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Items: 1 to 20 of 124

1.

Reactivation of hepatic EPO synthesis in mice after PHD loss.

Minamishima YA, Kaelin WG Jr.

Science. 2010 Jul 23;329(5990):407. doi: 10.1126/science.1192811.

2.

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.

Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.

Mol Cell Biol. 2015 Aug;35(15):2658-72. doi: 10.1128/MCB.00161-15. Epub 2015 May 26.

3.

Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

Duan LJ, Takeda K, Fong GH.

Am J Pathol. 2014 Apr;184(4):1240-50. doi: 10.1016/j.ajpath.2013.12.014. Epub 2014 Feb 6.

4.

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B.

Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20.

5.

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.

Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH.

Blood. 2008 Mar 15;111(6):3229-35. Epub 2007 Dec 4.

6.

Integrity of the prolyl hydroxylase domain protein 2:erythropoietin pathway in aging mice.

Li X, Sutherland S, Takeda K, Fong GH, Lee FS.

Blood Cells Mol Dis. 2010 Jun 15;45(1):9-19. doi: 10.1016/j.bcmd.2010.03.003. Epub 2010 Apr 18.

7.

Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

Querbes W, Bogorad RL, Moslehi J, Wong J, Chan AY, Bulgakova E, Kuchimanchi S, Akinc A, Fitzgerald K, Koteliansky V, Kaelin WG Jr.

Blood. 2012 Aug 30;120(9):1916-22. doi: 10.1182/blood-2012-04-423715. Epub 2012 May 18.

8.
9.

Hypoxia-induced erythropoietin production: a paradigm for oxygen-regulated gene expression.

Stockmann C, Fandrey J.

Clin Exp Pharmacol Physiol. 2006 Oct;33(10):968-79. Review.

PMID:
17002676
10.

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis.

Liu Q, Davidoff O, Niss K, Haase VH.

J Clin Invest. 2012 Dec;122(12):4635-44. doi: 10.1172/JCI63924. Epub 2012 Nov 1.

11.

Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.

Laitala A, Aro E, Walkinshaw G, Mäki JM, Rossi M, Heikkilä M, Savolainen ER, Arend M, Kivirikko KI, Koivunen P, Myllyharju J.

Blood. 2012 Oct 18;120(16):3336-44. doi: 10.1182/blood-2012-07-441824. Epub 2012 Sep 5.

12.

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N.

J Am Soc Nephrol. 2016 Feb;27(2):428-38. doi: 10.1681/ASN.2014121184. Epub 2015 Jun 8.

PMID:
26054543
13.

Recent advances and clinical application of erythropoietin and erythropoiesis-stimulating agents.

Tanaka T, Nangaku M.

Exp Cell Res. 2012 May 15;318(9):1068-73. doi: 10.1016/j.yexcr.2012.02.035. Epub 2012 Mar 6.

PMID:
22414872
14.

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

Bernhardt WM, Wiesener MS, Scigalla P, Chou J, Schmieder RE, Günzler V, Eckardt KU.

J Am Soc Nephrol. 2010 Dec;21(12):2151-6. doi: 10.1681/ASN.2010010116. Epub 2010 Nov 29.

15.

Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC.

Frede S, Freitag P, Geuting L, Konietzny R, Fandrey J.

Blood. 2011 May 5;117(18):4905-14. doi: 10.1182/blood-2010-07-298083. Epub 2011 Mar 15. Retraction in: Blood. 2014 May 22;123(21):3365.

16.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R, Gollapudi A, Keohane CA, Lingham RB, Mandala SM, DeMartino JA, Tong X, Wolff M, Steinhuebel D, Kieczykowski GR, Fleitz FJ, Chapman K, Athanasopoulos J, Adam G, Akyuz CD, Jena DK, Lusen JW, Meng J, Stein BD, Xia L, Sherer EC, Hale JJ.

J Med Chem. 2012 Apr 12;55(7):2945-59. doi: 10.1021/jm201542d. Epub 2012 Feb 27.

PMID:
22364528
17.

Hypoxic regulation of erythropoiesis and iron metabolism.

Haase VH.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F1-13. doi: 10.1152/ajprenal.00174.2010. Epub 2010 May 5. Review.

18.

Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance.

Kasiganesan H, Sridharan V, Wright G.

Acta Physiol (Oxf). 2007 Jun;190(2):163-9. Epub 2007 Mar 30.

PMID:
17394573
19.

[Reciprocal regulation between hypoxia-inducible factor-1alpha and its prolyl hydroxylases in hypoxic pulmonary hypertension rats].

Chen YR, Dai AG, Hu RC.

Zhonghua Jie He He Hu Xi Za Zhi. 2006 Oct;29(10):668-73. Chinese.

PMID:
17129494
20.

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ.

Cell. 2012 Mar 30;149(1):63-74. doi: 10.1016/j.cell.2012.01.051.

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