molcel.2014.02.020. Epub 2014 Mar 20.


Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.

Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula NR, Bhalla KN.

Mol Cancer Ther. 2011 Jul;10(7):1194-206. doi: 10.1158/1535-7163.MCT-11-0094. Epub 2011 May 12.


Cdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends.

Hirano Y, Sugimoto K.

Mol Biol Cell. 2007 Jun;18(6):2026-36. Epub 2007 Mar 21.

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