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Items: 1 to 20 of 102


A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice.

Tichelaar JW, Yan Y, Tan Q, Wang Y, Estensen RD, Young MR, Colburn NH, Yin H, Goodin C, Anderson MW, You M.

Cancer Prev Res (Phila). 2010 Sep;3(9):1148-56. doi: 10.1158/1940-6207.CAPR-10-0023. Epub 2010 Aug 17.


Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation.

Dhar A, Hu J, Reeves R, Resar LM, Colburn NH.

Oncogene. 2004 May 27;23(25):4466-76.


Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis.

Matthews CP, Birkholz AM, Baker AR, Perella CM, Beck GR Jr, Young MR, Colburn NH.

Cancer Res. 2007 Mar 15;67(6):2430-8.


Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model.

Cooper SJ, MacGowan J, Ranger-Moore J, Young MR, Colburn NH, Bowden GT.

Mol Cancer Res. 2003 Sep;1(11):848-54.


Transcriptomic analysis by RNA-seq reveals AP-1 pathway as key regulator that green tea may rely on to inhibit lung tumorigenesis.

Pan J, Zhang Q, Xiong D, Vedell P, Yan Y, Jiang H, Cui P, Ding F, Tichelaar JW, Wang Y, Lubet RA, You M.

Mol Carcinog. 2014 Jan;53(1):19-29. doi: 10.1002/mc.21941. Epub 2012 Jul 31.


Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors.

Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH.

Cancer Prev Res (Phila). 2008 Jun;1(1):45-55. doi: 10.1158/1940-6207.CAPR-08-0034. Epub 2008 Mar 31.


A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes.

Dong Z, Crawford HC, Lavrovsky V, Taub D, Watts R, Matrisian LM, Colburn NH.

Mol Carcinog. 1997 Jul;19(3):204-12.


Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.

Young MR, Li JJ, Rincón M, Flavell RA, Sathyanarayana BK, Hunziker R, Colburn N.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9827-32.


Differential inhibition of UVB-induced AP-1 and NF-kappaB transactivation by components of the jun bZIP domain.

Cooper S, Ranger-Moore J, Bowden TG.

Mol Carcinog. 2005 Jun;43(2):108-16.


Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant-negative mutant.

Shimizu Y, Kinoshita I, Kikuchi J, Yamazaki K, Nishimura M, Birrer MJ, Dosaka-Akita H.

Br J Cancer. 2008 Mar 11;98(5):915-22. doi: 10.1038/sj.bjc.6604267. Epub 2008 Feb 19.


Overexpression of activating transcription factor-2 is required for tumor growth and progression in mouse skin tumors.

Papassava P, Gorgoulis VG, Papaevangeliou D, Vlahopoulos S, van Dam H, Zoumpourlis V.

Cancer Res. 2004 Dec 1;64(23):8573-84.


A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion.

Thompson EJ, MacGowan J, Young MR, Colburn N, Bowden GT.

Cancer Res. 2002 Jun 1;62(11):3044-7.


Hexavalent chromium Cr(VI) up-regulates COX-2 expression through an NFκB/c-Jun/AP-1-dependent pathway.

Zuo Z, Cai T, Li J, Zhang D, Yu Y, Huang C.

Environ Health Perspect. 2012 Apr;120(4):547-53. doi: 10.1289/ehp.1104179. Epub 2012 Jan 6.


Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.

Watts RG, Huang C, Young MR, Li JJ, Dong Z, Pennie WD, Colburn NH.

Oncogene. 1998 Dec 31;17(26):3493-8.


cFos is critical for MCF-7 breast cancer cell growth.

Lu C, Shen Q, DuPré E, Kim H, Hilsenbeck S, Brown PH.

Oncogene. 2005 Sep 29;24(43):6516-24.


Inhibition of AP-1 suppresses cervical cancer cell proliferation and is associated with p21 expression.

Maritz MF, van der Watt PJ, Holderness N, Birrer MJ, Leaner VD.

Biol Chem. 2011 May;392(5):439-48. doi: 10.1515/BC.2011.036. Epub 2011 Mar 22.


Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).

Grant S, Freemerman AJ, Birrer MJ, Martin HA, Turner AJ, Szabo E, Chelliah J, Jarvis WD.

Cell Growth Differ. 1996 May;7(5):603-13.

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