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Results: 1 to 20 of 109

1.

Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.

Kockel L, Kerr KS, Melnick M, Br├╝ckner K, Hebrok M, Perrimon N.

PLoS Genet. 2010 Jun 17;6(6):e1000990. doi: 10.1371/journal.pgen.1000990.

PMID:
20585550
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.

Miron M, Lasko P, Sonenberg N.

Mol Cell Biol. 2003 Dec;23(24):9117-26.

PMID:
14645523
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo.

Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, Grifoni D, Stocker H, Tabak E, Bellosta P.

BMC Biol. 2011 Sep 27;9:65. doi: 10.1186/1741-7007-9-65.

PMID:
21951762
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.

Yang Q, Inoki K, Kim E, Guan KL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):6811-6. Epub 2006 Apr 20.

PMID:
16627617
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E.

PLoS One. 2013;8(2):e57289. doi: 10.1371/journal.pone.0057289. Epub 2013 Feb 21.

PMID:
23437362
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.

Lin CY, Hsu SC, Lee HS, Lin SH, Tsai CS, Huang SM, Shih CC, Hsu YJ.

J Vasc Surg. 2013 Feb;57(2):475-85. doi: 10.1016/j.jvs.2012.07.037. Epub 2012 Dec 21.

PMID:
23265586
[PubMed - indexed for MEDLINE]
7.

Role for the phosphatidylinositol 3-kinase-Akt-TOR pathway during sindbis virus replication in arthropods.

Patel RK, Hardy RW.

J Virol. 2012 Apr;86(7):3595-604. doi: 10.1128/JVI.06625-11. Epub 2012 Jan 18.

PMID:
22258238
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling.

Martin KA, Merenick BL, Ding M, Fetalvero KM, Rzucidlo EM, Kozul CD, Brown DJ, Chiu HY, Shyu M, Drapeau BL, Wagner RJ, Powell RJ.

J Biol Chem. 2007 Dec 7;282(49):36112-20. Epub 2007 Sep 30.

PMID:
17908691
[PubMed - indexed for MEDLINE]
Free Article
9.

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.

Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1258-70. doi: 10.1152/ajpcell.00105.2009. Epub 2009 Apr 8.

PMID:
19357233
[PubMed - indexed for MEDLINE]
Free Article
10.
11.

Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.

Ginion A, Auquier J, Benton CR, Mouton C, Vanoverschelde JL, Hue L, Horman S, Beauloye C, Bertrand L.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H469-77. doi: 10.1152/ajpheart.00986.2010. Epub 2011 May 20.

PMID:
21602475
[PubMed - indexed for MEDLINE]
Free Article
12.

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.

Ye X, Deng Y, Lai ZC.

Dev Biol. 2012 Sep 1;369(1):115-23. doi: 10.1016/j.ydbio.2012.06.014. Epub 2012 Jun 23.

PMID:
22732571
[PubMed - indexed for MEDLINE]
Free Article
13.

Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways.

Gerasimovskaya EV, Tucker DA, Weiser-Evans M, Wenzlau JM, Klemm DJ, Banks M, Stenmark KR.

J Biol Chem. 2005 Jan 21;280(3):1838-48. Epub 2004 Nov 1.

PMID:
15522879
[PubMed - indexed for MEDLINE]
Free Article
14.

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

Khamzina L, Veilleux A, Bergeron S, Marette A.

Endocrinology. 2005 Mar;146(3):1473-81. Epub 2004 Dec 16.

PMID:
15604215
[PubMed - indexed for MEDLINE]
15.

Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.

Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.

Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.

PMID:
15001544
[PubMed - indexed for MEDLINE]
16.

Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts.

Cao X, Kambe F, Moeller LC, Refetoff S, Seo H.

Mol Endocrinol. 2005 Jan;19(1):102-12. Epub 2004 Sep 23.

PMID:
15388791
[PubMed - indexed for MEDLINE]
17.

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.

Dobashi Y, Suzuki S, Kimura M, Matsubara H, Tsubochi H, Imoto I, Ooi A.

Hum Pathol. 2011 Feb;42(2):214-26. doi: 10.1016/j.humpath.2010.05.025. Epub 2010 Oct 30.

PMID:
21040950
[PubMed - indexed for MEDLINE]
18.

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.

Sanchez Canedo C, Demeulder B, Ginion A, Bayascas JR, Balligand JL, Alessi DR, Vanoverschelde JL, Beauloye C, Hue L, Bertrand L.

Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E761-9. doi: 10.1152/ajpendo.00421.2009. Epub 2010 Jan 5.

PMID:
20051528
[PubMed - indexed for MEDLINE]
Free Article
19.

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.

Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH.

Nat Cell Biol. 2007 Mar;9(3):316-23. Epub 2007 Feb 4.

PMID:
17277771
[PubMed - indexed for MEDLINE]
20.

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