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RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.

Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11086-91. doi: 10.1073/pnas.1000003107. Epub 2010 Jun 2.


Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.

Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA.

FASEB J. 2014 Apr;28(4):1735-44. doi: 10.1096/fj.13-235648. Epub 2014 Jan 13.


5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

Wang Q, Terauchi A, Yee CH, Umemori H, Traynor JR.

Cell Signal. 2014 Sep;26(9):1846-52. doi: 10.1016/j.cellsig.2014.04.017. Epub 2014 May 2.


The role of activation of the 5-HT1A receptor and adenylate cyclase in the antidepressant-like effect of YL-0919, a dual 5-HT1A agonist and selective serotonin reuptake inhibitor.

Qin JJ, Chen HX, Zhao N, Yuan L, Zhang YZ, Yang RF, Zhang LM, Li YF.

Neurosci Lett. 2014 Oct 17;582:104-8. doi: 10.1016/j.neulet.2014.09.009. Epub 2014 Sep 8.


Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R.

Anesth Analg. 2009 Nov;109(5):1500-5. doi: 10.1213/ANE.0b013e3181ba7815.


Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart.

Waterson RE, Thompson CG, Mabe NW, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR.

Cardiovasc Res. 2011 Jul 1;91(1):45-52. doi: 10.1093/cvr/cvr054. Epub 2011 Feb 23.


5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat.

De Vry J, Schreiber R, Melon C, Dalmus M, Jentzsch KR.

Eur Neuropsychopharmacol. 2004 Dec;14(6):487-95.


Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.


Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist.

Chen HX, Jin ZL, Zhang LM, Xue R, Xu XD, Zhao N, Qiu ZK, Wang XW, Zhang YZ, Yang RF, Li YF.

PLoS One. 2013 Dec 18;8(12):e83271. doi: 10.1371/journal.pone.0083271. eCollection 2013.


Neuronal nitric oxide synthase alteration accounts for the role of 5-HT1A receptor in modulating anxiety-related behaviors.

Zhang J, Huang XY, Ye ML, Luo CX, Wu HY, Hu Y, Zhou QG, Wu DL, Zhu LJ, Zhu DY.

J Neurosci. 2010 Feb 17;30(7):2433-41. doi: 10.1523/JNEUROSCI.5880-09.2010.


Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors.

Tordera RM, Monge A, Del Río J, Lasheras B.

Eur J Pharmacol. 2002 May 3;442(1-2):63-71.


Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR.

Mol Cell Biol. 2006 Sep;26(18):6870-9.


Selective serotonin reuptake inhibitors potentiate the rapid antidepressant-like effects of serotonin4 receptor agonists in the rat.

Lucas G, Du J, Romeas T, Mnie-Filali O, Haddjeri N, Piñeyro G, Debonnel G.

PLoS One. 2010 Feb 16;5(2):e9253. doi: 10.1371/journal.pone.0009253.


Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.

Zhang H, Wang W, Jiang Z, Shang J, Zhang L.

Arzneimittelforschung. 2010;60(3):109-15. doi: 10.1055/s-0031-1296258.


Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research.

Celada P, Bortolozzi A, Artigas F.

CNS Drugs. 2013 Sep;27(9):703-16. doi: 10.1007/s40263-013-0071-0. Review.


RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury.

Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF.

Blood. 2010 Dec 23;116(26):6092-100. doi: 10.1182/blood-2010-05-283846. Epub 2010 Sep 17.


5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test.

Günther L, Rothe J, Rex A, Voigt JP, Millan MJ, Fink H, Bert B.

Neuropharmacology. 2011 Sep;61(3):433-41. doi: 10.1016/j.neuropharm.2011.03.004. Epub 2011 Mar 17.


Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test.

Kaster MP, Santos AR, Rodrigues AL.

Brain Res Bull. 2005 Sep 30;67(1-2):53-61.


Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment.

Scorza MC, Lladó-Pelfort L, Oller S, Cortés R, Puigdemont D, Portella MJ, Pérez-Egea R, Alvarez E, Celada P, Pérez V, Artigas F.

Br J Pharmacol. 2012 Nov;167(5):1021-34. doi: 10.1111/j.1476-5381.2011.01770.x.

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