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Results: 1 to 20 of 121

1.

Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Chen Z, Medina F, Liu MY, Thomas C, Sprang SR, Sternweis PC.

J Biol Chem. 2010 Jul 2;285(27):21070-81. doi: 10.1074/jbc.M110.122549. Epub 2010 Apr 29.

PMID:
20430886
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

Gasmi-Seabrook GM, Marshall CB, Cheung M, Kim B, Wang F, Jang YJ, Mak TW, Stambolic V, Ikura M.

J Biol Chem. 2010 Feb 19;285(8):5137-45. doi: 10.1074/jbc.M109.064691. Epub 2009 Dec 17.

PMID:
20018869
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

Kristelly R, Gao G, Tesmer JJ.

J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.

PMID:
15331592
[PubMed - indexed for MEDLINE]
Free Article
4.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

PMID:
21454492
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.

Oleksy A, Opaliński Ł, Derewenda U, Derewenda ZS, Otlewski J.

J Biol Chem. 2006 Oct 27;281(43):32891-7. Epub 2006 Sep 5.

PMID:
16954208
[PubMed - indexed for MEDLINE]
Free Article
6.

Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

Oleksy A, Barton H, Devedjiev Y, Purdy M, Derewenda U, Otlewski J, Derewenda ZS.

Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):740-2. Epub 2004 Mar 23.

PMID:
15039571
[PubMed - indexed for MEDLINE]
7.

Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.

Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC.

J Biol Chem. 2012 Jul 20;287(30):25490-500. doi: 10.1074/jbc.M111.333716. Epub 2012 Jun 1.

PMID:
22661716
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor.

Wells CD, Gutowski S, Bollag G, Sternweis PC.

J Biol Chem. 2001 Aug 3;276(31):28897-905. Epub 2001 May 30.

PMID:
11384980
[PubMed - indexed for MEDLINE]
Free Article
9.

X-ray crystal structures reveal two activated states for RhoC.

Dias SM, Cerione RA.

Biochemistry. 2007 Jun 5;46(22):6547-58. Epub 2007 May 12.

PMID:
17497936
[PubMed - indexed for MEDLINE]
10.

Regulation of RGS-RhoGEFs by Galpha12 and Galpha13 proteins.

Tanabe S, Kreutz B, Suzuki N, Kozasa T.

Methods Enzymol. 2004;390:285-94.

PMID:
15488184
[PubMed - indexed for MEDLINE]
11.

Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).

Yamada T, Ohoka Y, Kogo M, Inagaki S.

J Biol Chem. 2005 May 13;280(19):19358-63. Epub 2005 Mar 8.

PMID:
15755723
[PubMed - indexed for MEDLINE]
Free Article
12.

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.

Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP.

Mol Cell Biol. 2002 Oct;22(19):6895-905.

PMID:
12215546
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member.

Rümenapp U, Blomquist A, Schwörer G, Schablowski H, Psoma A, Jakobs KH.

FEBS Lett. 1999 Oct 15;459(3):313-8. Erratum in: FEBS Lett 2000 Feb 4;467(1):134-5.

PMID:
10526156
[PubMed - indexed for MEDLINE]
Free Article
14.

Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation.

Fuentes EJ, Karnoub AE, Booden MA, Der CJ, Campbell SL.

J Biol Chem. 2003 Jun 6;278(23):21188-96. Epub 2003 Mar 13.

PMID:
12637530
[PubMed - indexed for MEDLINE]
Free Article
15.

Larger than Dbl: new structural insights into RhoA activation.

Rossman KL, Sondek J.

Trends Biochem Sci. 2005 Apr;30(4):163-5. Review.

PMID:
15817389
[PubMed - indexed for MEDLINE]
16.

Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS.

J Biol Chem. 2011 Oct 7;286(40):35163-75. doi: 10.1074/jbc.M111.270918. Epub 2011 Aug 4.

PMID:
21816819
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.

Cell Signal. 2009 Nov;21(11):1569-78. doi: 10.1016/j.cellsig.2009.06.003. Epub 2009 Jun 26.

PMID:
19560536
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV.

J Biol Chem. 2013 Nov 22;288(47):34030-40. doi: 10.1074/jbc.M113.514596. Epub 2013 Oct 8.

PMID:
24106280
[PubMed - indexed for MEDLINE]
19.

Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.

Kostenko EV, Olabisi OO, Sahay S, Rodriguez PL, Whitehead IP.

Mol Cell Biol. 2006 Dec;26(23):8964-75. Epub 2006 Sep 25.

PMID:
17000758
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.

Medina F, Carter AM, Dada O, Gutowski S, Hadas J, Chen Z, Sternweis PC.

J Biol Chem. 2013 Apr 19;288(16):11325-33. doi: 10.1074/jbc.M113.450056. Epub 2013 Mar 14.

PMID:
23493395
[PubMed - indexed for MEDLINE]
Free PMC Article

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