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Results: 1 to 20 of 178

1.

β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation.

Gregg CJ, Steppan J, Gonzalez DR, Champion HC, Phan AC, Nyhan D, Shoukas AA, Hare JM, Barouch LA, Berkowitz DE.

Anesth Analg. 2010 Oct;111(4):870-7. doi: 10.1213/ANE.0b013e3181ee8312. Epub 2010 Aug 12.

PMID:
20705779
[PubMed - indexed for MEDLINE]
2.

Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90. Epub 2004 Nov 11.

PMID:
15539636
[PubMed - indexed for MEDLINE]
Free Article
3.

Effects of milrinone on contractility and cyclic adenosine monophosphate production induced by beta1- and beta2-adrenergic receptor activation in human myocardium.

Carceles MD, Fuentes T, Aroca V, Lopez J, Hernández J.

Clin Ther. 2007 Aug;29(8):1718-24.

PMID:
17919552
[PubMed - indexed for MEDLINE]
4.

Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation.

Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP.

Circ Res. 2002 Jul 12;91(1):46-53.

PMID:
12114321
[PubMed - indexed for MEDLINE]
Free Article
5.

PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes.

Kerfant BG, Zhao D, Lorenzen-Schmidt I, Wilson LS, Cai S, Chen SR, Maurice DH, Backx PH.

Circ Res. 2007 Aug 17;101(4):400-8. Epub 2007 Jul 5.

PMID:
17615371
[PubMed - indexed for MEDLINE]
Free Article
6.

Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling.

Nikolaev VO, Bünemann M, Schmitteckert E, Lohse MJ, Engelhardt S.

Circ Res. 2006 Nov 10;99(10):1084-91. Epub 2006 Oct 12.

PMID:
17038640
[PubMed - indexed for MEDLINE]
Free Article
7.

Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.

Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G.

Circ Res. 2008 May 9;102(9):1091-100. doi: 10.1161/CIRCRESAHA.107.167817. Epub 2008 Mar 27.

PMID:
18369156
[PubMed - indexed for MEDLINE]
Free Article
8.

Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor.

Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP.

J Biol Chem. 2000 Jul 14;275(28):21773-9.

PMID:
10787424
[PubMed - indexed for MEDLINE]
Free Article
9.

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi.

Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5. Epub 2003 Jan 27.

PMID:
12552097
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Phosphodiesterase 4 and phosphatase 2A differentially regulate cAMP/protein kinase a signaling for cardiac myocyte contraction under stimulation of beta1 adrenergic receptor.

De Arcangelis V, Soto D, Xiang Y.

Mol Pharmacol. 2008 Nov;74(5):1453-62. doi: 10.1124/mol.108.049718. Epub 2008 Aug 14.

PMID:
18703669
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.

Takimoto E, Belardi D, Tocchetti CG, Vahebi S, Cormaci G, Ketner EA, Moens AL, Champion HC, Kass DA.

Circulation. 2007 Apr 24;115(16):2159-67. Epub 2007 Apr 9. Erratum in: Circulation. 2007 May 22;115(20):e536.

PMID:
17420342
[PubMed - indexed for MEDLINE]
Free Article
12.

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes.

Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA, Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG.

Circ Res. 1999 Jan 8-22;84(1):43-52.

PMID:
9915773
[PubMed - indexed for MEDLINE]
Free Article
13.

Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes.

Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK.

PLoS One. 2012;7(8):e42658. doi: 10.1371/journal.pone.0042658. Epub 2012 Aug 9.

PMID:
22912718
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Enhanced cardiac L-type calcium current response to beta2-adrenergic stimulation in heart failure.

Zhang ZS, Cheng HJ, Ukai T, Tachibana H, Cheng CP.

J Pharmacol Exp Ther. 2001 Jul;298(1):188-96.

PMID:
11408541
[PubMed - indexed for MEDLINE]
Free Article
15.

A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.

Yano N, Ianus V, Zhao TC, Tseng A, Padbury JF, Tseng YT.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H385-93. Epub 2007 Mar 16.

PMID:
17369456
[PubMed - indexed for MEDLINE]
Free Article
16.

Localized cAMP-dependent signaling mediates beta 2-adrenergic modulation of cardiac excitation-contraction coupling.

Zhou YY, Cheng H, Bogdanov KY, Hohl C, Altschuld R, Lakatta EG, Xiao RP.

Am J Physiol. 1997 Sep;273(3 Pt 2):H1611-8.

PMID:
9321856
[PubMed - indexed for MEDLINE]
17.

Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.

Duarte T, Menezes-Rodrigues FS, Godinho RO.

J Pharmacol Exp Ther. 2012 Jun;341(3):820-8. doi: 10.1124/jpet.112.192997. Epub 2012 Mar 21.

PMID:
22438472
[PubMed - indexed for MEDLINE]
Free Article
18.

Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.

Osadchii OE.

Cardiovasc Drugs Ther. 2007 Jun;21(3):171-94. Epub 2007 Mar 21. Review.

PMID:
17373584
[PubMed - indexed for MEDLINE]
19.

Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes.

Jurevicius J, Skeberdis VA, Fischmeister R.

J Physiol. 2003 Aug 15;551(Pt 1):239-52. Epub 2003 Jun 18.

PMID:
12815180
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.

Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B.

Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):909-14. Epub 2005 Jan 11.

PMID:
15644445
[PubMed - indexed for MEDLINE]
Free PMC Article

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