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Results: 1 to 20 of 98

1.

Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.

Li L, Smith A, Hagen TM, Frei B.

Ann N Y Acad Sci. 2010 Aug;1203:151-9. doi: 10.1111/j.1749-6632.2010.05555.x.

PMID:
20716298
[PubMed - indexed for MEDLINE]
2.

Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.

Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM.

FASEB J. 2001 Mar;15(3):700-6.

PMID:
11259388
[PubMed - indexed for MEDLINE]
Free Article
3.

R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM.

Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97. doi: 10.1152/ajpregu.00393.2011. Epub 2011 Nov 2.

PMID:
22049228
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.

Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB.

FASEB J. 1999 Feb;13(2):411-8.

PMID:
9973329
[PubMed - indexed for MEDLINE]
Free Article
5.

Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes.

Koçak G, Aktan F, Canbolat O, Ozoğul C, Elbeğ S, Yildizoglu-Ari N, Karasu C; ADIC Study Group--Antioxidants in Diabetes-Induced Complications.

Diabetes Nutr Metab. 2000 Dec;13(6):308-18.

PMID:
11232755
[PubMed - indexed for MEDLINE]
6.

Impact of α-lipoic acid on liver peroxisome proliferator-activated receptor-α, vascular remodeling, and oxidative stress in insulin-resistant rats.

El Midaoui A, Lungu C, Wang H, Wu L, Robillard C, Deblois D, Couture R.

Can J Physiol Pharmacol. 2011 Oct;89(10):743-51. doi: 10.1139/y11-072. Epub 2011 Sep 15.

PMID:
21919742
[PubMed - indexed for MEDLINE]
7.

Effect of aging on aortic expression of the vascular cell adhesion molecule-1 and atherosclerosis in murine models of atherosclerosis.

Merat S, Fruebis J, Sutphin M, Silvestre M, Reaven PD.

J Gerontol A Biol Sci Med Sci. 2000 Feb;55(2):B85-94.

PMID:
10737683
[PubMed - indexed for MEDLINE]
8.

Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.

Bitar MS, Ayed AK, Abdel-Halim SM, Isenovic ER, Al-Mulla F.

Life Sci. 2010 Jun 5;86(23-24):844-53. doi: 10.1016/j.lfs.2010.03.019. Epub 2010 Apr 11.

PMID:
20388520
[PubMed - indexed for MEDLINE]
9.

Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice.

Harrison CB, Drummond GR, Sobey CG, Selemidis S.

Clin Exp Pharmacol Physiol. 2010 Apr;37(4):429-34. doi: 10.1111/j.1440-1681.2009.05317.x. Epub 2009 Oct 16.

PMID:
19843095
[PubMed - indexed for MEDLINE]
10.

Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition.

Wind S, Beuerlein K, Armitage ME, Taye A, Kumar AH, Janowitz D, Neff C, Shah AM, Wingler K, Schmidt HH.

Hypertension. 2010 Sep;56(3):490-7. doi: 10.1161/HYPERTENSIONAHA.109.149187. Epub 2010 Jul 6.

PMID:
20606112
[PubMed - indexed for MEDLINE]
Free Article
11.

Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress.

Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5. Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184.

PMID:
11854487
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Antioxidant supplementation normalizes elevated protein kinase C activity in the proximal tubules of old rats.

Asghar M, Lokhandwala MF.

Exp Biol Med (Maywood). 2004 Mar;229(3):270-5.

PMID:
14988520
[PubMed - indexed for MEDLINE]
13.
14.

Regression of atherosclerosis by amlodipine via anti-inflammatory and anti-oxidative stress actions.

Yoshii T, Iwai M, Li Z, Chen R, Ide A, Fukunaga S, Oshita A, Mogi M, Higaki J, Horiuchi M.

Hypertens Res. 2006 Jun;29(6):457-66.

PMID:
16940709
[PubMed - indexed for MEDLINE]
15.

Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid.

El Midaoui A, de Champlain J.

Hypertension. 2002 Feb;39(2):303-7.

PMID:
11847202
[PubMed - indexed for MEDLINE]
Free Article
16.

Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.

Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN.

FASEB J. 1998 Sep;12(12):1183-9.

PMID:
9737721
[PubMed - indexed for MEDLINE]
Free Article
17.

Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.

Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J.

J Neurosci Res. 2006 Aug 15;84(3):647-54.

PMID:
16710848
[PubMed - indexed for MEDLINE]
18.

Rice bran enzymatic extract restores endothelial function and vascular contractility in obese rats by reducing vascular inflammation and oxidative stress.

Justo ML, Candiracci M, Dantas AP, de Sotomayor MA, Parrado J, Vila E, Herrera MD, Rodriguez-Rodriguez R.

J Nutr Biochem. 2013 Aug;24(8):1453-61. doi: 10.1016/j.jnutbio.2012.12.004. Epub 2013 Mar 1.

PMID:
23465593
[PubMed - indexed for MEDLINE]
19.

Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain.

Thakurta IG, Chattopadhyay M, Ghosh A, Chakrabarti S.

Biogerontology. 2012 Oct;13(5):479-88. doi: 10.1007/s10522-012-9392-5. Epub 2012 Aug 1.

PMID:
22851277
[PubMed - indexed for MEDLINE]
20.

Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta.

Zanetti M, Gortan Cappellari G, Burekovic I, Barazzoni R, Stebel M, Guarnieri G.

Exp Gerontol. 2010 Nov;45(11):848-55. doi: 10.1016/j.exger.2010.07.002. Epub 2010 Jul 14.

PMID:
20637278
[PubMed - indexed for MEDLINE]
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