Similar articles for PMID: 20446724

Year	Number of Results
2001	2
2002	1
2003	3
2004	4
2005	6
2006	5
2007	12
2008	15
2009	24
2010	39
2011	30
2012	23
2013	25
2014	17
2015	2
2016	1
2017	5
2018	3
2019	5
2020	6
2021	16
2022	22
2023	15
2024	0

1

Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.

Lu W, Liu CC, Thottassery JV, Bu G, Li Y. Lu W, et al. Biochemistry. 2010 Jun 8;49(22):4635-43. doi: 10.1021/bi1001486. Biochemistry. 2010. PMID: 20446724 Free PMC article.

2

The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.

Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y. Lin C, et al. PLoS One. 2013;8(2):e58102. doi: 10.1371/journal.pone.0058102. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23469146 Free PMC article.

3

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.

Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G. Li Y, et al. J Cell Sci. 2005 Nov 15;118(Pt 22):5305-14. doi: 10.1242/jcs.02651. Epub 2005 Nov 1. J Cell Sci. 2005. PMID: 16263759

4

Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.

Lin C, Lu W, Zhai L, Bethea T, Berry K, Qu Z, Waud WR, Li Y. Lin C, et al. FEBS Lett. 2011 Oct 3;585(19):3120-5. doi: 10.1016/j.febslet.2011.08.046. Epub 2011 Sep 5. FEBS Lett. 2011. PMID: 21907199 Free PMC article.

5

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN. Bourhis E, et al. J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21. J Biol Chem. 2010. PMID: 20093360 Free PMC article.

6

A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV. Murrills RJ, et al. J Cell Biochem. 2009 Dec 1;108(5):1066-75. doi: 10.1002/jcb.22335. J Cell Biochem. 2009. PMID: 19746449

7

Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.

Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S. Alapati D, et al. Pediatr Res. 2013 Jun;73(6):719-25. doi: 10.1038/pr.2013.42. Epub 2013 Mar 12. Pediatr Res. 2013. PMID: 23481549

8

Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.

Li Y, Lu W, He X, Bu G. Li Y, et al. FEBS Lett. 2006 Oct 2;580(22):5423-8. doi: 10.1016/j.febslet.2006.09.011. Epub 2006 Sep 18. FEBS Lett. 2006. PMID: 16989816 Free article.

9

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F. Ettenberg SA, et al. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15473-8. doi: 10.1073/pnas.1007428107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713706 Free PMC article.

10

Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.

Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R. Ellies DL, et al. J Bone Miner Res. 2006 Nov;21(11):1738-49. doi: 10.1359/jbmr.060810. J Bone Miner Res. 2006. PMID: 17002572 Free article.

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