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Items: 1 to 20 of 99

1.

E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.

Yang Y, Do H, Tian X, Zhang C, Liu X, Dada LA, Sznajder JI, Liu J.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13444-9. doi: 10.1073/pnas.0913690107. Epub 2010 Jul 12.

2.

Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation.

Liu J, Yan J, Jiang S, Wen J, Chen L, Zhao Y, Lin A.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):191-6. doi: 10.1073/pnas.1105176108. Epub 2011 Dec 19.

3.

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.

Liu J, Zhao Y, Eilers M, Lin A.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18279-84. doi: 10.1073/pnas.0906328106. Epub 2009 Oct 7.

4.

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW.

Genes Dev. 2013 May 15;27(10):1101-14. doi: 10.1101/gad.214577.113.

5.

Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, Mao R, Chang A, Xu G, Schneider MD, Zhang H, Fu S, Qin J, Yang J.

J Biol Chem. 2010 Feb 19;285(8):5347-60. doi: 10.1074/jbc.M109.076976. Epub 2009 Dec 28.

6.

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M.

Cell. 2006 Feb 10;124(3):601-13.

7.

Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death.

Lee CK, Yang Y, Chen C, Liu J.

Oncogene. 2016 Apr 14;35(15):1988-95. doi: 10.1038/onc.2015.275. Epub 2015 Jul 27.

8.

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z.

EMBO J. 2004 Jan 28;23(2):322-32. Epub 2004 Jan 8.

9.

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.

Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, Bernards R, Eilers M.

EMBO J. 2008 Nov 5;27(21):2851-61. doi: 10.1038/emboj.2008.200. Epub 2008 Oct 16.

10.
11.

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.

Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K, Wei Y.

J Biol Chem. 2013 Jan 18;288(3):1785-94. doi: 10.1074/jbc.M112.439760. Epub 2012 Dec 4.

12.

The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.

Albor A, El-Hizawi S, Horn EJ, Laederich M, Frosk P, Wrogemann K, Kulesz-Martin M.

J Biol Chem. 2006 Sep 1;281(35):25850-66. Epub 2006 Jun 30.

13.

Miz1 is required to maintain autophagic flux.

Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M.

Nat Commun. 2013;4:2535. doi: 10.1038/ncomms3535.

14.

Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein.

Scudiero I, Zotti T, Ferravante A, Vessichelli M, Reale C, Masone MC, Leonardi A, Vito P, Stilo R.

J Biol Chem. 2012 Feb 17;287(8):6053-61. doi: 10.1074/jbc.M111.300137. Epub 2012 Jan 3.

16.

GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.

Zhang B, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB.

Cell Res. 2008 Sep;18(9):900-10. doi: 10.1038/cr.2008.75.

17.

Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.

Haimerl F, Erhardt A, Sass G, Tiegs G.

J Biol Chem. 2009 Jan 2;284(1):495-504. doi: 10.1074/jbc.M803533200. Epub 2008 Nov 10.

18.

Oncrasin targets the JNK-NF-κB axis to sensitize glioma cells to TNFα-induced apoptosis.

Gupta P, Dixit D, Sen E.

Carcinogenesis. 2013 Feb;34(2):388-96. doi: 10.1093/carcin/bgs352. Epub 2012 Nov 3.

19.

AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2.

Choi JW, Kim DG, Park MC, Um JY, Han JM, Park SG, Choi EC, Kim S.

J Cell Sci. 2009 Aug 1;122(Pt 15):2710-5. doi: 10.1242/jcs.049767. Epub 2009 Jul 7.

20.

Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase.

Pantano C, Shrivastava P, McElhinney B, Janssen-Heininger Y.

J Biol Chem. 2003 Nov 7;278(45):44091-6. Epub 2003 Aug 25.

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