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Results: 1 to 20 of 193

1.

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia.

Tower C, Fu L, Gill R, Prichard M, Lesort M, Sztul E.

Neurobiol Dis. 2011 Jan;41(1):11-22. doi: 10.1016/j.nbd.2010.08.013. Epub 2010 Aug 20.

PMID:
20732421
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Transcriptional repression and cell death induced by nuclear aggregates of non-polyglutamine protein.

Fu L, Gao YS, Sztul E.

Neurobiol Dis. 2005 Dec;20(3):656-65. Epub 2005 Jun 16.

PMID:
15964198
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein.

Omi K, Hachiya NS, Tanaka M, Tokunaga K, Kaneko K.

Neurosci Lett. 2008 Jan 24;431(1):45-50. Epub 2007 Nov 17.

PMID:
18078716
[PubMed - indexed for MEDLINE]
4.

Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease.

Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4764-9.

PMID:
11296304
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.

Helmlinger D, Abou-Sleymane G, Yvert G, Rousseau S, Weber C, Trottier Y, Mandel JL, Devys D.

J Neurosci. 2004 Feb 25;24(8):1881-7.

PMID:
14985428
[PubMed - indexed for MEDLINE]
Free Article
6.

Protein aggregation and neurodegeneration: clues from a yeast model of Huntington's disease.

Bocharova N, Chave-Cox R, Sokolov S, Knorre D, Severin F.

Biochemistry (Mosc). 2009 Feb;74(2):231-4.

PMID:
19267681
[PubMed - indexed for MEDLINE]
Free Article
7.

Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin.

Miller SL, Scappini EL, O'Bryan J.

J Biol Chem. 2007 Mar 30;282(13):10096-103. Epub 2007 Feb 2.

PMID:
17276991
[PubMed - indexed for MEDLINE]
Free Article
8.

A huntingtin peptide inhibits polyQ-huntingtin associated defects.

Arribat Y, Bonneaud N, Talmat-Amar Y, Layalle S, Parmentier ML, Maschat F.

PLoS One. 2013 Jul 4;8(7):e68775. doi: 10.1371/journal.pone.0068775. Print 2013.

PMID:
23861941
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.

Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.

Somat Cell Mol Genet. 1998 Jul;24(4):217-33.

PMID:
10410676
[PubMed - indexed for MEDLINE]
10.

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.

Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.

J Biol Chem. 2003 Oct 17;278(42):41452-61. Epub 2003 Jul 29.

PMID:
12888569
[PubMed - indexed for MEDLINE]
Free Article
11.

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

Haacke A, Broadley SA, Boteva R, Tzvetkov N, Hartl FU, Breuer P.

Hum Mol Genet. 2006 Feb 15;15(4):555-68. Epub 2006 Jan 11.

PMID:
16407371
[PubMed - indexed for MEDLINE]
Free Article
12.

Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells.

Chun W, Lesort M, Tucholski J, Faber PW, MacDonald ME, Ross CA, Johnson GV.

Neurobiol Dis. 2001 Jun;8(3):391-404.

PMID:
11442349
[PubMed - indexed for MEDLINE]
13.

Evidence for a recruitment and sequestration mechanism in Huntington's disease.

Preisinger E, Jordan BM, Kazantsev A, Housman D.

Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1029-34.

PMID:
10434302
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

Krol HA, Krawczyk PM, Bosch KS, Aten JA, Hol EM, Reits EA.

PLoS One. 2008 Jan 30;3(1):e1503. doi: 10.1371/journal.pone.0001503.

PMID:
18231590
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin.

Wang H, Lim PJ, Yin C, Rieckher M, Vogel BE, Monteiro MJ.

Hum Mol Genet. 2006 Mar 15;15(6):1025-41. Epub 2006 Feb 6.

PMID:
16461334
[PubMed - indexed for MEDLINE]
Free Article
16.

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations.

Wanker EE.

Biol Chem. 2000 Sep-Oct;381(9-10):937-42. Review.

PMID:
11076024
[PubMed - indexed for MEDLINE]
17.

H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.

Wang HL, Hu SH, Chou AH, Wang SS, Weng YH, Yeh TH.

Neuropharmacology. 2013 Jul;70:1-11. doi: 10.1016/j.neuropharm.2013.01.006. Epub 2013 Jan 21.

PMID:
23347954
[PubMed - indexed for MEDLINE]
18.

Polyglutamine expansion mutation yields a pathological epitope linked to nucleation of protein aggregate: determinant of Huntington's disease onset.

Sugaya K, Matsubara S, Kagamihara Y, Kawata A, Hayashi H.

PLoS One. 2007 Jul 25;2(7):e635.

PMID:
17653262
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.

Poirier MA, Jiang H, Ross CA.

Hum Mol Genet. 2005 Mar 15;14(6):765-74. Epub 2005 Feb 2.

PMID:
15689354
[PubMed - indexed for MEDLINE]
Free Article
20.

Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis.

Prichard MN, Britt WJ, Daily SL, Hartline CB, Kern ER.

J Virol. 2005 Dec;79(24):15494-502.

PMID:
16306620
[PubMed - indexed for MEDLINE]
Free PMC Article

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