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Items: 1 to 20 of 96

1.

[17(20)E]- and [17(20)Z]-pregna-5,17(20)-dien-21-oylamides. Facile synthesis and primary evaluation for cancer cells proliferation.

Stulov SV, Zavialova MG, Mehtiev AR, Novikov RA, Tkachev YV, Timofeev VP, Misharin AY.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5495-8. doi: 10.1016/j.bmcl.2010.07.075. Epub 2010 Jul 21.

PMID:
20702093
2.

Synthesis of 21-nitrogen substituted pregna-5,17(20)-dienes from pregnenolone.

Stulov SV, Tkachev YV, Novikov RA, Zavialova MG, Timofeev VP, Misharin AY.

Steroids. 2012 Jan;77(1-2):77-84. doi: 10.1016/j.steroids.2011.10.007. Epub 2011 Oct 26.

PMID:
22064217
3.

Synthesis of 3beta, 7alpha, 11alpha-trihydroxy-pregn-21-benzylidene-5-en-20-one derivatives and their cytotoxic activities.

Shan LH, Liu HM, Huang KX, Dai GF, Cao C, Dong RJ.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6637-9. doi: 10.1016/j.bmcl.2009.10.019. Epub 2009 Oct 14.

PMID:
19864129
4.

[Antitumor activity of the new gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one].

Sergeev PV, Semeĭkin AV, Smirnova ZS, Rzheznikov VM, Grinenko GS, Fedosov AV, Fedotcheva TA, Shimanovskiĭ NL.

Eksp Klin Farmakol. 2004 Jul-Aug;67(4):54-6. Russian.

PMID:
15500049
5.

Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents.

Banday AH, Mir BP, Lone IH, Suri KA, Kumar HM.

Steroids. 2010 Dec;75(12):805-9. doi: 10.1016/j.steroids.2010.02.014. Epub 2010 Mar 4.

PMID:
20206644
6.

Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.

Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman D Jr, Farquhar R, Guo Z, Qiu Y, Brodie AM.

J Med Chem. 2005 Apr 21;48(8):2972-84.

PMID:
15828836
7.

Design and synthesis of 21-alkynylaryl pregnenolone derivatives and evaluation of their anticancer activity.

Szalóki G, Pantzou A, Prousis KC, Mavrofrydi O, Papazafiri P, Calogeropoulou T.

Bioorg Med Chem. 2014 Dec 15;22(24):6980-8. doi: 10.1016/j.bmc.2014.10.012. Epub 2014 Oct 25.

PMID:
25456391
8.

Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives.

Vanquelef E, Hélesbeux JJ, Duval O, Debiton E, Barthomeuf C, Jarry C, Forfar I, Richomme P.

J Enzyme Inhib Med Chem. 2007 Oct;22(5):647-54.

PMID:
18035833
9.

Pregna-5,17(20)-dien-21-oyl amides affecting sterol and triglyceride biosynthesis in Hep G2 cells.

Stulov SV, Mankevich OV, Dugin NO, Novikov RA, Timofeev VP, Misharin AY.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2014-8. doi: 10.1016/j.bmcl.2013.02.026. Epub 2013 Feb 13.

PMID:
23466231
10.

Synthesis, structure elucidation and antitumour activity of N-substituted amides of 3-(3-ethylthio-1,2,4-triazol-5-yl)propenoic acid.

Pachuta-Stec A, Rzymowska J, Mazur L, Mendyk E, Pitucha M, Rzaczyńska Z.

Eur J Med Chem. 2009 Sep;44(9):3788-93. doi: 10.1016/j.ejmech.2009.04.034. Epub 2009 May 4.

PMID:
19482385
11.

Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells.

Lee CJ, Wilson L, Jordan MA, Nguyen V, Tang J, Smiyun G.

Phytother Res. 2010 Jan;24 Suppl 1:S15-9. doi: 10.1002/ptr.2856. Erratum in: Phytother Res. 2010 Apr;24(4):632.

PMID:
19548283
12.

Induction of apoptosis and inhibition of prostate and breast cancer growth by BGP-15, a new calcipotriene-derived vitamin D3 analog.

Berkovich L, Ben-Shabat S, Sintov AC.

Anticancer Drugs. 2010 Jul;21(6):609-18. doi: 10.1097/CAD.0b013e328337f3e9.

PMID:
20335794
13.

Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.

Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, Jänne OA, Visakorpi T.

Cancer Res. 2009 Oct 15;69(20):8141-9. doi: 10.1158/0008-5472.CAN-09-0919. Epub 2009 Oct 6.

14.
15.

2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.

Dettmann S, Szymanowitz K, Wellner A, Schiedel A, Müller CE, Gust R.

Bioorg Med Chem. 2010 Jul 15;18(14):4905-16. doi: 10.1016/j.bmc.2010.06.016. Epub 2010 Jun 9.

PMID:
20598555
16.

Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.

Zhang P, Sun X, Xu B, Bijian K, Wan S, Li G, Alaoui-Jamali M, Jiang T.

Eur J Med Chem. 2011 Dec;46(12):6089-97. doi: 10.1016/j.ejmech.2011.10.036. Epub 2011 Oct 25.

PMID:
22047643
19.

P450-dependent enzymes as targets for prostate cancer therapy.

De Coster R, Wouters W, Bruynseels J.

J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):133-43. Review.

PMID:
8603034
20.

Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells.

Tsui KH, Feng TH, Lin CM, Chang PL, Juang HH.

J Androl. 2008 Nov-Dec;29(6):661-8. doi: 10.2164/jandrol.108.004911. Epub 2008 Jul 31.

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