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Results: 1 to 20 of 294

1.

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

Tsai KJ, Yang CH, Fang YH, Cho KH, Chien WL, Wang WT, Wu TW, Lin CP, Fu WM, Shen CK.

J Exp Med. 2010 Aug 2;207(8):1661-73. doi: 10.1084/jem.20092164. Epub 2010 Jul 26.

PMID:
20660618
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments.

Swarup V, Phaneuf D, Bareil C, Robertson J, Rouleau GA, Kriz J, Julien JP.

Brain. 2011 Sep;134(Pt 9):2610-26. doi: 10.1093/brain/awr159. Epub 2011 Jul 13.

PMID:
21752789
[PubMed - indexed for MEDLINE]
Free Article
3.

The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients.

Collins M, Riascos D, Kovalik T, An J, Krupa K, Krupa K, Hood BL, Conrads TP, Renton AE, Traynor BJ, Bowser R.

Acta Neuropathol. 2012 Nov;124(5):717-32. doi: 10.1007/s00401-012-1045-x. Epub 2012 Sep 21.

PMID:
22993125
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.

Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18809-14. doi: 10.1073/pnas.0908767106. Epub 2009 Oct 15.

PMID:
19833869
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.

Al-Sarraj S, King A, Troakes C, Smith B, Maekawa S, Bodi I, Rogelj B, Al-Chalabi A, Hortobágyi T, Shaw CE.

Acta Neuropathol. 2011 Dec;122(6):691-702. doi: 10.1007/s00401-011-0911-2. Epub 2011 Nov 19.

PMID:
22101323
[PubMed - indexed for MEDLINE]
6.

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM.

J Clin Invest. 2011 Feb;121(2):726-38. doi: 10.1172/JCI44867. Epub 2011 Jan 4.

PMID:
21206091
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.

Nishihira Y, Tan CF, Onodera O, Toyoshima Y, Yamada M, Morita T, Nishizawa M, Kakita A, Takahashi H.

Acta Neuropathol. 2008 Aug;116(2):169-82. doi: 10.1007/s00401-008-0385-z. Epub 2008 May 15.

PMID:
18481073
[PubMed - indexed for MEDLINE]
8.

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration.

Wils H, Kleinberger G, Janssens J, Pereson S, Joris G, Cuijt I, Smits V, Ceuterick-de Groote C, Van Broeckhoven C, Kumar-Singh S.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3858-63. doi: 10.1073/pnas.0912417107. Epub 2010 Feb 3.

PMID:
20133711
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration.

Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VM.

Acta Neuropathol. 2007 May;113(5):543-8. Epub 2007 Apr 6.

PMID:
17415574
[PubMed - indexed for MEDLINE]
10.

Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice.

Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L.

Mol Neurodegener. 2011 Oct 26;6:73. doi: 10.1186/1750-1326-6-73.

PMID:
22029574
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Frequency of ubiquitin and FUS-positive, TDP-43-negative frontotemporal lobar degeneration.

Seelaar H, Klijnsma KY, de Koning I, van der Lugt A, Chiu WZ, Azmani A, Rozemuller AJ, van Swieten JC.

J Neurol. 2010 May;257(5):747-53. doi: 10.1007/s00415-009-5404-z. Epub 2009 Nov 28.

PMID:
19946779
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H.

Ann Neurol. 2008 Jul;64(1):60-70. doi: 10.1002/ana.21425.

PMID:
18546284
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43.

Kosaka T, Fu YJ, Shiga A, Ishidaira H, Tan CF, Tani T, Koike R, Onodera O, Nishizawa M, Kakita A, Takahashi H.

Neuropathology. 2012 Aug;32(4):373-84. doi: 10.1111/j.1440-1789.2011.01271.x. Epub 2011 Nov 21.

PMID:
22098653
[PubMed - indexed for MEDLINE]
14.

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.

Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S.

J Pathol. 2012 Sep;228(1):67-76. doi: 10.1002/path.4043. Epub 2012 Jun 25.

PMID:
22733568
[PubMed - indexed for MEDLINE]
15.

Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.

Arai T, Hasegawa M, Nonoka T, Kametani F, Yamashita M, Hosokawa M, Niizato K, Tsuchiya K, Kobayashi Z, Ikeda K, Yoshida M, Onaya M, Fujishiro H, Akiyama H.

Neuropathology. 2010 Apr;30(2):170-81. doi: 10.1111/j.1440-1789.2009.01089.x. Epub 2010 Jan 19. Review.

PMID:
20102522
[PubMed - indexed for MEDLINE]
16.

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies.

Geser F, Lee VM, Trojanowski JQ.

Neuropathology. 2010 Apr;30(2):103-12. doi: 10.1111/j.1440-1789.2009.01091.x. Epub 2010 Jan 25. Review.

PMID:
20102519
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions.

Mackenzie IR, Foti D, Woulfe J, Hurwitz TA.

Brain. 2008 May;131(Pt 5):1282-93. doi: 10.1093/brain/awn061. Epub 2008 Mar 24.

PMID:
18362096
[PubMed - indexed for MEDLINE]
Free Article
18.

TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Grossman M, Wood EM, Moore P, Neumann M, Kwong L, Forman MS, Clark CM, McCluskey LF, Miller BL, Lee VM, Trojanowski JQ.

Arch Neurol. 2007 Oct;64(10):1449-54.

PMID:
17923628
[PubMed - indexed for MEDLINE]
19.

Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.

Hortobágyi T, Troakes C, Nishimura AL, Vance C, van Swieten JC, Seelaar H, King A, Al-Sarraj S, Rogelj B, Shaw CE.

Acta Neuropathol. 2011 Apr;121(4):519-27. doi: 10.1007/s00401-011-0813-3. Epub 2011 Mar 1.

PMID:
21360076
[PubMed - indexed for MEDLINE]
20.

Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy.

Thorpe JR, Tang H, Atherton J, Cairns NJ.

J Neural Transm. 2008 Dec;115(12):1661-71. doi: 10.1007/s00702-008-0137-1. Epub 2008 Oct 31.

PMID:
18974920
[PubMed - indexed for MEDLINE]
Free PMC Article

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