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Items: 1 to 20 of 203

1.

IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.

Chapuis N, Park S, Leotoing L, Tamburini J, Verdier F, Bardet V, Green AS, Willems L, Agou F, Ifrah N, Dreyfus F, Bismuth G, Baud V, Lacombe C, Mayeux P, Bouscary D.

Blood. 2010 Nov 18;116(20):4240-50. doi: 10.1182/blood-2009-12-260711. Epub 2010 Jul 29.

2.

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a.

Buontempo F, Chiarini F, Bressanin D, Tabellini G, Melchionda F, Pession A, Fini M, Neri LM, McCubrey JA, Martelli AM.

Cell Cycle. 2012 Jul 1;11(13):2467-75. doi: 10.4161/cc.20859. Epub 2012 Jul 1.

PMID:
22713244
3.

Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.

Clavel S, Siffroi-Fernandez S, Coldefy AS, Boulukos K, Pisani DF, Dérijard B.

Mol Cell Biol. 2010 Jan;30(2):470-80. doi: 10.1128/MCB.00666-09. Epub 2009 Nov 16.

4.

Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M.

Cancer Res. 2006 Apr 1;66(7):3737-46.

5.

FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells.

Fang L, Wang H, Zhou L, Yu D.

Toxicol Appl Pharmacol. 2011 Feb 15;251(1):8-15. doi: 10.1016/j.taap.2010.11.007. Epub 2010 Nov 16.

PMID:
21092744
6.

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia.

Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A.

Nature. 2010 Feb 4;463(7281):676-80. doi: 10.1038/nature08734.

PMID:
20130650
7.

Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening.

Zanella F, Rosado A, García B, Carnero A, Link W.

Chembiochem. 2008 Sep 22;9(14):2229-37. doi: 10.1002/cbic.200800255.

PMID:
18756565
8.

FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity.

Sunayama J, Sato A, Matsuda K, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C.

Stem Cells. 2011 Sep;29(9):1327-37. doi: 10.1002/stem.696.

9.

Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions.

Walter PL, Kampkötter A, Eckers A, Barthel A, Schmoll D, Sies H, Klotz LO.

Arch Biochem Biophys. 2006 Oct 15;454(2):107-13. Epub 2006 Aug 30.

PMID:
16973122
10.
11.

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB.

Oncogene. 2007 Feb 22;26(8):1201-12. Epub 2006 Aug 21.

PMID:
16924232
12.

AEE788 is a vascular endothelial growth factor receptor tyrosine kinase inhibitor with antiproliferative and proapoptotic effects in acute myeloid leukemia.

Barbarroja N, Torres LA, Rodriguez-Ariza A, Valverde-Estepa A, Lopez-Sanchez LM, Ruiz-Limon P, Perez-Sanchez C, Carretero RM, Velasco F, López-Pedrera C.

Exp Hematol. 2010 Aug;38(8):641-52. doi: 10.1016/j.exphem.2010.03.017. Epub 2010 Apr 7.

PMID:
20380868
13.

A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation.

Wang X, Chen WR, Xing D.

J Cell Physiol. 2012 Mar;227(3):1168-78. doi: 10.1002/jcp.22839.

PMID:
21604264
15.

Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways.

Zhang T, Yang D, Fan Y, Xie P, Li H.

Apoptosis. 2009 Oct;14(10):1245-54. doi: 10.1007/s10495-009-0391-1.

PMID:
19669889
16.

Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.

Eur J Pharmacol. 2007 Jun 1;563(1-3):49-60. Epub 2007 Feb 8.

PMID:
17341418
17.

Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.

Hartman AD, Wilson-Weekes A, Suvannasankha A, Burgess GS, Phillips CA, Hincher KJ, Cripe LD, Boswell HS.

Exp Hematol. 2006 Oct;34(10):1360-76.

PMID:
16982329
18.

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC.

Cell. 2004 Apr 16;117(2):225-37. Erratum in: Cell. 2007 Jun 29;129(7):1427-8.

19.
20.

Phosphorylation of FOXO3a by PI3K/Akt pathway in HK-2 renal proximal tubular epithelial cells exposed to cadmium.

Fujiki K, Inamura H, Matsuoka M.

Arch Toxicol. 2013 Dec;87(12):2119-27. doi: 10.1007/s00204-013-1077-6. Epub 2013 May 15.

PMID:
23673518
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