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Results: 1 to 20 of 106

1.

Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.

Sarkari F, La Delfa A, Arrowsmith CH, Frappier L, Sheng Y, Saridakis V.

J Mol Biol. 2010 Oct 8;402(5):825-37. doi: 10.1016/j.jmb.2010.08.017. Epub 2010 Aug 14.

PMID:
20713061
[PubMed - indexed for MEDLINE]
2.

Molecular recognition of p53 and MDM2 by USP7/HAUSP.

Sheng Y, Saridakis V, Sarkari F, Duan S, Wu T, Arrowsmith CH, Frappier L.

Nat Struct Mol Biol. 2006 Mar;13(3):285-91. Epub 2006 Feb 12.

PMID:
16474402
[PubMed - indexed for MEDLINE]
3.

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.

Kallen J, Goepfert A, Blechschmidt A, Izaac A, Geiser M, Tavares G, Ramage P, Furet P, Masuya K, Lisztwan J.

J Biol Chem. 2009 Mar 27;284(13):8812-21. doi: 10.1074/jbc.M809096200. Epub 2009 Jan 19.

PMID:
19153082
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.

Meulmeester E, Maurice MM, Boutell C, Teunisse AF, Ovaa H, Abraham TE, Dirks RW, Jochemsen AG.

Mol Cell. 2005 May 27;18(5):565-76. Erratum in: Mol Cell. 2005 Jul 1;19(1):143-4.

PMID:
15916963
[PubMed - indexed for MEDLINE]
Free Article
5.

Defining the molecular basis of Arf and Hdm2 interactions.

Bothner B, Lewis WS, DiGiammarino EL, Weber JD, Bothner SJ, Kriwacki RW.

J Mol Biol. 2001 Nov 23;314(2):263-77.

PMID:
11718560
[PubMed - indexed for MEDLINE]
6.

C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site.

Ma J, Martin JD, Xue Y, Lor LA, Kennedy-Wilson KM, Sinnamon RH, Ho TF, Zhang G, Schwartz B, Tummino PJ, Lai Z.

Arch Biochem Biophys. 2010 Nov 15;503(2):207-12. doi: 10.1016/j.abb.2010.08.020. Epub 2010 Sep 15.

PMID:
20816748
[PubMed - indexed for MEDLINE]
7.

c-Abl phosphorylates Hdmx and regulates its interaction with p53.

Zuckerman V, Lenos K, Popowicz GM, Silberman I, Grossman T, Marine JC, Holak TA, Jochemsen AG, Haupt Y.

J Biol Chem. 2009 Feb 6;284(6):4031-9. doi: 10.1074/jbc.M809211200. Epub 2008 Dec 15.

PMID:
19075013
[PubMed - indexed for MEDLINE]
Free Article
8.

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12009-14. Epub 2003 Sep 24.

PMID:
14507994
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.

Kostic M, Matt T, Martinez-Yamout MA, Dyson HJ, Wright PE.

J Mol Biol. 2006 Oct 20;363(2):433-50. Epub 2006 Aug 14.

PMID:
16965791
[PubMed - indexed for MEDLINE]
10.

Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.

Datta S, Bucks ME, Koley D, Lim PX, Savinov SN.

Bioorg Med Chem. 2010 Aug 15;18(16):6099-108. doi: 10.1016/j.bmc.2010.06.053. Epub 2010 Jun 22.

PMID:
20638853
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation.

Migliorini D, Danovi D, Colombo E, Carbone R, Pelicci PG, Marine JC.

J Biol Chem. 2002 Mar 1;277(9):7318-23. Epub 2001 Dec 13.

PMID:
11744695
[PubMed - indexed for MEDLINE]
Free Article
12.

Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T, Zhang RG, Liao J, Lee W, Edwards AM, Arrowsmith CH, Frappier L.

Mol Cell. 2005 Apr 1;18(1):25-36.

PMID:
15808506
[PubMed - indexed for MEDLINE]
Free Article
13.

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD.

Cancer Cell. 2010 Nov 16;18(5):411-22. doi: 10.1016/j.ccr.2010.10.024.

PMID:
21075307
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.

Giglio S, Mancini F, Gentiletti F, Sparaco G, Felicioni L, Barassi F, Martella C, Prodosmo A, Iacovelli S, Buttitta F, Farsetti A, Soddu S, Marchetti A, Sacchi A, Pontecorvi A, Moretti F.

Cancer Res. 2005 Nov 1;65(21):9687-94.

PMID:
16266988
[PubMed - indexed for MEDLINE]
Free Article
15.

Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.

Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L.

J Biol Chem. 2003 Nov 28;278(48):47753-61. Epub 2003 Sep 23.

PMID:
14506283
[PubMed - indexed for MEDLINE]
Free Article
16.

Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

Hu M, Gu L, Li M, Jeffrey PD, Gu W, Shi Y.

PLoS Biol. 2006 Feb;4(2):e27. Epub 2006 Jan 17.

PMID:
16402859
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2.

de Graaf P, Little NA, Ramos YF, Meulmeester E, Letteboer SJ, Jochemsen AG.

J Biol Chem. 2003 Oct 3;278(40):38315-24. Epub 2003 Jul 21.

PMID:
12874296
[PubMed - indexed for MEDLINE]
Free Article
18.

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.

Wilder PT, Lin J, Bair CL, Charpentier TH, Yang D, Liriano M, Varney KM, Lee A, Oppenheim AB, Adhya S, Carrier F, Weber DJ.

Biochim Biophys Acta. 2006 Nov;1763(11):1284-97. Epub 2006 Aug 25.

PMID:
17010455
[PubMed - indexed for MEDLINE]
Free Article
19.

Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization.

Fernández-Montalván A, Bouwmeester T, Joberty G, Mader R, Mahnke M, Pierrat B, Schlaeppi JM, Worpenberg S, Gerhartz B.

FEBS J. 2007 Aug;274(16):4256-70. Epub 2007 Jul 25.

PMID:
17651432
[PubMed - indexed for MEDLINE]
20.

Beta-peptides with improved affinity for hDM2 and hDMX.

Harker EA, Daniels DS, Guarracino DA, Schepartz A.

Bioorg Med Chem. 2009 Mar 1;17(5):2038-46. doi: 10.1016/j.bmc.2009.01.039. Epub 2009 Jan 23.

PMID:
19211253
[PubMed - indexed for MEDLINE]
Free PMC Article
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