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Activation of specific apoptotic caspases with an engineered small-molecule-activated protease.

Gray DC, Mahrus S, Wells JA.

Cell. 2010 Aug 20;142(4):637-46. doi: 10.1016/j.cell.2010.07.014.


Inhibition of proteasome function induced apoptosis in gastric cancer.

Fan XM, Wong BC, Wang WP, Zhou XM, Cho CH, Yuen ST, Leung SY, Lin MC, Kung HF, Lam SK.

Int J Cancer. 2001 Aug 15;93(4):481-8.


Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.

Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T.

J Neurosci. 2000 Jan 1;20(1):259-65.


Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.

Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.

J Biol Chem. 2010 May 28;285(22):16632-42. doi: 10.1074/jbc.M109.095083. Epub 2010 Mar 22. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6838.


Caspase-7 mediated cleavage of proteasome subunits during apoptosis.

Jang M, Park BC, Lee AY, Na KS, Kang S, Bae KH, Myung PK, Chung BC, Cho S, Lee do H, Park SG.

Biochem Biophys Res Commun. 2007 Nov 16;363(2):388-94. Epub 2007 Sep 10.


Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.

Wejda M, Impens F, Takahashi N, Van Damme P, Gevaert K, Vandenabeele P.

J Biol Chem. 2012 Oct 5;287(41):33983-95. doi: 10.1074/jbc.M112.384552. Epub 2012 Jul 23.


Apoptosis induced in hepatoblastoma HepG2 cells by the proteasome inhibitor MG132 is associated with hydrogen peroxide production, expression of Bcl-XS and activation of caspase-3.

Emanuele S, Calvaruso G, Lauricella M, Giuliano M, Bellavia G, D'Anneo A, Vento R, Tesoriere G.

Int J Oncol. 2002 Oct;21(4):857-65.


An optimized activity-based probe for the study of caspase-6 activation.

Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.

Chem Biol. 2012 Mar 23;19(3):340-52. doi: 10.1016/j.chembiol.2011.12.021.


Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation.

Leverkus M, Sprick MR, Wachter T, Mengling T, Baumann B, Serfling E, Bröcker EB, Goebeler M, Neumann M, Walczak H.

Mol Cell Biol. 2003 Feb;23(3):777-90.


Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells.

Nagy K, Petak I, Imre G, Barna G, Gezane-Csorba M, Sebestyen A, Houghton JA, Mihalik R, Kopper L.

Anticancer Res. 2005 Sep-Oct;25(5):3321-6.


Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells.

Naujokat C, Sezer O, Zinke H, Leclere A, Hauptmann S, Possinger K.

Eur J Haematol. 2000 Oct;65(4):221-36.


The apoptotic effects and synergistic interaction of sodium butyrate and MG132 in human retinoblastoma Y79 cells.

Giuliano M, Lauricella M, Calvaruso G, Carabillò M, Emanuele S, Vento R, Tesoriere G.

Cancer Res. 1999 Nov 1;59(21):5586-95.


Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis.

Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K, Sasada M.

J Exp Med. 1998 Feb 16;187(4):587-600.


Inhibition of the ubiquitin-proteasome pathway activates stress kinases and induces apoptosis in renal cancer cells.

Ishizawa J, Yoshida S, Oya M, Mizuno R, Shinojima T, Marumo K, Murai M.

Int J Oncol. 2004 Sep;25(3):697-702.

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