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Items: 1 to 20 of 98


Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.

Lee K, Gudapati P, Dragovic S, Spencer C, Joyce S, Killeen N, Magnuson MA, Boothby M.

Immunity. 2010 Jun 25;32(6):743-53. doi: 10.1016/j.immuni.2010.06.002.


Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M.

Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.


mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.


Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia.

Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M.

J Exp Med. 2012 Apr 9;209(4):713-28. doi: 10.1084/jem.20111470. Epub 2012 Apr 2.


An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.

Wang Y, Souabni A, Flavell RA, Wan YY.

J Immunol. 2010 Nov 15;185(10):5983-92. doi: 10.4049/jimmunol.1001255. Epub 2010 Oct 13.


Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.

Nawijn MC, Dingjan GM, Ferreira R, Lambrecht BN, Karis A, Grosveld F, Savelkoul H, Hendriks RW.

J Immunol. 2001 Jul 15;167(2):724-32.


The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD.

Nat Immunol. 2011 Apr;12(4):295-303. doi: 10.1038/ni.2005. Epub 2011 Feb 27.


Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.

Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D.

J Immunol. 2003 Oct 1;171(7):3542-9.


Cytokine transcriptional events during helper T cell subset differentiation.

Lederer JA, Perez VL, DesRoches L, Kim SM, Abbas AK, Lichtman AH.

J Exp Med. 1996 Aug 1;184(2):397-406.


Altered Th1 cell differentiation programming by CIITA deficiency.

Patel DR, Kaplan MH, Chang CH.

J Immunol. 2004 Nov 1;173(9):5501-8.


CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene.

Ankathatti Munegowda M, Xu S, Freywald A, Xiang J.

Mol Immunol. 2012 Jun;51(2):143-9. doi: 10.1016/j.molimm.2012.02.120. Epub 2012 Mar 17.


A novel transcription factor, T-bet, directs Th1 lineage commitment.

Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH.

Cell. 2000 Mar 17;100(6):655-69.


PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.


T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Epub 2006 Mar 6. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.


Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.

Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA.

Nat Immunol. 2007 Aug;8(8):825-34. Epub 2007 Jun 24.


T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex.

Yamashita M, Katsumata M, Iwashima M, Kimura M, Shimizu C, Kamata T, Shin T, Seki N, Suzuki S, Taniguchi M, Nakayama T.

J Exp Med. 2000 Jun 5;191(11):1869-79.


Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways.

Chen XG, Liu F, Song XF, Wang ZH, Dong ZQ, Hu ZQ, Lan RZ, Guan W, Zhou TG, Xu XM, Lei H, Ye ZQ, Peng EJ, Du LH, Zhuang QY.

Mol Carcinog. 2010 Jun;49(6):603-10. doi: 10.1002/mc.20628.


Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells.

Wei WC, Liu CP, Yang WC, Shyur LF, Sheu JH, Chen SS, Yang NS.

J Leukoc Biol. 2015 Jun;97(6):1071-80. doi: 10.1189/jlb.2A0414-206RR. Epub 2015 Apr 15.

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