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Results: 1 to 20 of 104

1.

Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.

Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ.

Mol Biol Cell. 2010 Jul 1;21(13):2102-16. doi: 10.1091/mbc.E10-02-0098. Epub 2010 May 12.

PMID:
20462952
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.

Summers DW, Wolfe KJ, Ren HY, Cyr DM.

PLoS One. 2013;8(1):e52099. doi: 10.1371/journal.pone.0052099. Epub 2013 Jan 16.

PMID:
23341891
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.

Theodoraki MA, Nillegoda NB, Saini J, Caplan AJ.

J Biol Chem. 2012 Jul 6;287(28):23911-22. doi: 10.1074/jbc.M112.341164. Epub 2012 May 16.

PMID:
22593585
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.

PMID:
23988329
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins.

Gowda NK, Kandasamy G, Froehlich MS, Dohmen RJ, Andréasson C.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5975-80. doi: 10.1073/pnas.1216778110. Epub 2013 Mar 25.

PMID:
23530227
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

Eisele F, Wolf DH.

FEBS Lett. 2008 Dec 24;582(30):4143-6. doi: 10.1016/j.febslet.2008.11.015. Epub 2008 Nov 27.

PMID:
19041308
[PubMed - indexed for MEDLINE]
Free Article
7.

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase.

Wang L, Mao X, Ju D, Xie Y.

J Biol Chem. 2004 Dec 31;279(53):55218-23. Epub 2004 Oct 25.

PMID:
15504724
[PubMed - indexed for MEDLINE]
Free Article
8.

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.

PMID:
23653356
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

A nucleus-based quality control mechanism for cytosolic proteins.

Prasad R, Kawaguchi S, Ng DT.

Mol Biol Cell. 2010 Jul 1;21(13):2117-27. doi: 10.1091/mbc.E10-02-0111. Epub 2010 May 12.

PMID:
20462951
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The ubiquitin ligase E6-AP is induced and recruited to aggresomes in response to proteasome inhibition and may be involved in the ubiquitination of Hsp70-bound misfolded proteins.

Mishra A, Godavarthi SK, Maheshwari M, Goswami A, Jana NR.

J Biol Chem. 2009 Apr 17;284(16):10537-45. doi: 10.1074/jbc.M806804200. Epub 2009 Feb 20.

PMID:
19233847
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1.

Heck JW, Cheung SK, Hampton RY.

Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1106-11. doi: 10.1073/pnas.0910591107. Epub 2009 Dec 28.

PMID:
20080635
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT.

Mol Cell Biol. 2005 Aug;25(16):7120-36.

PMID:
16055722
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Hul5 ubiquitin ligase: good riddance to bad proteins.

Fang NN, Mayor T.

Prion. 2012 Jul 1;6(3):240-4. doi: 10.4161/pri.19929. Epub 2012 Jul 1. Review.

PMID:
22561164
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae.

Pal B, Chan NC, Helfenbaum L, Tan K, Tansey WP, Gething MJ.

Mol Biol Cell. 2007 Feb;18(2):426-40. Epub 2006 Nov 15.

PMID:
17108329
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins.

Fang NN, Ng AH, Measday V, Mayor T.

Nat Cell Biol. 2011 Oct 9;13(11):1344-52. doi: 10.1038/ncb2343.

PMID:
21983566
[PubMed - indexed for MEDLINE]
16.

Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1.

Han S, Liu Y, Chang A.

J Biol Chem. 2007 Sep 7;282(36):26140-9. Epub 2007 Jul 13.

PMID:
17631501
[PubMed - indexed for MEDLINE]
Free Article
17.
18.

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Huyer G, Piluek WF, Fansler Z, Kreft SG, Hochstrasser M, Brodsky JL, Michaelis S.

J Biol Chem. 2004 Sep 10;279(37):38369-78. Epub 2004 Jul 12.

PMID:
15252059
[PubMed - indexed for MEDLINE]
Free Article
19.

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC, Shang F.

FASEB J. 2006 Apr;20(6):741-3. Epub 2006 Feb 9.

PMID:
16469848
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.

Gauss R, Jarosch E, Sommer T, Hirsch C.

Nat Cell Biol. 2006 Aug;8(8):849-54. Epub 2006 Jul 16.

PMID:
16845381
[PubMed - indexed for MEDLINE]

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