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Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis.

Pelletier JP, Raynauld JP, Caron J, Mineau F, Abram F, Dorais M, Haraoui B, Choquette D, Martel-Pelletier J.

Ann Rheum Dis. 2010 Dec;69(12):2095-101. doi: 10.1136/ard.2009.122002. Epub 2010 Jun 22.


Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.

Raynauld JP, Martel-Pelletier J, Bias P, Laufer S, Haraoui B, Choquette D, Beaulieu AD, Abram F, Dorais M, Vignon E, Pelletier JP; Canadian Licofelone Study Group.

Ann Rheum Dis. 2009 Jun;68(6):938-47. doi: 10.1136/ard.2008.088732. Epub 2008 Jul 23.


Risk factors predictive of joint replacement in a 2-year multicentre clinical trial in knee osteoarthritis using MRI: results from over 6 years of observation.

Raynauld JP, Martel-Pelletier J, Haraoui B, Choquette D, Dorais M, Wildi LM, Abram F, Pelletier JP; Canadian Licofelone Study Group.

Ann Rheum Dis. 2011 Aug;70(8):1382-8. doi: 10.1136/ard.2010.146407. Epub 2011 May 8.


Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: results from a randomised controlled clinical trial using MRI.

Wildi LM, Raynauld JP, Martel-Pelletier J, Abram F, Dorais M, Pelletier JP.

Ann Rheum Dis. 2010 Dec;69(12):2118-24. doi: 10.1136/ard.2009.127993. Epub 2010 Jul 7.


Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.

Abadie E, Ethgen D, Avouac B, Bouvenot G, Branco J, Bruyere O, Calvo G, Devogelaer JP, Dreiser RL, Herrero-Beaumont G, Kahan A, Kreutz G, Laslop A, Lemmel EM, Nuki G, Van De Putte L, Vanhaelst L, Reginster JY; Group for the Respect of Excellence and Ethics in Science.

Osteoarthritis Cartilage. 2004 Apr;12(4):263-8. Review.


An open-label pilot study evaluating by magnetic resonance imaging the potential for a disease-modifying effect of celecoxib compared to a modelized historical control cohort in the treatment of knee osteoarthritis.

Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, Choquette D, Haraoui B, Abram F, Pelletier JP.

Semin Arthritis Rheum. 2010 Dec;40(3):185-92. doi: 10.1016/j.semarthrit.2009.10.003. Epub 2010 Feb 4.


Analysis of the precision and sensitivity to change of different approaches to assess cartilage loss by quantitative MRI in a longitudinal multicentre clinical trial in patients with knee osteoarthritis.

Raynauld JP, Martel-Pelletier J, Abram F, Dorais M, Haraoui B, Choquette D, Bias P, Emmert KH, Laufer S, Pelletier JP.

Arthritis Res Ther. 2008;10(6):R129. doi: 10.1186/ar2543. Epub 2008 Nov 5.


Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study.

Pelletier JP, Raynauld JP, Berthiaume MJ, Abram F, Choquette D, Haraoui B, Beary JF, Cline GA, Meyer JM, Martel-Pelletier J.

Arthritis Res Ther. 2007;9(4):R74.


Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes.

Raynauld JP, Martel-Pelletier J, Berthiaume MJ, Labonté F, Beaudoin G, de Guise JA, Bloch DA, Choquette D, Haraoui B, Altman RD, Hochberg MC, Meyer JM, Cline GA, Pelletier JP.

Arthritis Rheum. 2004 Feb;50(2):476-87.


Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees.

Brandt KD, Mazzuca SA, Buckwalter KA.

Rheumatology (Oxford). 2006 Nov;45(11):1389-94. Epub 2006 Apr 10.


Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment.

Eckstein F, Cicuttini F, Raynauld JP, Waterton JC, Peterfy C.

Osteoarthritis Cartilage. 2006;14 Suppl A:A46-75. Epub 2006 May 19. Review.


Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI.

Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, Abram F, Dorais M, Pelletier JP.

Ann Rheum Dis. 2011 Jun;70(6):982-9. doi: 10.1136/ard.2010.140848. Epub 2011 Mar 1.


Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study.

Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT.

Arthritis Res Ther. 2007;9(5):R108.


Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study.

Bingham CO 3rd, Buckland-Wright JC, Garnero P, Cohen SB, Dougados M, Adami S, Clauw DJ, Spector TD, Pelletier JP, Raynauld JP, Strand V, Simon LS, Meyer JM, Cline GA, Beary JF.

Arthritis Rheum. 2006 Nov;54(11):3494-507.


Hylan G-F 20 efficacy on articular cartilage quality in patients with knee osteoarthritis: clinical and MRI assessment.

Cubukçu D, Ardiç F, Karabulut N, Topuz O.

Clin Rheumatol. 2005 Aug;24(4):336-41. Epub 2004 Dec 14.


Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis.

Boileau C, Martel-Pelletier J, Abram F, Raynauld JP, Troncy E, D'Anjou MA, Moreau M, Pelletier JP.

Ann Rheum Dis. 2008 Jul;67(7):926-32. Epub 2007 Oct 25.


Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure.

Berry PA, Maciewicz RA, Wluka AE, Downey-Jones MD, Forbes A, Hellawell CJ, Cicuttini FM.

Ann Rheum Dis. 2010 Oct;69(10):1816-22. doi: 10.1136/ard.2009.124420. Epub 2010 Jun 15.


Efficacy and safety of Derris scandens Benth extracts in patients with knee osteoarthritis.

Kuptniratsaikul V, Pinthong T, Bunjob M, Thanakhumtorn S, Chinswangwatanakul P, Thamlikitkul V.

J Altern Complement Med. 2011 Feb;17(2):147-53. doi: 10.1089/acm.2010.0213. Epub 2011 Feb 10.

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