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Items: 1 to 20 of 124


Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity.

Guo X, Ward MD, Tiedebohl JB, Oden YM, Nyalwidhe JO, Semmes OJ.

J Biol Chem. 2010 Oct 22;285(43):33348-57. doi: 10.1074/jbc.M110.149609. Epub 2010 Aug 16.


Human T-cell leukemia virus type 1 Tax oncoprotein prevents DNA damage-induced chromatin egress of hyperphosphorylated Chk2.

Gupta SK, Guo X, Durkin SS, Fryrear KF, Ward MD, Semmes OJ.

J Biol Chem. 2007 Oct 5;282(40):29431-40. Epub 2007 Aug 13.


Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.

Wu X, Chen J.

J Biol Chem. 2003 Sep 19;278(38):36163-8. Epub 2003 Jul 9.


Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

Yoda A, Xu XZ, Onishi N, Toyoshima K, Fujimoto H, Kato N, Oishi I, Kondo T, Minami Y.

J Biol Chem. 2006 Aug 25;281(34):24847-62. Epub 2006 Jun 23.


DNA damage regulates Chk2 association with chromatin.

Li J, Stern DF.

J Biol Chem. 2005 Nov 11;280(45):37948-56. Epub 2005 Sep 8.


Chk2 activation and phosphorylation-dependent oligomerization.

Xu X, Tsvetkov LM, Stern DF.

Mol Cell Biol. 2002 Jun;22(12):4419-32.


Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.

Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D.

Mol Cancer Ther. 2007 Mar;6(3):935-44.


Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.


Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.

Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H.

Mol Cell Biol. 2008 Oct;28(19):5874-85. doi: 10.1128/MCB.00821-08. Epub 2008 Jul 21.


DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.

Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S, Delia D.

Mol Cell Biol. 2006 Nov;26(21):7832-45. Epub 2006 Aug 28.


MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J.

Nature. 2003 Feb 27;421(6926):957-61.


Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C.

J Biol Chem. 2007 Oct 12;282(41):30311-21. Epub 2007 Aug 21.


Regulation of eukaryotic-like protein kinase activity of DspA from Myxococcus xanthus by autophosphorylation.

Okamoto R, Takegawa K, Kimura Y.

J Biochem. 2014 Feb;155(2):99-106. doi: 10.1093/jb/mvt101. Epub 2013 Nov 5.


Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.

Schwarz JK, Lovly CM, Piwnica-Worms H.

Mol Cancer Res. 2003 Jun;1(8):598-609.


Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.

Luo H, Li Y, Mu JJ, Zhang J, Tonaka T, Hamamori Y, Jung SY, Wang Y, Qin J.

J Biol Chem. 2008 Jul 11;283(28):19176-83. doi: 10.1074/jbc.M802299200. Epub 2008 Apr 28.


The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

Tosti E, Waldbaum L, Warshaw G, Gross EA, Ruggieri R.

J Biol Chem. 2004 Nov 12;279(46):47652-60. Epub 2004 Sep 1.


Chk2 activation dependence on Nbs1 after DNA damage.

Buscemi G, Savio C, Zannini L, Miccichè F, Masnada D, Nakanishi M, Tauchi H, Komatsu K, Mizutani S, Khanna K, Chen P, Concannon P, Chessa L, Delia D.

Mol Cell Biol. 2001 Aug;21(15):5214-22.


Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.

Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR.

Biochem J. 2002 Dec 1;368(Pt 2):507-16.

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