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Results: 1 to 20 of 117

1.

The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.

Improgo MR, Scofield MD, Tapper AR, Gardner PD.

Prog Neurobiol. 2010 Oct;92(2):212-26. doi: 10.1016/j.pneurobio.2010.05.003. Epub 2010 Jun 4. Review.

PMID:
20685379
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Molecular mechanisms underlying behaviors related to nicotine addiction.

Picciotto MR, Kenny PJ.

Cold Spring Harb Perspect Med. 2013 Jan 1;3(1):a012112. doi: 10.1101/cshperspect.a012112. Review.

PMID:
23143843
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.

Improgo MR, Schlichting NA, Cortes RY, Zhao-Shea R, Tapper AR, Gardner PD.

Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.

PMID:
20124469
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The CHRNA5-A3-B4 gene cluster in nicotine addiction.

Berrettini WH, Doyle GA.

Mol Psychiatry. 2012 Sep;17(9):856-66. doi: 10.1038/mp.2011.122. Epub 2011 Oct 4. Review.

PMID:
21968931
[PubMed - indexed for MEDLINE]
5.

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.

Li MD, Xu Q, Lou XY, Payne TJ, Niu T, Ma JZ.

Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):745-56. doi: 10.1002/ajmg.b.31043.

PMID:
19859904
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

From smoking to lung cancer: the CHRNA5/A3/B4 connection.

Improgo MR, Scofield MD, Tapper AR, Gardner PD.

Oncogene. 2010 Sep 2;29(35):4874-84. doi: 10.1038/onc.2010.256. Epub 2010 Jun 28. Review.

PMID:
20581870
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects.

Gallego X, Molas S, Amador-Arjona A, Marks MJ, Robles N, Murtra P, Armengol L, Fernández-Montes RD, Gratacòs M, Pumarola M, Cabrera R, Maldonado R, Sabrià J, Estivill X, Dierssen M.

Amino Acids. 2012 Aug;43(2):897-909. doi: 10.1007/s00726-011-1149-y. Epub 2011 Nov 19.

PMID:
22101982
[PubMed - indexed for MEDLINE]
8.

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions.

Greenbaum L, Lerer B.

Mol Psychiatry. 2009 Oct;14(10):912-45. doi: 10.1038/mp.2009.59. Epub 2009 Jun 30. Review.

PMID:
19564872
[PubMed - indexed for MEDLINE]
9.

A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF.

PLoS Genet. 2008 Jul 11;4(7):e1000125. doi: 10.1371/journal.pgen.1000125.

PMID:
18618000
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.

Stokes C, Papke RL.

Neuropharmacology. 2012 Sep;63(4):538-46. doi: 10.1016/j.neuropharm.2012.04.035. Epub 2012 May 11.

PMID:
22580377
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA.

Genet Epidemiol. 2013 Dec;37(8):846-59. doi: 10.1002/gepi.21760. Epub 2013 Nov 1.

PMID:
24186853
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Is susceptibility locus for lung cancer in the 15q25 nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 associated with risk of gastric cancer?

Wu H, Wang Y, Wang S, Jiang M, Wang C, Fu W, Hu L.

Med Oncol. 2013;30(2):576. doi: 10.1007/s12032-013-0576-x. Epub 2013 Apr 11.

PMID:
23576140
[PubMed - indexed for MEDLINE]
13.

Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.

Sarginson JE, Killen JD, Lazzeroni LC, Fortmann SP, Ryan HS, Schatzberg AF, Murphy GM Jr.

Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):275-84. doi: 10.1002/ajmg.b.31155. Epub 2011 Jan 25.

PMID:
21268243
[PubMed - indexed for MEDLINE]
14.

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.

Spitz MR, Amos CI, Dong Q, Lin J, Wu X.

J Natl Cancer Inst. 2008 Nov 5;100(21):1552-6. doi: 10.1093/jnci/djn363. Epub 2008 Oct 28.

PMID:
18957677
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.

Chen X, Chen J, Williamson VS, An SS, Hettema JM, Aggen SH, Neale MC, Kendler KS.

Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):926-33. doi: 10.1002/ajmg.b.30919.

PMID:
19132693
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes.

Chen LS, Xian H, Grucza RA, Saccone NL, Wang JC, Johnson EO, Breslau N, Hatsukami D, Bierut LJ.

Drug Alcohol Depend. 2012 Jun;123 Suppl 1:S42-51. doi: 10.1016/j.drugalcdep.2012.01.014. Epub 2012 Feb 13.

PMID:
22336398
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.

Bierut LJ.

Trends Pharmacol Sci. 2010 Jan;31(1):46-51. doi: 10.1016/j.tips.2009.10.004. Epub 2009 Nov 5. Review.

PMID:
19896728
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)₂α5 AChR function.

Kuryatov A, Berrettini W, Lindstrom J.

Mol Pharmacol. 2011 Jan;79(1):119-25. doi: 10.1124/mol.110.066357. Epub 2010 Sep 29.

PMID:
20881005
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.

Nees F, Witt SH, Lourdusamy A, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Frank J, Gallinat J, Garavan H, Heinz A, Ittermann B, Loth E, Mann K, Artiges E, Paus T, Pausova Z, Smolka MN, Struve M, Schumann G, Rietschel M, Flor H; IMAGEN consortium.

Neuropsychopharmacology. 2013 Oct;38(11):2081-9. doi: 10.1038/npp.2013.131. Epub 2013 May 21.

PMID:
23689675
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor.

Marotta CB, Dilworth CN, Lester HA, Dougherty DA.

Neuropharmacology. 2014 Feb;77:342-9. doi: 10.1016/j.neuropharm.2013.09.028. Epub 2013 Oct 18.

PMID:
24144909
[PubMed - indexed for MEDLINE]

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