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Results: 1 to 20 of 60

1.

Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation.

Hamilton DL, Philp A, MacKenzie MG, Baar K.

BMC Cell Biol. 2010 May 27;11:37. doi: 10.1186/1471-2121-11-37.

PMID:
20507574
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.

Zhang J, Gao Z, Yin J, Quon MJ, Ye J.

J Biol Chem. 2008 Dec 19;283(51):35375-82. doi: 10.1074/jbc.M806480200. Epub 2008 Oct 24.

PMID:
18952604
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).

Ge Y, Yoon MS, Chen J.

J Biol Chem. 2011 Oct 14;286(41):35675-82. doi: 10.1074/jbc.M111.262881. Epub 2011 Aug 18.

PMID:
21852229
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.

Park IH, Erbay E, Nuzzi P, Chen J.

Exp Cell Res. 2005 Sep 10;309(1):211-9.

PMID:
15963500
[PubMed - indexed for MEDLINE]
5.

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells.

Tremblay F, Marette A.

J Biol Chem. 2001 Oct 12;276(41):38052-60. Epub 2001 Aug 9.

PMID:
11498541
[PubMed - indexed for MEDLINE]
Free Article
6.

Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.

Richards RG, Walker MP, Sebastian J, DiAugustine RP.

J Biol Chem. 1998 May 8;273(19):11962-9.

PMID:
9565625
[PubMed - indexed for MEDLINE]
Free Article
7.
8.

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.

Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E.

J Biol Chem. 2003 May 2;278(18):15641-51. Epub 2003 Feb 18.

PMID:
12594228
[PubMed - indexed for MEDLINE]
Free Article
9.

Insulin signaling in vascular endothelial cells: a key role for heterotrimeric G proteins revealed by siRNA-mediated Gbeta1 knockdown.

Chen H, Michel T.

Biochemistry. 2006 Jul 4;45(26):8023-33.

PMID:
16800627
[PubMed - indexed for MEDLINE]
10.

Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts.

Conejo R, Lorenzo M.

J Cell Physiol. 2001 Apr;187(1):96-108.

PMID:
11241354
[PubMed - indexed for MEDLINE]
11.

Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity.

Matsushima R, Harada N, Webster NJ, Tsutsumi YM, Nakaya Y.

J Biol Chem. 2006 Oct 6;281(40):29719-29. Epub 2006 Aug 3.

PMID:
16887816
[PubMed - indexed for MEDLINE]
Free Article
12.

Extracellular matrix induced by TGFbeta impairs insulin signal transduction in 3T3-L1 preadipose cells.

Gagnon AM, Chabot J, Pardasani D, Sorisky A.

J Cell Physiol. 1998 Jun;175(3):370-8.

PMID:
9572482
[PubMed - indexed for MEDLINE]
13.

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes.

Hers I, Tavaré JM.

Biochem J. 2005 Jun 1;388(Pt 2):713-20.

PMID:
15713122
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.

Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H.

J Biol Chem. 2003 Oct 10;278(41):39311-22. Epub 2003 Jun 3.

PMID:
12783867
[PubMed - indexed for MEDLINE]
Free Article
15.

Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.

Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E170-6.

PMID:
11739098
[PubMed - indexed for MEDLINE]
Free Article
16.

A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.

Schuppin GT, Pons S, Hügl S, Aiello LP, King GL, White M, Rhodes CJ.

Diabetes. 1998 Jul;47(7):1074-85.

PMID:
9648831
[PubMed - indexed for MEDLINE]
Free Article
17.

Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors.

Daulhac L, Kowalski-Chauvel A, Pradayrol L, Vaysse N, Seva C.

J Biol Chem. 1999 Jul 16;274(29):20657-63.

PMID:
10400698
[PubMed - indexed for MEDLINE]
Free Article
18.

Insulin signaling after exercise in insulin receptor substrate-2-deficient mice.

Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, Goodyear LJ.

Diabetes. 2002 Feb;51(2):479-83.

PMID:
11812758
[PubMed - indexed for MEDLINE]
Free Article
19.
20.

Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation.

Marino JS, Hinds TD Jr, Potter RA, Ondrus E, Onion JL, Dowling A, McLoughlin TJ, Sanchez ER, Hill JW.

BMC Cell Biol. 2013 Sep 21;14:39. doi: 10.1186/1471-2121-14-39.

PMID:
24053798
[PubMed - indexed for MEDLINE]
Free PMC Article

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