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Results: 1 to 20 of 104

1.

Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice.

Smith DE, Hu Y, Shen H, Nagaraja TN, Fenstermacher JD, Keep RF.

J Cereb Blood Flow Metab. 2011 Jan;31(1):250-61. doi: 10.1038/jcbfm.2010.84. Epub 2010 Jun 23.

PMID:
20571525
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.

Shen H, Ocheltree SM, Hu Y, Keep RF, Smith DE.

Drug Metab Dispos. 2007 Jul;35(7):1209-16. Epub 2007 Apr 23.

PMID:
17452417
[PubMed - indexed for MEDLINE]
Free Article
3.

Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice.

Ocheltree SM, Shen H, Hu Y, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2005 Oct;315(1):240-7. Epub 2005 Jun 29.

PMID:
15987832
[PubMed - indexed for MEDLINE]
Free Article
4.

Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2004 Feb;308(2):462-7. Epub 2003 Nov 4.

PMID:
14600253
[PubMed - indexed for MEDLINE]
Free Article
5.

Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE.

Pharm Res. 2004 Sep;21(9):1680-5.

PMID:
15497696
[PubMed - indexed for MEDLINE]
6.

PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus.

Shen H, Keep RF, Hu Y, Smith DE.

J Pharmacol Exp Ther. 2005 Dec;315(3):1101-8. Epub 2005 Aug 17.

PMID:
16107517
[PubMed - indexed for MEDLINE]
Free Article
7.

Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine.

Teuscher NS, Novotny A, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2000 Aug;294(2):494-9.

PMID:
10900224
[PubMed - indexed for MEDLINE]
Free Article
8.

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

Shen H, Smith DE, Keep RF, Xiang J, Brosius FC 3rd.

J Biol Chem. 2003 Feb 14;278(7):4786-91. Epub 2002 Dec 6.

PMID:
12473671
[PubMed - indexed for MEDLINE]
Free Article
9.

Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture.

Shu C, Shen H, Teuscher NS, Lorenzi PJ, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2002 Jun;301(3):820-9.

PMID:
12023509
[PubMed - indexed for MEDLINE]
Free Article
10.

PEPT2-mediated uptake of neuropeptides in rat choroid plexus.

Teuscher NS, Keep RF, Smith DE.

Pharm Res. 2001 Jun;18(6):807-13.

PMID:
11474785
[PubMed - indexed for MEDLINE]
11.

Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.

Huh Y, Hynes SM, Smith DE, Feng MR.

Pharm Res. 2013 May;30(5):1423-34. doi: 10.1007/s11095-013-0980-0. Epub 2013 Feb 1.

PMID:
23371515
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice.

Teuscher NS, Shen H, Shu C, Xiang J, Keep RF, Smith DE.

J Neurochem. 2004 Apr;89(2):375-82. Erratum in: J Neurochem. 2004 Nov;91(4):1024.

PMID:
15056281
[PubMed - indexed for MEDLINE]
13.

Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice.

Ma K, Hu Y, Smith DE.

J Pharm Sci. 2011 Feb;100(2):767-74. doi: 10.1002/jps.22277. Epub 2010 Sep 22.

PMID:
20862774
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.

Kamal MA, Jiang H, Hu Y, Keep RF, Smith DE.

Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R986-91. doi: 10.1152/ajpregu.90744.2008. Epub 2009 Feb 18.

PMID:
19225147
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity.

Kamal MA, Keep RF, Smith DE.

Drug Metab Pharmacokinet. 2008;23(4):236-42. Review.

PMID:
18762710
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3.

Kuroda M, Kusuhara H, Endou H, Sugiyama Y.

J Pharmacol Exp Ther. 2005 Aug;314(2):855-61. Epub 2005 May 13.

PMID:
15894718
[PubMed - indexed for MEDLINE]
Free Article
17.

Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures.

Xiang J, Chiang PP, Hu Y, Smith DE, Keep RF.

Neurosci Lett. 2006 Apr 3;396(3):225-9. Epub 2005 Dec 20.

PMID:
16364547
[PubMed - indexed for MEDLINE]
18.

Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice.

Jiang H, Hu Y, Keep RF, Smith DE.

J Neurochem. 2009 Jun;109(5):1536-43. doi: 10.1111/j.1471-4159.2009.06090.x. Epub 2009 Apr 4.

PMID:
19383084
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mechanisms of 5-aminolevulinic acid uptake at the choroid plexus.

Novotny A, Xiang J, Stummer W, Teuscher NS, Smith DE, Keep RF.

J Neurochem. 2000 Jul;75(1):321-8.

PMID:
10854277
[PubMed - indexed for MEDLINE]
20.

Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.

Hu Y, Ocheltree SM, Xiang J, Keep RF, Smith DE.

Pharm Res. 2005 Aug;22(8):1281-6. Epub 2005 Aug 3.

PMID:
16078137
[PubMed - indexed for MEDLINE]

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