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Items: 1 to 20 of 102


Hypothalamic nitric oxide in hypoglycemia detection and counterregulation: a two-edged sword.

Fioramonti X, Song Z, Vazirani RP, Beuve A, Routh VH.

Antioxid Redox Signal. 2011 Feb 1;14(3):505-17. doi: 10.1089/ars.2010.3331. Epub 2010 Aug 17. Review.


Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation.

Fioramonti X, Marsollier N, Song Z, Fakira KA, Patel RM, Brown S, Duparc T, Pica-Mendez A, Sanders NM, Knauf C, Valet P, McCrimmon RJ, Beuve A, Magnan C, Routh VH.

Diabetes. 2010 Feb;59(2):519-28. doi: 10.2337/db09-0421. Epub 2009 Nov 23.


Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia.

Fioramonti X, Deak A, Deshpande S, Carneiro L, Zhou C, Sayed N, Orban B, Berlin JR, Pénicaud L, Leloup C, Beuve A, Routh VH.

PLoS One. 2013 Jul 19;8(7):e68709. doi: 10.1371/journal.pone.0068709. Print 2013.


Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation.

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh VH, Sherwin RS.

J Clin Invest. 2006 Jun;116(6):1723-30.


Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus.

Canabal DD, Potian JG, Duran RG, McArdle JJ, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R592-600. Epub 2007 May 30.


Perifornical hypothalamic orexin and serotonin modulate the counterregulatory response to hypoglycemic and glucoprivic stimuli.

Otlivanchik O, Le Foll C, Levin BE.

Diabetes. 2015 Jan;64(1):226-35. doi: 10.2337/db14-0671. Epub 2014 Aug 11.


Modulation of β-adrenergic receptors in the ventromedial hypothalamus influences counterregulatory responses to hypoglycemia.

Szepietowska B, Zhu W, Chan O, Horblitt A, Dziura J, Sherwin RS.

Diabetes. 2011 Dec;60(12):3154-8. doi: 10.2337/db11-0432. Epub 2011 Oct 19.


Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.

Zhu W, Czyzyk D, Paranjape SA, Zhou L, Horblitt A, Szabó G, Seashore MR, Sherwin RS, Chan O.

Am J Physiol Endocrinol Metab. 2010 May;298(5):E971-7. doi: 10.1152/ajpendo.00749.2009. Epub 2010 Feb 9.


Glucose, insulin, and leptin signaling pathways modulate nitric oxide synthesis in glucose-inhibited neurons in the ventromedial hypothalamus.

Canabal DD, Song Z, Potian JG, Beuve A, McArdle JJ, Routh VH.

Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1418-28. Epub 2006 Dec 14.


Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.

Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS.

Diabetes. 1999 Mar;48(3):584-7.


Glucose sensing neurons in the ventromedial hypothalamus.

Routh VH.

Sensors (Basel). 2010;10(10):9002-25. doi: 10.3390/s101009002. Review.


EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia.

Szepietowska B, Zhu W, Czyzyk J, Eid T, Sherwin RS.

Diabetes. 2013 Apr;62(4):1282-8. doi: 10.2337/db12-0982. Epub 2012 Dec 28.


AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.

Murphy BA, Fakira KA, Song Z, Beuve A, Routh VH.

Am J Physiol Cell Physiol. 2009 Sep;297(3):C750-8. doi: 10.1152/ajpcell.00127.2009. Epub 2009 Jul 1.


Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.

Chan O, Paranjape SA, Horblitt A, Zhu W, Sherwin RS.

Diabetes. 2013 Dec;62(12):4239-46. doi: 10.2337/db13-0770. Epub 2013 Aug 12.


Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats.

Fan X, Chan O, Ding Y, Zhu W, Mastaitis J, Sherwin R.

Diabetes. 2015 Oct;64(10):3564-72. doi: 10.2337/db15-0022. Epub 2015 Jun 30.


Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.

McCrimmon RJ, Fan X, Cheng H, McNay E, Chan O, Shaw M, Ding Y, Zhu W, Sherwin RS.

Diabetes. 2006 Jun;55(6):1755-60.


Increased GABAergic output in the ventromedial hypothalamus contributes to impaired hypoglycemic counterregulation in diabetic rats.

Chan O, Paranjape S, Czyzyk D, Horblitt A, Zhu W, Ding Y, Fan X, Seashore M, Sherwin R.

Diabetes. 2011 May;60(5):1582-9. doi: 10.2337/db10-1579. Epub 2011 Mar 16.


Extracellular glucose in rat ventromedial hypothalamus during acute and recurrent hypoglycemia.

de Vries MG, Arseneau LM, Lawson ME, Beverly JL.

Diabetes. 2003 Nov;52(11):2767-73.


Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose.

de Vries MG, Lawson MA, Beverly JL.

Am J Physiol Regul Integr Comp Physiol. 2005 Oct;289(4):R977-81.

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