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Items: 1 to 20 of 140

1.

Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.

Parachikova A, Vasilevko V, Cribbs DH, LaFerla FM, Green KN.

J Alzheimers Dis. 2010;21(2):527-42. doi: 10.3233/JAD-2010-100204.

2.

Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice.

Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG.

J Neurochem. 2013 Aug;126(4):473-82. doi: 10.1111/jnc.12305. Epub 2013 Jun 16.

3.

Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder.

Cai Z, Yan Y, Wang Y.

Clin Interv Aging. 2013;8:1089-95. doi: 10.2147/CIA.S46536. Epub 2013 Aug 19.

5.

Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice.

Dobarro M, Gerenu G, Ramírez MJ.

Int J Neuropsychopharmacol. 2013 Nov;16(10):2245-57. doi: 10.1017/S1461145713000631. Epub 2013 Jun 17.

PMID:
23768694
6.

Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice.

Joshi YB, Chu J, Praticò D.

Aging Cell. 2013 Aug;12(4):706-11. doi: 10.1111/acel.12096. Epub 2013 Jun 11.

7.

Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.

Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA.

J Neurosci. 2009 Jun 24;29(25):7957-65. doi: 10.1523/JNEUROSCI.1339-09.2009. Erratum in: J Neurosci. 2010 Jan 20;30(3):1197-8.

8.

FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation.

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.

PLoS One. 2013 Nov 4;8(11):e78033. doi: 10.1371/journal.pone.0078033. eCollection 2013.

9.

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

Noble W, Garwood C, Stephenson J, Kinsey AM, Hanger DP, Anderton BH.

FASEB J. 2009 Mar;23(3):739-50. doi: 10.1096/fj.08-113795. Epub 2008 Nov 11.

10.

Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.

McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A.

Brain Res. 2008 May 1;1207:225-36. doi: 10.1016/j.brainres.2008.01.095. Epub 2008 Feb 16.

11.

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.

Peng Y, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.

J Alzheimers Dis. 2012;29(2):379-91. doi: 10.3233/JAD-2011-111577.

PMID:
22233765
12.

Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.

Gao L, Tian S, Gao H, Xu Y.

J Mol Neurosci. 2013 Sep;51(1):138-47. doi: 10.1007/s12031-013-9966-y. Epub 2013 Jan 24.

PMID:
23345083
13.

Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice.

Rasool S, Martinez-Coria H, Milton S, Glabe CG.

Mol Neurobiol. 2013 Dec;48(3):931-40. doi: 10.1007/s12035-013-8478-7. Epub 2013 Jun 15.

PMID:
23771815
14.

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.

Durairajan SS, Liu LF, Lu JH, Chen LL, Yuan Q, Chung SK, Huang L, Li XS, Huang JD, Li M.

Neurobiol Aging. 2012 Dec;33(12):2903-19. doi: 10.1016/j.neurobiolaging.2012.02.016. Epub 2012 Mar 27.

PMID:
22459600
15.

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.

Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM.

J Neurosci. 2008 Nov 5;28(45):11500-10. doi: 10.1523/JNEUROSCI.3203-08.2008.

16.

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM.

Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9.

17.

Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model.

Orejana L, Barros-Miñones L, Aguirre N, Puerta E.

Exp Gerontol. 2013 Jun;48(6):565-71. doi: 10.1016/j.exger.2013.03.001. Epub 2013 Mar 13.

PMID:
23501261
18.

Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.

Baglietto-Vargas D, Medeiros R, Martinez-Coria H, LaFerla FM, Green KN.

Biol Psychiatry. 2013 Sep 1;74(5):357-66. doi: 10.1016/j.biopsych.2012.12.003. Epub 2013 Jan 8.

19.

Neutralization of soluble, synaptotoxic amyloid β species by antibodies is epitope specific.

Zago W, Buttini M, Comery TA, Nishioka C, Gardai SJ, Seubert P, Games D, Bard F, Schenk D, Kinney GG.

J Neurosci. 2012 Feb 22;32(8):2696-702. doi: 10.1523/JNEUROSCI.1676-11.2012.

20.

Xanthoceraside rescues learning and memory deficits through attenuating beta-amyloid deposition and tau hyperphosphorylation in APP mice.

Jin G, Wang LH, Ji XF, Chi TY, Qi Y, Jiao Q, Xu Q, Zhou XY, Zhang R, Zou LB.

Neurosci Lett. 2014 Jun 24;573:58-63. doi: 10.1016/j.neulet.2014.04.032. Epub 2014 May 5.

PMID:
24810883
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