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Results: 1 to 20 of 100

1.

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.

Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB.

J Exp Med. 2010 Jun 7;207(6):1145-52. doi: 10.1084/jem.20091245. Epub 2010 May 31.

PMID:
20513746
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding.

Massaad MJ, Ramesh N, Le Bras S, Giliani S, Notarangelo LD, Al-Herz W, Notarangelo LD, Geha RS.

J Allergy Clin Immunol. 2011 Apr;127(4):998-1005.e1-2. doi: 10.1016/j.jaci.2011.01.015. Epub 2011 Mar 3.

PMID:
21376381
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ.

J Exp Med. 2007 Sep 3;204(9):2213-24. Epub 2007 Aug 27.

PMID:
17724125
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function.

Blundell MP, Worth A, Bouma G, Thrasher AJ.

Dis Markers. 2010;29(3-4):157-75. doi: 10.3233/DMA-2010-0735. Review.

PMID:
21178275
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.

Burns SO, Killock DJ, Moulding DA, Metelo J, Nunes J, Taylor RR, Forge A, Thrasher AJ, Ivetic A.

Blood. 2010 Jul 1;115(26):5355-65. doi: 10.1182/blood-2009-08-236174. Epub 2010 Mar 30.

PMID:
20354175
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mutations of the Wiskott-Aldrich Syndrome Protein affect protein expression and dictate the clinical phenotypes.

Ochs HD.

Immunol Res. 2009;44(1-3):84-8. doi: 10.1007/s12026-008-8084-3. Review.

PMID:
19082760
[PubMed - indexed for MEDLINE]
7.

Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes.

Zhang J, Shehabeldin A, da Cruz LA, Butler J, Somani AK, McGavin M, Kozieradzki I, dos Santos AO, Nagy A, Grinstein S, Penninger JM, Siminovitch KA.

J Exp Med. 1999 Nov 1;190(9):1329-42.

PMID:
10544204
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene.

Beel K, Cotter MM, Blatny J, Bond J, Lucas G, Green F, Vanduppen V, Leung DW, Rooney S, Smith OP, Rosen MK, Vandenberghe P.

Br J Haematol. 2009 Jan;144(1):120-6. doi: 10.1111/j.1365-2141.2008.07416.x. Epub 2008 Nov 1.

PMID:
19006568
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.

Watanabe Y, Sasahara Y, Ramesh N, Massaad MJ, Yeng Looi C, Kumaki S, Kure S, Geha RS, Tsuchiya S.

J Allergy Clin Immunol. 2013 Sep;132(3):648-655.e1. doi: 10.1016/j.jaci.2013.03.046. Epub 2013 May 16.

PMID:
23684068
[PubMed - indexed for MEDLINE]
10.

Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia.

Devriendt K, Kim AS, Mathijs G, Frints SG, Schwartz M, Van Den Oord JJ, Verhoef GE, Boogaerts MA, Fryns JP, You D, Rosen MK, Vandenberghe P.

Nat Genet. 2001 Mar;27(3):313-7.

PMID:
11242115
[PubMed - indexed for MEDLINE]
11.

Overexpression of the Wiskott-Aldrich syndrome protein N-terminal domain in transgenic mice inhibits T cell proliferative responses via TCR signaling without affecting cytoskeletal rearrangements.

Sato M, Tsuji NM, Gotoh H, Yamashita K, Hashimoto K, Tadotsu N, Yamanaka H, Sekikawa K, Hashimoto Y.

J Immunol. 2001 Oct 15;167(8):4701-9.

PMID:
11591801
[PubMed - indexed for MEDLINE]
Free Article
12.

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity.

Moulding DA, Moeendarbary E, Valon L, Record J, Charras GT, Thrasher AJ.

Blood. 2012 Nov 1;120(18):3803-11. doi: 10.1182/blood-2012-03-419663. Epub 2012 Sep 12.

PMID:
22972986
[PubMed - indexed for MEDLINE]
Free Article
13.

Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.

Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15424-9. Epub 2007 Sep 18.

PMID:
17878299
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.

Ramesh N, Antón IM, Hartwig JH, Geha RS.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14671-6.

PMID:
9405671
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells.

Rengan R, Ochs HD, Sweet LI, Keil ML, Gunning WT, Lachant NA, Boxer LA, Omann GM.

Blood. 2000 Feb 15;95(4):1283-92.

PMID:
10666201
[PubMed - indexed for MEDLINE]
Free Article
16.

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.

Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW.

Immunity. 1998 Jul;9(1):81-91.

PMID:
9697838
[PubMed - indexed for MEDLINE]
Free Article
17.

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.

Westerberg LS, de la Fuente MA, Wermeling F, Ochs HD, Karlsson MC, Snapper SB, Notarangelo LD.

Blood. 2008 Nov 15;112(10):4139-47. doi: 10.1182/blood-2008-02-140715. Epub 2008 Sep 4.

PMID:
18772454
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia.

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, Hann IM, Gale RE, Linch DC, Thrasher AJ.

Blood. 2006 Oct 1;108(7):2182-9. Epub 2006 Jun 27.

PMID:
16804117
[PubMed - indexed for MEDLINE]
Free Article
19.

Defective actin polymerization in EBV-transformed B-cell lines from patients with the Wiskott-Aldrich syndrome.

Facchetti F, Blanzuoli L, Vermi W, Notarangelo LD, Giliani S, Fiorini M, Fasth A, Stewart DM, Nelson DL.

J Pathol. 1998 May;185(1):99-107.

PMID:
9713366
[PubMed - indexed for MEDLINE]
20.

New insights into the biology of Wiskott-Aldrich syndrome (WAS).

Thrasher AJ.

Hematology Am Soc Hematol Educ Program. 2009:132-8. doi: 10.1182/asheducation-2009.1.132. Review.

PMID:
20008191
[PubMed - indexed for MEDLINE]
Free Article

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