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Results: 1 to 20 of 321

1.

Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.

Peyot ML, Pepin E, Lamontagne J, Latour MG, Zarrouki B, Lussier R, Pineda M, Jetton TL, Madiraju SR, Joly E, Prentki M.

Diabetes. 2010 Sep;59(9):2178-87. doi: 10.2337/db09-1452. Epub 2010 Jun 14.

PMID:
20547980
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.

Diabetologia. 2009 Jun;52(6):1122-32. doi: 10.1007/s00125-009-1317-8. Epub 2009 Mar 18.

PMID:
19294363
[PubMed - indexed for MEDLINE]
3.

Taurine supplementation prevents morpho-physiological alterations in high-fat diet mice pancreatic β-cells.

Ribeiro RA, Santos-Silva JC, Vettorazzi JF, Cotrim BB, Mobiolli DD, Boschero AC, Carneiro EM.

Amino Acids. 2012 Oct;43(4):1791-801. Epub 2012 Mar 15.

PMID:
22418865
[PubMed - indexed for MEDLINE]
4.

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H.

Diabetologia. 2007 Jan;50(1):74-83. Epub 2006 Nov 9.

PMID:
17093947
[PubMed - indexed for MEDLINE]
5.

Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells.

Gonzalez A, Merino B, Marroquí L, Ñeco P, Alonso-Magdalena P, Caballero-Garrido E, Vieira E, Soriano S, Gomis R, Nadal A, Quesada I.

Endocrinology. 2013 Oct;154(10):3515-24. doi: 10.1210/en.2013-1424. Epub 2013 Jul 18.

PMID:
23867214
[PubMed - indexed for MEDLINE]
6.

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.

PMID:
16868750
[PubMed - indexed for MEDLINE]
7.

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice.

Ahrén B, Simonsson E, Scheurink AJ, Mulder H, Myrsén U, Sundler F.

Metabolism. 1997 Jan;46(1):97-106.

PMID:
9005977
[PubMed - indexed for MEDLINE]
8.

Glucagon-like peptide-1 and islet lipolysis.

Sörhede Winzell M, Ahrén B.

Horm Metab Res. 2004 Nov-Dec;36(11-12):795-803.

PMID:
15655711
[PubMed - indexed for MEDLINE]
9.

Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.

Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.

J Biol Chem. 2009 Jun 19;284(25):16848-59. doi: 10.1074/jbc.M109.006650. Epub 2009 Apr 22.

PMID:
19389712
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.

Nunemaker CS, Chen M, Pei H, Kimble SD, Keller SR, Carter JD, Yang Z, Smith KM, Wu R, Bevard MH, Garmey JC, Nadler JL.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. doi: 10.1152/ajpendo.90371.2008. Epub 2008 Sep 9.

PMID:
18780776
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.

PMID:
15448158
[PubMed - indexed for MEDLINE]
Free Article
12.

Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

Diabetes. 2009 Apr;58(4):906-16. doi: 10.2337/db08-1464. Epub 2009 Jan 16.

PMID:
19151199
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.

PMID:
19903739
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Analysis of gene expression in pancreatic islets from diet-induced obese mice.

Imai Y, Patel HR, Doliba NM, Matschinsky FM, Tobias JW, Ahima RS.

Physiol Genomics. 2008 Dec 12;36(1):43-51. doi: 10.1152/physiolgenomics.00050.2008. Epub 2008 Oct 14.

PMID:
18854371
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice.

Karasawa H, Nagata-Goto S, Takaishi K, Kumagae Y.

Metabolism. 2009 Mar;58(3):296-303. doi: 10.1016/j.metabol.2008.09.028.

PMID:
19217442
[PubMed - indexed for MEDLINE]
16.

Overexpression of PPARγ specifically in pancreatic β-cells exacerbates obesity-induced glucose intolerance, reduces β-cell mass, and alters islet lipid metabolism in male mice.

Hogh KL, Craig MN, Uy CE, Nygren H, Asadi A, Speck M, Fraser JD, Rudecki AP, Baker RK, Orešič M, Gray SL.

Endocrinology. 2014 Oct;155(10):3843-52. doi: 10.1210/en.2014-1076. Epub 2014 Jul 22.

PMID:
25051434
[PubMed - indexed for MEDLINE]
17.

Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice.

He M, Su H, Gao W, Johansson SM, Liu Q, Wu X, Liao J, Young AA, Bartfai T, Wang MW.

PLoS One. 2010 Dec 3;5(12):e14205. doi: 10.1371/journal.pone.0014205.

PMID:
21151924
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

TLR4 is required for the obesity-induced pancreatic beta cell dysfunction.

Li J, Chen L, Zhang Y, Zhang WJ, Xu W, Qin Y, Xu J, Zou D.

Acta Biochim Biophys Sin (Shanghai). 2013 Dec;45(12):1030-8. doi: 10.1093/abbs/gmt092. Epub 2013 Aug 28. Erratum in: Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):167.

PMID:
23985305
[PubMed - indexed for MEDLINE]
19.

Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models.

Omar B, Pacini G, Ahrén B.

Nutrients. 2012 Sep 28;4(10):1367-81. doi: 10.3390/nu4101367.

PMID:
23201760
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet.

Wu Y, Wu T, Wu J, Zhao L, Li Q, Varghese Z, Moorhead JF, Powis SH, Chen Y, Ruan XZ.

J Endocrinol. 2013 Oct 28;219(3):195-204. doi: 10.1530/JOE-13-0160. Print 2013 Dec.

PMID:
24029730
[PubMed - indexed for MEDLINE]
Free Article
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