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Results: 1 to 20 of 100

1.

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.

Milne TA, Kim J, Wang GG, Stadler SC, Basrur V, Whitcomb SJ, Wang Z, Ruthenburg AJ, Elenitoba-Johnson KS, Roeder RG, Allis CD.

Mol Cell. 2010 Jun 25;38(6):853-63. doi: 10.1016/j.molcel.2010.05.011. Epub 2010 Jun 10.

PMID:
20541448
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.

Muntean AG, Tan J, Sitwala K, Huang Y, Bronstein J, Connelly JA, Basrur V, Elenitoba-Johnson KS, Hess JL.

Cancer Cell. 2010 Jun 15;17(6):609-21. doi: 10.1016/j.ccr.2010.04.012.

PMID:
20541477
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

Risner LE, Kuntimaddi A, Lokken AA, Achille NJ, Birch NW, Schoenfelt K, Bushweller JH, Zeleznik-Le NJ.

J Biol Chem. 2013 Oct 11;288(41):29901-10. doi: 10.1074/jbc.M113.474858. Epub 2013 Aug 29.

PMID:
23990460
[PubMed - indexed for MEDLINE]
4.

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.

Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KS, Allis CD, Roeder RG.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15751-6. doi: 10.1073/pnas.1111498108. Epub 2011 Sep 6.

PMID:
21896721
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.

Patel A, Vought VE, Swatkoski S, Viggiano S, Howard B, Dharmarajan V, Monteith KE, Kupakuwana G, Namitz KE, Shinsky SA, Cotter RJ, Cosgrove MS.

J Biol Chem. 2014 Jan 10;289(2):868-84. doi: 10.1074/jbc.M113.501064. Epub 2013 Nov 14.

PMID:
24235145
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Cierpicki T, Risner LE, Grembecka J, Lukasik SM, Popovic R, Omonkowska M, Shultis DD, Zeleznik-Le NJ, Bushweller JH.

Nat Struct Mol Biol. 2010 Jan;17(1):62-8. doi: 10.1038/nsmb.1714. Epub 2009 Dec 13.

PMID:
20010842
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.

Wu M, Shu HB.

Chin J Cancer. 2011 Apr;30(4):240-6. Review.

PMID:
21439245
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.

Milne TA, Martin ME, Brock HW, Slany RK, Hess JL.

Cancer Res. 2005 Dec 15;65(24):11367-74.

PMID:
16357144
[PubMed - indexed for MEDLINE]
Free Article
9.

On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.

Patel A, Dharmarajan V, Vought VE, Cosgrove MS.

J Biol Chem. 2009 Sep 4;284(36):24242-56. doi: 10.1074/jbc.M109.014498. Epub 2009 Jun 25.

PMID:
19556245
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells.

Largeot A, Paggetti J, Broséus J, Aucagne R, Lagrange B, Martin RZ, Berthelet J, Quéré R, Lucchi G, Ducoroy P, Bastie JN, Delva L.

Biochim Biophys Acta. 2013 Dec;1833(12):3054-63. doi: 10.1016/j.bbamcr.2013.08.013. Epub 2013 Aug 27.

PMID:
23994619
[PubMed - indexed for MEDLINE]
11.

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

Wang J, Muntean AG, Wu L, Hess JL.

J Biol Chem. 2012 Dec 21;287(52):43410-6. doi: 10.1074/jbc.M112.423855. Epub 2012 Nov 5.

PMID:
23129768
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.

Kumar AR, Hudson WA, Chen W, Nishiuchi R, Yao Q, Kersey JH.

Blood. 2004 Mar 1;103(5):1823-8. Epub 2003 Nov 13.

PMID:
14615372
[PubMed - indexed for MEDLINE]
Free Article
13.

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.

Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ.

Blood. 2011 Jun 23;117(25):6895-905. doi: 10.1182/blood-2010-12-324699. Epub 2011 Apr 25.

PMID:
21518926
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPα and GATA-1 in myeloid leukemia with MLL-AF9.

Lee JW, Kim HS, Hwang J, Kim YH, Lim GY, Sohn WJ, Yoon SR, Kim JY, Park TS, Oh SH, Park KM, Choi SU, Ryoo ZY, Lee S.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):299-305. doi: 10.1016/j.bbrc.2012.08.048. Epub 2012 Aug 17.

PMID:
22902925
[PubMed - indexed for MEDLINE]
15.

Cell context in the control of self-renewal and proliferation regulated by MLL1.

Artinger EL, Ernst P.

Cell Cycle. 2013 Sep 15;12(18):2969-72. doi: 10.4161/cc.26032. Epub 2013 Aug 12.

PMID:
23974107
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB.

Wang X, Zhu K, Li S, Liao Y, Du R, Zhang X, Shu HB, Guo AY, Li L, Wu M.

J Cell Sci. 2012 Sep 1;125(Pt 17):4058-66. doi: 10.1242/jcs.103531. Epub 2012 May 23.

PMID:
22623725
[PubMed - indexed for MEDLINE]
Free Article
17.

High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.

Karatas H, Townsend EC, Cao F, Chen Y, Bernard D, Liu L, Lei M, Dou Y, Wang S.

J Am Chem Soc. 2013 Jan 16;135(2):669-82. doi: 10.1021/ja306028q. Epub 2012 Dec 27.

PMID:
23210835
[PubMed - indexed for MEDLINE]
18.

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells.

Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A.

Nature. 2009 Mar 26;458(7237):529-33. doi: 10.1038/nature07726. Epub 2009 Feb 11.

PMID:
19212323
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance.

Huo H, Magro PG, Pietsch EC, Patel BB, Scotto KW.

Cancer Res. 2010 Nov 1;70(21):8726-35. doi: 10.1158/0008-5472.CAN-10-0755. Epub 2010 Sep 22.

PMID:
20861184
[PubMed - indexed for MEDLINE]
Free Article
20.

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

Cao F, Chen Y, Cierpicki T, Liu Y, Basrur V, Lei M, Dou Y.

PLoS One. 2010 Nov 23;5(11):e14102. doi: 10.1371/journal.pone.0014102.

PMID:
21124902
[PubMed - indexed for MEDLINE]
Free PMC Article

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